Assessment and management of anterior vaginal wall defects presents a unique surgical challenge and is the most common site of initial prolapse in women and the most common site of recurrence.
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Anterior Compartment Prolapse: Biological Grafts
1. Miss Michelle Fynes MB BAO BCH (Hons) MRCOG DU DipUs MD (Research)
Consultant Subspecialist Urogynaecologist
Department of Reconstructive Pelvic Surgery
& Urogynaecology
St George’s Hospital and
Honorary Senior Lecturer St. Georges University of London
Presented to: RCOG Urogynaecology Surgical Masterclass 2012
Anterior Compartment Prolapse:
Biological Grafts
2. Introduction
Assessment and management of anterior
vaginal wall defects presents a unique
surgical challenge
It is the most common site of initial
prolapse in women and the most common
site of recurrence
3. Background
POP surgery undertaken in 11% of women
Surgical POP rates will increase with aging
population
Anterior vaginal wall is both the most common
site of POP (81% of surgical repairs)
Cystocele repair fails most frequently (up to
41%) Olsen AL. Obstet Gynecol. 1997;89:501–506.
Jelovsek JE. Lancet. 2007;369:1027–1038.
He. USA 2005 special studies 65+ www.census.gov.
Benson JT. Am J Obstet Gynecol. 1996;175:1418–1421.
Nguyen JN. Obstet Gynecol. 2008;111:891–898.
Nguyen JK. Obstet Gynecol Surv. 2001;56:239–246.
Maher C. IUJ 2006;17:195–201.
4. Cystocele
Analysis of “Well women” population
For women who entered the WHI protocol
without cystocele. At some point during the
study the following type of POP was diagnosed:
1 in 4 Cystocele
1 in 6 Rectocele
1 in 100 Uterine prolapse
Hendrix SL, Clark A, Nygaard I, et al.
POP in the Women's Health Initiative: gravity and gravidity.
Am J Obstet Gynecol. 2002;186:1160–1166.
5. What’s wrong with anterior
vaginal wall support?
Is the anterior compartment not as well supported by
the levator plate countering the effects of gravity &
abdominal pressure as for the posterior
compartment?
Are the attachments of the anterior compartment to
the pelvic sidewall or to the apex weaker?
Is the anterior wall more elastic or less dense when
compared with the posterior wall?
Is the anterior wall more susceptible to damage during
childbirth or weakening with aging or loss of
oestrogen?
6. George White
(1866-1926)
On reviewing the failure of
anterior repair:
The reason for failure seems to be that the normal
support of the bladder has not been sought for and
restored, but instead an irrational removal of part
of the anterior vaginal wall has been resorted to,
which could only result in disappointment and
failure.
7. Objectives
The anatomy of anterior vaginal wall support
Patho-anatomy of Cystocele
Classification and types of Cystocele
Institute appropriate surgical repair techniques
Identify those with high risk of failure based on patho-
anatomy
For successful surgical
intervention in women with
Cystocele we need to
understand:
9. Anatomy Anterior Compartment
Support
Anterior vaginal wall resembles a
trapezoidal plane because of the ventral
and more medial attachments near the
pubic symphysis and dorsal and more
lateral attachments near the ischial spine
The trapezoidal anterior wall is suspended
both sides to the parietal fascia overlying
the levator ani muscles at the arcus
tendineus fascia pelvis (ATFP)
10. Cystocele: Midline Defect
Damage to pubocervical fascia
Fascia stretches and weakens
Bladder sinks into the middle of the upper
vaginal wall
11. Cystocele: Lateral Defect
Detachment of fascia from arcus tendineus
Fascia tears away from their attachments to
the sidewalls of the pelvis
12. Clinical Presentation
FIGURE A. A transverse defect
with loss of the anterior fornix.
FIGURE B. A cephalad defect
with loss of apical attachment
at the level of the ischial spine.
13.
14. Surgical Intervention -
Midline Defect
Disappointing results with
“standard” vaginal repair
Recurrence rates vary with
definition of failure: Weber et al
2001 (56%) & Sand et al
2001(43%)
Mesh kits: commercial success
but significant concerns
regarding mesh erosion,
dyspareunia and other adverse
events
Anterior Vaginal Wall Fascial Plication
21. Biological Grafts and Cystocele Repair
Advantages
Avoid erosion
Minimise wound healing
issues
Improved sexual function
Disadvantages
Cost
Anchoring technique
Longevity of graft
Host versus graft
interaction
Outcome data
22. Clinical History
53 yrs Para 3
Referred with recurrent
cystocele in 2009
Symptoms
Vaginal bulge &
discomfort worse at
the end of the day
Urgency & occasional
UI but no SUI
No voiding difficulties
Past surgery
Vaginal Hysterectomy &
Pelvic Floor Repair
(1980)
Posterior repair &
sacrospinous fixation
(2006)
Examination
Grade 2 cystocele,
Grade 1-2 vault prolapse,
Grade 1 low rectocele
High perineum
23. Operative Procedures
Anterior colporrhaphy incorporating Arcus to Arcus
attachment with Xenoform
Sacro-spinous ligament pudendal nerve block
Low rectocele repair with revision of perineum
24.
25. Arcus Anchored Acellular Dermal Graft Compared to Anterior
Colporrhaphy for Stage II Cystoceles and Beyond
Aim: Compare acellular dermal matrix to standard colporrhaphy for repair cystoceles.
Methods: 102 patients with > Stage II anterior prolapse (Aa or Ba 0) underwent anterior
colporrhaphy with acellular dermal implant attached to arcus, between 10/2003 and
02/2007 were compared to 89 controls who received standard anterior colporrhaphy.
Objective recurrence was defined as > Stage II (Aa or Ba -1).
Results: The dermal graft and colporrhaphy groups were comparable in age, parity, BMI
and concomitant surgeries except hysteropexy and hysterectomy. Regression was
performed for possible confounders. Postoperatively, 14 (19%) recurrences were identified
in the dermal graft group vs. 26 (43%) in the colporrhaphy group (p=0.004). Two patients
underwent reoperations for cystocele recurrence in the study group versus four in the
control group. Time to normal voiding, subjective stress urinary incontinence, EBL and
length of hospital stay did not differ between groups.
Conclusion: Dermal acellular matrix provides benefit over standard colporrhaphy.
S Botros, P Sand, J Beaumont, Y Abramov, JJ Miller, RP Goldberg
IJPFD 2009
27. Table 2: Postoperative Outcomes
Arcus Graft
(n=72)
Controls
(n=61) p-value
N (%) N (%)
Anterior recurrence (Aa or Ba to -1) 14(19%) 26 (43%) 0.004
Anterior recurrence (Aa or Ba to 0) 7 (10%) 14 (23%) 0.04
Anterior recurrence (Aa or Ba past 0) 3 (4%) 2 (3%) 1.0
Posterior recurrence (Ap or Bp to -1) 9 (13%) 4 (7%) 0.25
Posterior recurrence (Ap or Bp to 0) 4 (6%) 3 (5%) 1.0
Apical recurrence (c or d to -1) 6 (8%) 6 (10%) 0.69
Postoperative UUI1 26 (41%) 11 (22%) 0.04
Postoperative SUI1 14 (22%) 5 (10%) 0.10
Postoperative dyspareunia1 (n=21 missing) 7 (14%) 8 (19%) 0.49
Mean (SD) Mean (SD)
Estimated Blood loss (mls) (n=11 missing) 246 (161) 288 (182) 0.10
Median (range) Median (range)
Length of Hospital stay (days) (n = 3 missing) 1 (0– 11) 1 (1 – 4) 0.24
1n=64 arcus graft and 50 controls with subjective follow-up
S Botros, P Sand, J Beaumont, Y Abramov, JJ Miller, RP Goldberg
IJPFD 2009
28. Efficacy and safety of using mesh or grafts in surgery for anterior and/or
posterior vaginal wall prolapse: systematic review and meta-analysis.
Jia X, Glazener C, Mowatt G, MacLennan G, Bain C, Fraser C, Burr J.
Health Services Research Unit, University of Aberdeen
OBJECTIVES: To systematically review the efficacy and safety of mesh/graft for anterior or posterior
vaginal wall prolapse surgery.
SELECTION CRITERIA: Randomised controlled trials (RCTs), nonrandomised comparative studies,
registries, case series involving at least 50 women, and RCTs published as conference abstracts from 2005
onwards.
ANALYSIS: 3 groups: anterior, posterior, anterior +/- posterior repair (not reported separately).
RESULTS: 49 studies (N=4569) mesh/graft POP repair. Median follow up 13 months (R 1-51) For Anterior
repair, short-term evidence that mesh/graft (any type) significantly reduced objective prolapse recurrence
rates compared with no mesh/graft (relative risk 0.48, 95% CI 0.32-0.72).
BJOG 2008
GRAFTS PROLAPSE
RECURRENCE
EROSION RATE
Non-absorbable synthetic
(8.8%, 48/548)
Non-absorbable
(10.2%, 68/666)
Absorbable synthetic
(23.1%, 63/273)
Absorbable synthetic
(0.7%, 1/147)
Biological graft
(17.9%, 186/1041)
Biological graft
(6.0%, 35/581).
CONCLUSIONS:
Evidence for most outcomes was too
sparse to provide meaningful
conclusions.
Rigorous long-term RCTs are required
to determine the comparative efficacy
of using mesh/graft.
29. Conclusions
Arcus to Arcus and SSF with Acellular
Cadaveric Graft repair for ≥Stage 2
Cystocele versus standard ultra-lateral
anterior vaginal repair is associated with a
56% reduction in cystocele recurrences and
46% reduction in recurrence to hymenal ring
at a mean follow-up of 15 months
Lack of specific complications and objective
reduction in prolapse requires further
evaluation
30. Role of fascial plication with
augmentation using biological graft?