1. “EFRUZHU CANCER
(CARCİNOGENESİS) THEORY”
ABERRANT SİGNALİNG PATHWAYS AND NORMAL SİGNALİNG
PATHWAYS.DETAİLED COMMENTS 5.
ABERRANT SİGNALİNG PATHWAYS WORKS VİA GUANYLATE CYCLASE
AND GUANOSİNE MONO PHOPHATE MOLECULES ,CONTİNUOUS
NİTRİC OXİDE,CYTOKİNES-GROWTH FACTORS SİGNALİNG FROM
OUTSİDE. DOMİNANTLY CHRONİC İNFLAMMATİON İMMUN CELLS
MACROPAGES,CYTOKİNES AND GROWTH FACTORS MAKE ONTO CELL
PROLİFERATİON AND DİFFERENCİATİON DEPENDENCE OF LİGAND
AMOUNT, HİGH LEVEL-AMAUNT MAKE PROLİFERATİVE=İMMATURE
EFFECT ,LOW LEVEL- NORMAL AMAUNT MAKE DİFFERENCİATİON
=MATURE EFFECT .NORMAL SİGNALİNG PATHWAYS=PHSİOLOGİCAL
NETWORK USİNG ADENYLATE CYCLASE VİA CYCLİC ADENOSİNE
MONO PHOSPHATE DEPENDENCE OF ATP BUT NOT ENOUGH ENERGY
PHOSPHORİLATİON VERY İMPORTANT POİNT THAT
COMFORMATİONAL CHANGED MAKE EFFECT THAT MOLECULES
TURNİNG ACTİVE CONDİTİON.NORMAL DNA SEQUENCE
HYPERMETHLATED CPG İSLANDS İN PROMOTER AREA AND DECREASE
HİSTONE MODİFİCATİONS(SHOULD NOT ENOUGH OPPENED THAT
TRANSCRİPTİON EXPRESSİON NOT ENOUGH ENERGY) SO NORMAL
SİGNALİNG PATHWAYS SHOULD NOT WORK ACTİVELY THAT MEANS
SUPPRESSİON=REPPRESSİON.