You will discover the topics about the importance of eating the right foods and how it will help banish stubborn belly fat from your body for good, how excess belly fat effects your overall health. Hint, it change more than your appearance, the real truth about losing lower belly fat for a sexy flat stomach some simple, yet effective diet tips that will help you lose excess belly fat and the connection between belly fat and diabetes and how it effects your health.
This document is the copyright page and table of contents for a cookbook focused on recipes to reduce chronic inflammation. The copyright page provides information on copyright, limitations of liability, and trademarks. The table of contents lists over 100 anti-inflammatory recipes organized into sections on smoothies and drinks, breakfast, snacks, soups and stews, salads and sides, vegetarian dishes, seafood dishes, meat and poultry dishes. The recipes aim to help those struggling with chronic conditions by providing anti-inflammatory foods and meals.
ATS Week brought to you by ATS Jr. Companies is a top personal development and training company, begins July 16- July 23. We are providing the best content in training, coaching and personal development. Learn things from selling on eBay to writing a book to overcoming your arrogance, starting a business and so much more! To learn more go to theatsjr.com
ATS Week brought to you by ATS Jr. Companies is a top personal development and training company, begins July 16- July 23. We are providing the best content in training, coaching and personal development. Learn things from selling on eBay to writing a book to overcoming your arrogance, starting a business and so much more! To learn more go to theatsjr.com
This document discusses why investing is important and common motivations for investing. It notes that while goals like building wealth, supporting a family, and preparing for retirement are common motivations, individuals' priorities may differ. It emphasizes that there is a relationship between risk and return - higher risk investments provide the potential for higher returns but also more volatility and potential for loss. The document advises setting attainable investment goals based on factors like time horizon and risk tolerance. It provides historical average annual returns for different asset classes to illustrate this risk-return relationship.
This chapter provides 15 smoothie recipes for breakfast that are healthy alternatives to skipping or eating unhealthy breakfast foods. Smoothies are a convenient breakfast option that can be high in nutrients, protein, good carbs and fats to keep you full until lunch without overeating. The Pumpkin Juice recipe highlights how smoothies can be packed with antioxidants and omega-3s to fuel your day in a delicious way.
Cookbooks best sellers 2014 famous recipes cookbook; rediscover 70 all time ...tapaskumbhakar1
As a preferred client of Afflatus Publishing we strive to provide more value, all the time. As you are now a special part of our family we want to let you in on a little a little secret
All Opinions Are Not Created Equal Critical Reasoning Th.docxgalerussel59292
This document contains a lengthy disclaimer and terms of use agreement for a fictional text. It discusses warranties, limitations of liability, export restrictions, registration requirements, and other legal terms. The document is intentionally absurd and contains many nonsensical clauses and references to avoid actual legal obligations.
The preface to the document discusses how the book is not intended to be used like a traditional textbook, as its goal is to empower critical thinking rather than provide settled facts or principles. It aims to get readers to question assumptions and resist manipulation. The preface also provides context for the book's subject matter and how it differs from more technical fields that rely on standardized methods.
Neuraura aims to improve lives by unlocking the field of neuromodulation with next-generation neurosensors. Neuromodulation is a fast-growing area that can treat neurological, psychiatric and sensory conditions, but current challenges include a poor understanding of brain electrophysiology and risks of overstimulation. Neuraura has achieved 100% seizure detection in animal trials with its technology that aims to advance neuromodulation.
This document is the copyright page and table of contents for a cookbook focused on recipes to reduce chronic inflammation. The copyright page provides information on copyright, limitations of liability, and trademarks. The table of contents lists over 100 anti-inflammatory recipes organized into sections on smoothies and drinks, breakfast, snacks, soups and stews, salads and sides, vegetarian dishes, seafood dishes, meat and poultry dishes. The recipes aim to help those struggling with chronic conditions by providing anti-inflammatory foods and meals.
ATS Week brought to you by ATS Jr. Companies is a top personal development and training company, begins July 16- July 23. We are providing the best content in training, coaching and personal development. Learn things from selling on eBay to writing a book to overcoming your arrogance, starting a business and so much more! To learn more go to theatsjr.com
ATS Week brought to you by ATS Jr. Companies is a top personal development and training company, begins July 16- July 23. We are providing the best content in training, coaching and personal development. Learn things from selling on eBay to writing a book to overcoming your arrogance, starting a business and so much more! To learn more go to theatsjr.com
This document discusses why investing is important and common motivations for investing. It notes that while goals like building wealth, supporting a family, and preparing for retirement are common motivations, individuals' priorities may differ. It emphasizes that there is a relationship between risk and return - higher risk investments provide the potential for higher returns but also more volatility and potential for loss. The document advises setting attainable investment goals based on factors like time horizon and risk tolerance. It provides historical average annual returns for different asset classes to illustrate this risk-return relationship.
This chapter provides 15 smoothie recipes for breakfast that are healthy alternatives to skipping or eating unhealthy breakfast foods. Smoothies are a convenient breakfast option that can be high in nutrients, protein, good carbs and fats to keep you full until lunch without overeating. The Pumpkin Juice recipe highlights how smoothies can be packed with antioxidants and omega-3s to fuel your day in a delicious way.
Cookbooks best sellers 2014 famous recipes cookbook; rediscover 70 all time ...tapaskumbhakar1
As a preferred client of Afflatus Publishing we strive to provide more value, all the time. As you are now a special part of our family we want to let you in on a little a little secret
All Opinions Are Not Created Equal Critical Reasoning Th.docxgalerussel59292
This document contains a lengthy disclaimer and terms of use agreement for a fictional text. It discusses warranties, limitations of liability, export restrictions, registration requirements, and other legal terms. The document is intentionally absurd and contains many nonsensical clauses and references to avoid actual legal obligations.
The preface to the document discusses how the book is not intended to be used like a traditional textbook, as its goal is to empower critical thinking rather than provide settled facts or principles. It aims to get readers to question assumptions and resist manipulation. The preface also provides context for the book's subject matter and how it differs from more technical fields that rely on standardized methods.
Neuraura aims to improve lives by unlocking the field of neuromodulation with next-generation neurosensors. Neuromodulation is a fast-growing area that can treat neurological, psychiatric and sensory conditions, but current challenges include a poor understanding of brain electrophysiology and risks of overstimulation. Neuraura has achieved 100% seizure detection in animal trials with its technology that aims to advance neuromodulation.
Neuraura aims to improve lives by unlocking the field of neuromodulation with next-generation neurosensors. Neuromodulation is a fast-growing area that can treat neurological, psychiatric and sensory conditions, but current challenges include a poor understanding of brain electrophysiology and risks of overstimulation. Neuraura has achieved 100% seizure detection in animal trials with its technology that aims to advance neuromodulation.
MEDICALEAF, WELLNESS FROM NATURE…
For millennia, cannabis has been utilised and revered for its medicinal and psychoactive properties; it is well documented that physicians from ancient cultures around the world used it to treat pain and other ailments.
More recently, scientists have discovered remarkable medicinal effects: in test tubes, the molecule shielded neurons from oxidative stress, a damaging process common in many neurological disorders and provided the well-publicised ‘miracle’ to alleviate symptoms for epilepsy sufferers.
CBD is one molecule from the cannabis plant and hailed as a therapeutic cure-all. Unlike the better-known ‘marijuana molecule’, THC (delta-9-tetrahydrocannabinol), CBD is not psychoactive, meaning it does not get users ‘high’.
Neuraura is developing next-generation neurosensors that are 350x smaller, have 20x higher spatial resolution, and 3x better signal resolution than existing technologies. This will allow more accurate recording and stimulation of brain activity, improving neuromodulation treatments. Neuraura aims to license its sensors to medical device companies and develop its own epilepsy treatment system. It has secured research collaborations and FDA confirmation of its regulatory pathway. Neuraura is seeking a $3 million seed investment to advance its non-clinical business and fund human trials of its epilepsy system.
This document outlines an agreement between Brian K. Purcell, BKP Medical Alliance Corp., and any information package recipients. It establishes that any information or knowledge shared is confidential and proprietary. The agreement prohibits copying, using, or competing with the information for 20 years. It also establishes that BKP Medical Alliance and its vendors have exclusive agreements, and any attempts to contact vendors without permission would breach the agreement. The document defines the corporate structure of BKP Medical Alliance, including board member roles, salaries, bonuses, and stock ownership. It describes that the purpose of the company is to purchase or develop medical facilities using BKP Medical Alliance and Allied Medical Solutions programs and services.
Northern Empire Resources is embarking on the path of becoming a project generator company. A project generator identifies, acquires and completes early stage exploration on properties of merit adding value and understanding of the project prior to seeking joint venture partners. In doing so, the Company can provide its shareholders with significant exposure to numerous exploration programs and projects without suffering the equity dilution associated with running costly later stage programs on a standalone basis.
The Company plans to embrace the current market conditions which have stalled a great number of projects that could be acquired at significant discounts to valuations during better markets. A key consideration will be targeting projects with low holding costs that will allow the Company to establish a broad portfolio of projects that shareholders will have exposure to.
Northern Empire has assembled a talented board of directors and management team that have a collective history of exploration activity as well as capital raising ability in order to develop Northern Empire in to a successful project generator.
Dating advice for_men__a_dating_guide_on_how_to_be_a_better_man__attract_the_...SrinivasBheemankar
This document provides dating advice for men to become better partners and have more fulfilling relationships. It discusses the importance of mastering oneself, understanding women, navigating relationships, and finding purpose in life. The document is divided into multiple parts covering topics like masculine vs feminine energy, different types of men (alpha vs beta males), finding and living one's purpose, understanding what women want, and maintaining healthy relationships. The overall aim is to help men gain clarity, improve themselves, and form connections that are meaningful for both partners.
OKYO Pharma Limited (LSE: OKYO) operates as a life sciences and biotechnology company in the United Kingdom. Its development program includes Chemerin for the treatment of ocular inflammation, dry eye disease, and ocular neuropathic pain; and BAM-8, a non-opiod analgesic. OKYO Pharma Limited is headquartered in London, the United Kingdom.
Apollo Hospitals Enterprise Limited is a leading private healthcare services provider in India with over 6 decades of operations. It operates 71 hospitals with close to 10,000 beds across India and has expanded access to affordable healthcare through various initiatives. Apollo has played a pivotal role in developing the private healthcare sector in India by improving clinical outcomes and attracting medical talent both from India and overseas. Going forward, the company aims to continue its growth through a focus on clinical excellence, digital healthcare, and expansion into underserved markets.
OKYO Pharma (OKYO) is a bio-pharmaceutical company focused on the discovery & development of first-in-class pharmaceutical therapies to treat inflammatory eye diseases including dry eye and ocular pain. OKYO is developing a lipidated chemerin-peptide drug candidate OK-101, designed to target a key ocular receptor controlling inflammation and ocular pain. The drug, developed by a unique proprietary membrane anchored technology, is designed to increase agonist potency and ocular residence time.
FFCON19 Workshop: Anatomy of Global STOs Security Token Offerings (5Ws) (Pe...Craig Asano
April 4-Day 2 of the 2019 Fintech & Financing Conference in Toronto at the Bram and Bluma Appel Salon in downtown Toronto. David Lucatch, CEO, Pegasus Fintech Inc and RJ Reiser, Chief Growth Officer of Polymath cover the ins and outs of conducting a global security token offering (STO) in this educational workshop.
Links
https://pegasusfintech.com/
https://polymath.network/
https://fintechandfunding.com/
https://ncfacanada.org/
This 3 sentence summary provides the high level and essential information from the document:
The document is a public and products liability policy document that outlines the cover provided for legal liability for personal injury and property damage arising from the business, up to the limit of indemnity. It includes definitions of key terms, exclusions from cover, conditions of the policy, and other important policy information. The document sets out the details of the insurance coverage being provided under the policy.
This document provides legal disclaimers and notices for a website that provides information about health insurance plans in Pennsylvania. It states that the website makes reasonable efforts to provide accurate information but is not responsible for errors. It also notes that external links do not imply endorsement and that some content is copyrighted. The notice explains that personal information collected will not be shared or sold and releases the website from liability if any data is accessed without permission.
This document provides a summary of a General and Products Liability Insurance Policy. It outlines important information about the policy, including definitions, insuring clauses, exclusions, claims conditions, and general conditions. It notes that the policy covers legal liability for personal injury, property damage, and advertising injury that occurs during the policy period. It also summarizes information about the insurer QBE, the insurance broker Steadfast, privacy practices, the General Insurance Code of Practice, and dispute resolution procedures.
Canadian Overseas Petroleum Limited: Investor Presentation - October 2022 CHF Investor Relations
COPL is an international oil and gas exploration, development and production
company actively pursuing opportunities in the United States with operations in
Converse County Wyoming, and in sub-Saharan Africa through its ShoreCan joint
venture company in Nigeria, and independently in other countries.
The Company’s Wyoming operations are one of the most environmentally responsible
with minimal gas flaring and methane emissions combined with electricity sourced
from a neighbouring wind farm to power production facilities.
This document summarizes a business insurance policy provided by Zurich. It outlines key details such as the parties involved (Zurich, Steadfast, and the policyholder), how to apply for coverage, duties of disclosure for applicants, and an overview of policy coverage sections including property damage, business interruption, public and products liability, theft, money, glass, general property, machinery, electronic equipment, and employee fraud. The document also provides definitions, conditions, exclusions, and claim procedures that apply to the policy.
This document provides the policy wording for a Steadfast Business Insurance policy. It outlines key details such as the insurer (Zurich), definitions of terms used, general exclusions and conditions, and procedures for making claims. The document contains individual cover sections for property damage, business interruption, public and products liability, theft, money, glass, general property, machinery, electronic equipment and employee fraud.
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
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Neuraura aims to improve lives by unlocking the field of neuromodulation with next-generation neurosensors. Neuromodulation is a fast-growing area that can treat neurological, psychiatric and sensory conditions, but current challenges include a poor understanding of brain electrophysiology and risks of overstimulation. Neuraura has achieved 100% seizure detection in animal trials with its technology that aims to advance neuromodulation.
MEDICALEAF, WELLNESS FROM NATURE…
For millennia, cannabis has been utilised and revered for its medicinal and psychoactive properties; it is well documented that physicians from ancient cultures around the world used it to treat pain and other ailments.
More recently, scientists have discovered remarkable medicinal effects: in test tubes, the molecule shielded neurons from oxidative stress, a damaging process common in many neurological disorders and provided the well-publicised ‘miracle’ to alleviate symptoms for epilepsy sufferers.
CBD is one molecule from the cannabis plant and hailed as a therapeutic cure-all. Unlike the better-known ‘marijuana molecule’, THC (delta-9-tetrahydrocannabinol), CBD is not psychoactive, meaning it does not get users ‘high’.
Neuraura is developing next-generation neurosensors that are 350x smaller, have 20x higher spatial resolution, and 3x better signal resolution than existing technologies. This will allow more accurate recording and stimulation of brain activity, improving neuromodulation treatments. Neuraura aims to license its sensors to medical device companies and develop its own epilepsy treatment system. It has secured research collaborations and FDA confirmation of its regulatory pathway. Neuraura is seeking a $3 million seed investment to advance its non-clinical business and fund human trials of its epilepsy system.
This document outlines an agreement between Brian K. Purcell, BKP Medical Alliance Corp., and any information package recipients. It establishes that any information or knowledge shared is confidential and proprietary. The agreement prohibits copying, using, or competing with the information for 20 years. It also establishes that BKP Medical Alliance and its vendors have exclusive agreements, and any attempts to contact vendors without permission would breach the agreement. The document defines the corporate structure of BKP Medical Alliance, including board member roles, salaries, bonuses, and stock ownership. It describes that the purpose of the company is to purchase or develop medical facilities using BKP Medical Alliance and Allied Medical Solutions programs and services.
Northern Empire Resources is embarking on the path of becoming a project generator company. A project generator identifies, acquires and completes early stage exploration on properties of merit adding value and understanding of the project prior to seeking joint venture partners. In doing so, the Company can provide its shareholders with significant exposure to numerous exploration programs and projects without suffering the equity dilution associated with running costly later stage programs on a standalone basis.
The Company plans to embrace the current market conditions which have stalled a great number of projects that could be acquired at significant discounts to valuations during better markets. A key consideration will be targeting projects with low holding costs that will allow the Company to establish a broad portfolio of projects that shareholders will have exposure to.
Northern Empire has assembled a talented board of directors and management team that have a collective history of exploration activity as well as capital raising ability in order to develop Northern Empire in to a successful project generator.
Dating advice for_men__a_dating_guide_on_how_to_be_a_better_man__attract_the_...SrinivasBheemankar
This document provides dating advice for men to become better partners and have more fulfilling relationships. It discusses the importance of mastering oneself, understanding women, navigating relationships, and finding purpose in life. The document is divided into multiple parts covering topics like masculine vs feminine energy, different types of men (alpha vs beta males), finding and living one's purpose, understanding what women want, and maintaining healthy relationships. The overall aim is to help men gain clarity, improve themselves, and form connections that are meaningful for both partners.
OKYO Pharma Limited (LSE: OKYO) operates as a life sciences and biotechnology company in the United Kingdom. Its development program includes Chemerin for the treatment of ocular inflammation, dry eye disease, and ocular neuropathic pain; and BAM-8, a non-opiod analgesic. OKYO Pharma Limited is headquartered in London, the United Kingdom.
Apollo Hospitals Enterprise Limited is a leading private healthcare services provider in India with over 6 decades of operations. It operates 71 hospitals with close to 10,000 beds across India and has expanded access to affordable healthcare through various initiatives. Apollo has played a pivotal role in developing the private healthcare sector in India by improving clinical outcomes and attracting medical talent both from India and overseas. Going forward, the company aims to continue its growth through a focus on clinical excellence, digital healthcare, and expansion into underserved markets.
OKYO Pharma (OKYO) is a bio-pharmaceutical company focused on the discovery & development of first-in-class pharmaceutical therapies to treat inflammatory eye diseases including dry eye and ocular pain. OKYO is developing a lipidated chemerin-peptide drug candidate OK-101, designed to target a key ocular receptor controlling inflammation and ocular pain. The drug, developed by a unique proprietary membrane anchored technology, is designed to increase agonist potency and ocular residence time.
FFCON19 Workshop: Anatomy of Global STOs Security Token Offerings (5Ws) (Pe...Craig Asano
April 4-Day 2 of the 2019 Fintech & Financing Conference in Toronto at the Bram and Bluma Appel Salon in downtown Toronto. David Lucatch, CEO, Pegasus Fintech Inc and RJ Reiser, Chief Growth Officer of Polymath cover the ins and outs of conducting a global security token offering (STO) in this educational workshop.
Links
https://pegasusfintech.com/
https://polymath.network/
https://fintechandfunding.com/
https://ncfacanada.org/
This 3 sentence summary provides the high level and essential information from the document:
The document is a public and products liability policy document that outlines the cover provided for legal liability for personal injury and property damage arising from the business, up to the limit of indemnity. It includes definitions of key terms, exclusions from cover, conditions of the policy, and other important policy information. The document sets out the details of the insurance coverage being provided under the policy.
This document provides legal disclaimers and notices for a website that provides information about health insurance plans in Pennsylvania. It states that the website makes reasonable efforts to provide accurate information but is not responsible for errors. It also notes that external links do not imply endorsement and that some content is copyrighted. The notice explains that personal information collected will not be shared or sold and releases the website from liability if any data is accessed without permission.
This document provides a summary of a General and Products Liability Insurance Policy. It outlines important information about the policy, including definitions, insuring clauses, exclusions, claims conditions, and general conditions. It notes that the policy covers legal liability for personal injury, property damage, and advertising injury that occurs during the policy period. It also summarizes information about the insurer QBE, the insurance broker Steadfast, privacy practices, the General Insurance Code of Practice, and dispute resolution procedures.
Canadian Overseas Petroleum Limited: Investor Presentation - October 2022 CHF Investor Relations
COPL is an international oil and gas exploration, development and production
company actively pursuing opportunities in the United States with operations in
Converse County Wyoming, and in sub-Saharan Africa through its ShoreCan joint
venture company in Nigeria, and independently in other countries.
The Company’s Wyoming operations are one of the most environmentally responsible
with minimal gas flaring and methane emissions combined with electricity sourced
from a neighbouring wind farm to power production facilities.
This document summarizes a business insurance policy provided by Zurich. It outlines key details such as the parties involved (Zurich, Steadfast, and the policyholder), how to apply for coverage, duties of disclosure for applicants, and an overview of policy coverage sections including property damage, business interruption, public and products liability, theft, money, glass, general property, machinery, electronic equipment, and employee fraud. The document also provides definitions, conditions, exclusions, and claim procedures that apply to the policy.
This document provides the policy wording for a Steadfast Business Insurance policy. It outlines key details such as the insurer (Zurich), definitions of terms used, general exclusions and conditions, and procedures for making claims. The document contains individual cover sections for property damage, business interruption, public and products liability, theft, money, glass, general property, machinery, electronic equipment and employee fraud.
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Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
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Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.