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Presentation given by Dale Natoli at the 2020 Virtual Pharma Expo on May 20, 2020.
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Natoli Engineering Presentation at 2020 Virtual Pharma Expo
1.
© Natoli EngineeringCompany2020. NATOLI
ENGINEERING Leading the Tablet Compression Industry for Almost a Half Century
2.
© Natoli EngineeringCompany2020. Our
Full Spectrum of Products & Services: • Tablet Compression Tooling • Tablet Presses • Tablet Press Replacement Parts and Turrets • Tablet Press Refurbishing • Tablet Compression and Encapsulation Accessories Catalog • Encapsulation Replacement Parts • Scientific Services • Natoli AIM™ Analytical Software for Tablet Compression, Encapsulation, Roller Compaction, and Blending • Hands-on Technical Training • E-Training Software • Process Troubleshooting • Natoli Advantage Support Services
3.
© Natoli EngineeringCompany2020. Technical
Training & Press Manufacturing Facility Steel Preparation Facility World Headquarters & Tool ManufacturingFacility NATOLI ENGINEERING CAMPUS St. Charles, Missouri USA Process R&D and Production Facility Turret & Replacement Part Manufacturing Facility
4.
REGIONAL TECHNICAL CENTERS ©
Natoli EngineeringCompany2020. New York California Poland
5.
© Natoli EngineeringCompany2020. Tablet
Compression Tooling • Multi-tip • Lined Dies • Expedited Services • Die Segments • Punch Coatings
6.
Automation Provides Consistent Quality
and Process Efficiency © Natoli EngineeringCompany2020.
7.
Tablet Press Line: R&D
to Medium Production © Natoli EngineeringCompany2020. NP-500 NP-400 NP-255 NP-155 NP-RD30 NP-RD10A NP-P20A
8.
© Natoli EngineeringCompany2020. Tablet
Press Replacement Parts and Turrets
9.
© Natoli EngineeringCompany2020. Encapsulation
Replacement Parts and Change Kits
10.
Technical Support © Natoli
EngineeringCompany2020. • Tablet and Tooling Design • Proper Steel Selection • Steel and Coating Selection • Consultation on Tooling Options • Metallurgical Full-Service Lab • Tool Failure Analysis NatoliMetallurgy
11.
© Natoli EngineeringCompany2020. Tablet
Compression and Encapsulation Accessories Catalog
12.
© Natoli EngineeringCompany2020. Natoli
Scientific & Natoli Institute • FormulationDevelopment • AnalyticalServices • Data AcquisitionSystems • Tablet Press & CalibrationServices • TechnicalTraining • ToolingRecommendations • Small Batch Production/ManufacturingSupport
13.
Natoli AIM™ Analytical
Software for compression, blending, encapsulation, & roller compactors © Natoli EngineeringCompany2020. • Obtainsdatadirectly from the R&D tablet press • Features intuitive,highly flexible user interface • Acquires and analyzes data,quickly displaysresults • Displaysforce and pressure in real-time • Stores data in SQL-driven databasefor easy retrieval • Generates and exports easy-to-read reports
14.
Technical Training Since
1984 © Natoli EngineeringCompany2020. • Hands-on and classroom training • Custom on-site trainings
15.
© Natoli EngineeringCompany2020. Natoli
Advantage Setting a Global Standard for Efficiency • Standardized Training • SOP Creation/Refinement • Maintenance Procedures • Tablet Design & Tooling Support • Inventory Management • Equipment Assessment & Services
16.
© Natoli EngineeringCompany2020. Tooling
Tech Tip For the first time measure what matters, punch tip wear! Punch tip diameters are engineered using a tight tolerance and critical for tablet quality and press operation. Tool maintenance manuals and most SOPs refer to a measuring instrument called a micrometer to inspect and manage this critical dimension…
17.
© Natoli EngineeringCompany2020. Actual
punch tip wear not measured by a micrometer • It measure the largest diameter between the anvils • Can not measure wear below the tip plane However, although the micrometer is acceptable for checking new punches, it can not measure actual punch tip wear responsible for poor tablet quality. And Tip Wear is often related to……
18.
Tablet Deficiencies such
as… © Natoli EngineeringCompany2020. CAPPING LAMINATION DARK SPECKS STICKING EXCESSIVE FLASHING COATING CONTAMINENT
19.
© Natoli EngineeringCompany2020. Back
Angle Head Wear Upper Raising Cam …as well as Poor Press Operation & Associated Damage
20.
© Natoli EngineeringCompany2020. Surprisingly,
it’s a dimension that is typically NEVER inspected! A common occurrence…
21.
© Natoli EngineeringCompany2020. How
to Properly Inspect for Tip Wear: Horizontal OpticalComparator OpticalComparator View OpticalComparator Measurement Actual tip wear measurement 0.005”
22.
New Natoli Laser
Vision System automatically checks critical tip wear. © Natoli EngineeringCompany2020. Tip Wear 0.0143
23.
Method for Checking
Die Wear © Natoli EngineeringCompany2020.
24.
Proper Method for
Checking Die Wear to be continued… © Natoli EngineeringCompany2020.
25.
Choose the expertise
and dependability of Natoli Engineering to provide the right solution. © Natoli EngineeringCompany2020. 636.926.8900 | natoli.com | info@Natoli.com THANK YOU!
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