It is becoming increasingly evident that bidirectional signalling exists between the gastrointestinal tract and human brain, often involving the gut microbiota.Insights into this gut-brain crosstalk have revealed a complex communication system that not only ensures the proper maintenance of gastrointestinal homeostasis, but is likely to have multiple effects on motivation, and higher cognitive functions & age related afflictions.

1. Q: What is gut-brain axis
for human health & beat
aging medical Intervention
development ?
Possible Answer:
“The gut–brain axis is the biochemical signaling
that takes place between the gastrointestinal tract
(GI tract) & the central nervous system (CNS)”
Wikipedia
01

2. Beat Aging_Journey
to Twin Bridge (Science &
Arts) . Virtual Team Link:
linkedin.com/cafetwin
02

3. Q: What is gut-brain axis
for human health & beat
aging medical Intervention
development ?
Possible Answer:
“The gut–brain axis is the biochemical signaling
that takes place between the gastrointestinal tract
(GI tract) & the central nervous system (CNS)”
Wikipedia
03

4. Q:
Possible Answer: Of Microbes and Minds: A Narrative
Review on the Second Brain Aging
“The reduction in gut microbiota diversity has also
become one of the hallmarks of aging, and disturbances in its
composition are associated with several (age-related)
neurological conditions, including depression, Alzheimer’s
disease, and Parkinson’s disease. ….”
ANNA PICCA, Et. Al Catholic University of the Sacred Heart,
Rome, Italy . 02 March 2018, www.frontiersin.org
Can the emerging personalized medicine --anti-aging
stem cell translational medicine (2018+) Reduce impact of
health afflictions associated with human aging
(for example, stroke, mental diseases, cancer, others) ?
04

5. Microglia: The Brain’s First Responders
“… ascent of these “other brain cells” (not Neurons) —so dramatic
in fact, that the knowledge has yet to seep into neuroscience
textbooks (2017+) & has only just begun to permeate the field.
This knowledge, some of it described here, likely represents only
the tip of the iceberg.”
Staci Bilbo Ph.D. & Beth Stevens, Ph.D.
www.dana.org (11/29/2017)
05

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Cafetwinshow.waldenthree.netCafetwinshow.waldenthree.net
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7. Beat Aging Collaborative
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Facebook.com/avi.deyFacebook.com/avi.dey
Café Twin Show
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8. The only way to have a friend is to be one.
Ralph Waldo Emerson
Beat Aging_Journey
to Twin Bridge (Science &
Arts) . Virtual Team
Link at linkedin.com/cafetwin
08

9. Crisper Cas9
A new “Breakthrough”
Gene Editing Discovery (2009)
Promises Innovative Biomedical Interventions
2017++
The CRISPR/Cas system is a immune defenseThe CRISPR/Cas system is a immune defense
employed by certain bacteria to fight off invading virusesemployed by certain bacteria to fight off invading viruses
co-discovered by three bio scientists (in 2009 simultaneously,co-discovered by three bio scientists (in 2009 simultaneously,
working individually and via collaborative basic researchworking individually and via collaborative basic research.
Doudna, Charpentier, and Zhang “seminole figures” in this discovery
according to Professor George Church, Harvard University Bio Lab
09

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SynBio Lab On Cloud
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Doudna (Right) and Charpentier (Left) received
2015 Breakthrough Prize in
Life Sciences Awards Ceremony Hosted
By Seth MacFarlane at NASA Ames RC
CRISPR–Cas9 Gene Editing Discovery (2009)CRISPR–Cas9 Gene Editing Discovery (2009)
““I love her intensity …”I love her intensity …”
Doudna at UC BerkleyDoudna at UC Berkley
10

11. Q: What is gut-brain axis
for human health & beat
aging medical Intervention
development ?
Possible Answer:
“The gut–brain axis is the biochemical signaling
that takes place between the gastrointestinal tract
(GI tract) & the central nervous system (CNS)”
Wikipedia
11

12. Q: What is gut-brain axis
for human health & beat
aging medical Intervention
development ?
Possible Answer:
“The gut–brain axis is the biochemical signaling
that takes place between the gastrointestinal tract
(GI tract) & the central nervous system (CNS)”
Wikipedia
Beat Aging_Journey
to Twin Bridge (Science
& Arts) . Virtual Team
Link:
linkedin.com/cafetwin12

13. Beat Aging
SynBio Lab On Cloud
__Café Twin
at Fairfax, VA
Beat Aging Collaborative
Fairfax VA Circles
Urban Hub Crucible
At Mosaic Merrifield
“where people want to be”
Linkedin.com/cafetwin
13