thrombocytopenia briefly explained

1. Department of internal medicine
Dr. KAWTHAR AHMED ALI AHMED KADHEM
1

2. 2
DEFINETION :
THROMBOCYTOPENIA DEFINE AS A PLATELET COUNT
BELOW THE LOWER LIMIT OF NORMAL > 150,000/microL
AND THUS COULD ASSOCIATED WITH A VARAIETY OF
CONDITIONS AND RISK THAT MAY RANGE FROM LIFE-
THREATENING BLEEDING OR THROMBOSIS (eg,HIT ) TO
NO RISK AT ALL .
FACTS :
DEGREES OF THROMBOCYTOPENIA CAN BE
FURTHER SUBDIVIDED INTO :
#MILD (PLATELET COUNT 100,000-150,000/ microL
#MODERATE (50,000 TO 99,000/microL
# SEVER (LESS THAN 50,000/microL)
These numbers
must be interpreted
in the context of
underlying disease .
Keep in your mind
Dr. KAWTHAR AHMED ALI AHMED KADHEM

3. Causes of
thrombocytopenia
1) Decreased
production of
platelet
3) Increased
destruction of
platelet
2)Sequestration
4)Heamodialusion
3Dr. KAWTHAR AHMED ALI AHMED KADHEM

4. 4
Decreased
production
factors
2)Nutritional factors
-B 12 deficiency
-Folate
3)Congenital
-fanconi
1)Bone marrow damage
-aplastic anemia
- Chemotherapy / radiation exposure
- Drug induced
- Malignancy
Dr. KAWTHAR AHMED ALI AHMED KADHEM

5. Sequestration
- Splenomegaly
- Liver disease
- Malignancy
- Myelofibrosis
5
Usually associated
with SCD
Dr. KAWTHAR AHMED ALI AHMED KADHEM

6. Increased
destruction
factors
Immune related thrombocytopenia :
-ITP
-VIRAL INFECTION
- SYSTEMIC
- ALLOIMMUNE
- HIT
- DRUG INDUCED
Non- immune :
-DIC
-TTP
-HUS
-PRE-ECLAMPSIA
-HELLP
-APS
6
Dr. KAWTHAR AHMED ALI AHMED KADHEM

7. 7
Consideration
#To rule out pseudothromocytopenia #
*Preform pripheral blood smear.
Platelets clumping
Use sodium citrate tube instead of EDTA
Dr. KAWTHAR AHMED ALI AHMED KADHEM

8. 8Dr. KAWTHAR AHMED ALI AHMED KADHEM

9. SCHIZOCYTE BLASTS MICROSPHEROCYTE
9Dr. KAWTHAR AHMED ALI AHMED KADHEM

10. Dr. KAWTHAR AHMED ALI AHMED KADHEM

11. DEPENDEN
T
Dr. KAWTHAR AHMED ALI AHMED KADHEM