This document provides information on heart failure including its physiology, definition, classification, etiology, risk factors, pathophysiology, clinical manifestation, diagnosis, treatment, and differential diagnosis. It discusses the anatomy of the heart and mediastinum. It defines left heart failure with systolic and diastolic types, right heart failure, and high output heart failure. Risk factors for heart failure include aging, family history, unhealthy lifestyle, and underlying heart/lung conditions. Clinical exams may reveal jugular venous distension, lung crackles, edema. Diagnostic tests include BNP, ECG, echocardiogram, and chest x-ray. Treatment involves drugs like ACE inhibitors, ARBs, beta-blockers, di
2. Table of content
Physiology of heart
and defenition of HF
03
Classification of HF
Etiology, risk factor,
patohysiology of HF
Diagnosis and Clinical
Manifestation
3. Table of content
Treatment of HF
07
Diffrential diagnosis
of HF
Defenition, etiology,
pathophysiology RHD
Diagnosis for RHD
6. ANATOMY - Mediastinum
Mediastinum is central, midline thoracic cavity, which is surrounded anteriorly by
sternum, posteriorly by 12 thoracic vertebrae & laterally by pleural cavity.
Mediastinum is divided into superior mediastinum & inferior mediastinum.
• Superior mediastinum
• Above the plane of sternal angle (above 2 nd rib)
• Contains superior vena cava, aortic arch & its branches, trachea,
oesophagus, thoracic duct, vagus and phrenic nerve.
• Inferior mediastinum
• Below the plane of sternal angle
• Further divided into 3 parts - anterior, middle & posterior mediastinum.
• Anterior mediastinum is anterior to the heart
• Middle mediastinum contains the heart and great vessels
• Posterior mediastinum contains everything that is below the posterior
margin of heart i.e. thoracic aorta
9. CARDIAC TERRITORIES
FRONTAL VIEW
• Right border is formed by
right atrium.
• Laterally to right atrium on
left side is right ventricle
(covers most of the anterior
surface of heart)
• Left border - Mainly formed
by left ventricle
• Posterior border is where
most part of left atrium is
located.
• The apex of heart is formed
by left ventricle
Image courtesy - University of Auckland
10. CONDUCTION PATHWAY
• Speed of conduction -
Purkinje > Atria >
Ventricles > AV node
• Pacemakers rhythm
generation - SA (60-
100/min) > AV (40-
60/min) > bundle of
His/Purkinje (20-40/min).
• Pacemaker - Uses calcium
to generate action
potential. Atrial and
ventricular muscle
depolarization is sodium
dependent
Image courtesy : Hole’s human anatomy and physiology , 7 th
edition by Shier
11. CORONARY ARTERIES
• The left coronary artery is
further divided into left
circumflex artery and left
anterior descending artery
aka anterior
interventricular branch
• The right coronary artery
is further divided into
marginal arteries, nodal
arteries & posterior
interventricular branch.
12. CONCEPTS OF PRELOAD, EJECTION FRACTION & CARDIAC OUTPUT
PRELOAD
• Preload is the load on ventricular
muscles at the end of diastole. It
is determined mainly by left
ventricular end diastolic volume &
left ventricular end diastolic
pressure, in other words - by
venous return.
• Increase in preload results in
increase in contractility that in
turn increases stroke volume &
thus increase in ejection fraction
• Chronic increase in preload is
responsible for dilated
cardiomyopathy
13. CONCEPTS OF PRELOAD, EJECTION FRACTION & CARDIAC OUTPUT
STROKE VOLUME
• Stroke volume is the amount of blood that heart pump out with each beat. It is
affected by contractility, afterload & preload
• SV = EDV (End Diastolic Volume) – ESV (End Systolic Volume)
EJECTION FRACTION
• Is the fraction of blood that heart pump out during 1 contraction which
is usually 60- 70% in healthy normal adult
• Ejection Fraction = Stroke volume/End diastolic volume; therefore, EF =
EDV – ESV/EDV
CARDIAC OUTPUT
• Is the amount of blood that heart pump out during 1 minute
• Cardiac output is calculated as: CO = Heart rate * Stroke volume.
14. CONCEPTS OF PRELOAD, EJECTION FRACTION & CARDIAC OUTPUT
AFTERLOAD
• Afterload is the pressure against which heart will work. It is
determined by peripheral arterial resistance
• Chronic increase in afterload (e.g. hypertension, increasing age) will
lead to left ventricular hypertrophy
• Peripheral resistance is calculated as - Blood flow = Pressure /
Resistance (Q=P/R), therefore R = P/Q
19. HEART FAILURE
Basically classified into 3 types
• Left Heart Failure
• Systolic Heart Failure (SHF)
• Diastolic Heart Failure (DHF)
• Right Heart Failure
• Due to increase in resistance to blood flow out
of the right ventricle.
• High Output Heart Failure
• Failure of heart due to persistent high cardiac
output (high stroke volume)
23. RIGHT HEART FAILURE
Due to increase in resistance to blood flow out of the right
ventricle.
Etiology
• Left heart failure (is most common cause).
• Idiopathic pulmonary hypertension (BMPR2 mutation leading to
pulmonary vasoconstriction)
• Pulmonary stenosis or embolization (give thrombolytic to break
embolus in hemodynamically unstable patient)
• Right ventricular infarction (clear lungs, hypotension, JVD
elevation)
• Restrictive cardiomyopathy, Tricuspid or Pulmonary
regurgitation
24. HIGH OUTPUT HEART FAILURE
Failure of heart due to persistent high cardiac output (high stroke
volume)
Etiology
• Hyperthyroidism
• Severe anemia
• Thiamine deficiency (wet beri beri)
• Septic shock
• Arteriovenous fistula (trauma, shunt, Paget disease of bone)
• Obesity
26. What raises my risk for heart failure?
• Aging can weaken and stiffen your heart. People 65 years or
older have a higher risk of heart failure. Older adults are also
more likely to have other health conditions that cause heart
failure.
• Family history of heart failure makes your risk of heart failure
higher. Genetics may also play a role. Certain changes, or
mutations, to genes can make your heart tissue weaker or less
flexible.
• Unhealthy lifestyle habits, such as an unhealthy diet, smoking,
using cocaine or other illegal drugs, heavy alcohol use, and lack
of physical activity, increase your risk of heart failure.
27. What raises my risk for heart failure?
• Heart or blood vessel conditions, serious lung disease, or
infections such as HIV or SARS-CoV-2 raise your risk. This is also
true for long-term health conditions such as obesity, high blood
pressure, diabetes, sleep apnea, chronic kidney disease, anemia,
thyroid disease, or iron overload.
• Black and African American people are more likely to have heart
failure than people of other races, often have more serious
cases of heart failure and experience heart failure at a younger
age
33. LEFT HEART FAILURE
Symptoms
• Poor exercise tolerance, easy fatigability
• Jugulovenous distension, Peripheral swelling (ankle)
• Inspiratory rales, Shortness of breath, Dyspnea - because fluid in
interstitium prevents expansion of lung. edema can narrow the
airways, which produces wheezes during expiration; this
phenomenon is called as Cardiac Asthma.
• Paroxysmal Nocturnal Dyspnea – Difficulty in breathing on laying
down due to increase in venous return. Usually patient
complains of using 2-3 pillows for sleeping. Standing up relieves
symptoms.
• Confusion
34. LEFT HEART FAILURE
Findings
• Cardiomegaly, Jugular venous distension, S3 in SHF (rapid filling
of ventricles), S4 in DHF (atrial contract against stiffened
ventricles).
• Congested lungs, Pulmonary edema (transudate fluid due to
increase in pulmonary capillary hydrostatic pressure).
• If pulmonary capillary rupture then heart failure cells in alveoli
(alveolar macrophage containing hemosiderin)
35. New York Heart Association functional classification based on severity of symptoms and physical activity
36. INVESTIGATIONS
• BNP level – Use in emergent situation when you are not clear about
CHF.
• BNP level – Use in emergent situation when you are not
clear about CHF.
• High level cannot differentiate SHF versus DHF and so
do transthoracic echocardiography
• If the BNP levels remain high after treatment – sign of bad prognosis.
• If BNP is < 100 pg/mL – Heart failure is highly unlikely.
• If BNP is 100-500 pg/mL - Results are uncertain but
suspicious
• If BNP is > 500 pg/ml - Heart failure is highly likely.
37. INVESTIGATIONS
• On X-Ray: Cardiomegaly, Kerley B lines (septal edema), pulmonary
vasculature congestion, air bronchogram
• On ECG - Left ventricular hypertrophy (S wave in V1 + R in V5 or V6 >
35 mm, > 7 large squares).
• ECG might show ischemic heart disease, arrhythmias and ventricular
hypertrophy.
38. RIGHT HEART FAILURE
PHYSICAL FINDINGS
• Jugulovenous distension, Peripheral edema (in ankle)
• Tricuspid valve regurgitation +/-, S3-S4 sound on right side
• No crackles (if RHF is not due to LHF)
• Hepatosplenomegaly (zone 3 – central zone is affected most,
ascites)
• Cyanosis due to decrease in oxygen saturation
39. HIGH OUTPUT HEART FAILURE
SIGNS AND SYMPTOMS
• Breathlessness at rest or on exertion
• Exercise intolerance
• Fatigue
• The signs of typical heart failure may be present including
tachycardia, tachypnea, raised jugular venous pressure,
pulmonary rales, pleural effusion and peripheral edema
• In high output heart failure, patients are likely to have warm
rather than cold peripheries due to low systemic vascular
resistance and peripheral vasodilatation.
50. Laki-laki usia 61 tahun datang ke poli dengan Riwayat DM
lama. Minum glibenclamid fan metformin. Tidak ada obat
lain. Sudah seminggu ini sesak napas saat aktifitas sehari-
hari. Tidur harus setengah duduk 3 hari ini. Kaki pernah
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67. • Low-grade fever does not
require specific treatment
• Fever alone, or fever with
mild arthralgia or arthritis,
may not require NSAIDs but
can instead be treated with
paracetamol
69. Laki-laki usia 61 tahun datang ke poli dengan Riwayat DM
lama. Minum glibenclamid fan metformin. Tidak ada obat
lain. Sudah seminggu ini sesak napas saat aktifitas sehari-
hari. Tidur harus setengah duduk 3 hari ini. Kaki pernah
bengkak. Diberi furosemide dan berkurang. Ronki minimal di
basal. Td 100/60