Pine Biotech - a company that merges big -omics data analysis with clinical care and precision applications for Real World Evidence: research & development of new targets and therapeutics, stratified clinical trials, and development of biomarkers for early detection and companion diagnostics. We want to improve patient outcomes and provide tools for researchers and clinicians to have an impact on healthcare.
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Transforming Biomedical Data Analysis
1. Elia Brodsky
CEO & Co-founder
Boston • New Orleans • pine-biotech.com • @PineBiotech • elia@pine-biotech.com
Transforming biomedical data analysis
2. Omics data on many diseases exists or can be generated, a
good integration approach is needed to make it actionable
3. For researches and clinicians that need to make decisions based on multivariate data
analysis, T-Bio is an analysis and discovery tool that modularly conforms to the users needs,
informs with precision metrics, and combines dozens of data types (i.e. molecular data).
4. We merge big -omics data analysis with clinical care and precision applications for Real
World Evidence: research & development of new targets and therapeutics, stratified clinical
trials, and development of biomarkers for early detection and companion diagnostics. We
want to improve patient outcomes and provide tools for researchers and clinicians to have an
impact on healthcare.
6. Stratification in Clinical Trials
• Utilize data from failed or closed projects
• Using Omics features for recruitment
• Molecular markers linked to responders
Molecular indicators in
Clinical Decision Support
• known molecular indicators
• prognostic clues
• acute chronic disease management
• Integration with clinical records
• Integration with phenotypic data
• Big data machine learning and
advanced algorithmic development
Pine Biotech Solutions and Use Cases
Research & Precision Medicine Clinical Management Platform
Targets for therapeutics
• Detection of actionable pathways
• Early detection of adverse effects
• Multi-lab collaborative discovery projects
IN THE LAB IN THE CLINIC
8. Alpha Development
Internal launch of the first alpha
version
Today
Academic Pilots
10 academic pilot projects
First Commercial Project
ACORDA Clinical Trial
DARPA Project
Therapeutic design: virology
Clinical Trials Started
3 validation with clinical cases
Our Traction to Date
2015
2016
2017
9. Case Study
Identifying biomarkers for multiple sclerosis
remission patients based on lipidomics data
Patient
Stratification
• New analysis of data
• Correlation with clinical indicatorsActions
Our analysis of lipidomics data helped re-organize the recruitment for this clinical trial because
we found artifacts in clinical data and identified candidates for companion diagnostics that
would help improve the precise patient selection based on molecular features
Results
10. Case Study
Identifying relationships
between low-frequency
mutations in virus populations
and it’s impact on the spread
of infection. Identification of
actionable methods to deliver
a new therapeutic framework
11. Proposed Clinical Validation Projects
Patient
Stratification
Clinical Decision
Support
In the intersection of research, clinical trials, and healthcare there is a gap of incorporating
omics data into precise diagnostics and therapeutics development to improve and implement
the precision medicine component of the local population health management
Description:
Clinical Trials
12. Business Model
• Pharma companies and large organizations pay $20k-50k per year
• (if applicable) a one time installation fee of $150k
Data Analysis Layer Platform
• Primary Investigators pay based on algorithm access per
cycle (cost plus) and user types
• Integration of new methods or adaptation is separate cost
Research Lab Access
• Precision Medicine Centers pay $150,000 per year
• Installation is a one time fee of $250k - $500k
Clinical Integration
• Pharma Companies pay a custom price based on “packages”
• HPC, Private Cloud and Hybrid Cloud configurations
Pharma Department Solution
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