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Nu Skin is the Premier Anti-Aging Company

                 Scientific innovation has
                 established Nu Skin as a global
                 leader in the nutritional and
                 personal care industries. Our
                 proprietary processes enable us
                 to set new industry standards in
                 anti-aging, with real solutions that
                 exhibit demonstrable results.
Target the Sources of Aging
Vitality Declines With Age

                                         Age-Related Vitality Loss

As we age, our bodies’
ability to effectively
generate and utilize energy
declines, which may rob us


                              Vitality
of youthful vitality.



                                                      Age
A Global Consumer Need

                                                    • 85% of consumers are
                                                      concerned about their energy
                                                      and stamina levels
                                                    • 40% decline in ability to
                                                      concentrate, from age 30 to 60
                                                    • As we age, sexual desire
                                                      declines ~66% in women and
                                                      ~37% in men



Datamonitor: Global Consumer Fatigue Report. April 2009
Age Related Vitality Loss
Three Dimensions:
1. Physical
   (endurance, stamina, r
   esistance to fatigue)
2. Mental
   (cognition, clarity, focu
   s, memory, alertness)
3. Sexual (desire, libido)
What If…?

What if we could elevate
our youthful vitality by
targeting the sources of
age-related vitality
loss?

What if we could slow this
decline, effectively turning
back our clock towards a
more youthful state?
ageLOC Vitality

      Promotes Three Dimensions
      of Vitality:*
                • Physical Vigor
                • Mental Acuity
                • Sexual Drive

                  Reset, Revive, Renew
                  with ageLOC Vitality


* These statements have not been evaluated by the Food and Drug Administration. This
product is not intended to diagnose, treat, cure, or prevent any disease.
ageLOC Vitality Benefits

        • Promotes three dimensions of
          vitality – physical, mental, sexual
        • Raises and sustains baseline
          energy levels
          ―The most significant change for me was the
          complete mental clarity that I had. There was
          no mental fog.‖
                                          Donna Eckwortzel

          ―After trying ageLOC Vitality I was really clear
          and very energetic, but not in a way that I was
          hyperactive.‖
                                         Leslie Gail
Target Audience

        For men and
        women, young and
        old, who feel like they have
        lost their capacity to fully
        engage in the life they
        envision and want to
        reset, revive and renew
        their youthful vitality.
Science
Mitochondria: A Key Source of Youthful Vitality




              Mitochondria             Mitochondria
                           Endoplasmic Reticulum
• Mitochondria are the cellular power plants
  that convert energy from food (Kcals) into a
  form of energy our cells can use—ATP
• ATP fuels all biological functions
• With age, mitochondria number and
  efficiency declines dramatically
• Functional changes in the mitochondria
  have been tied to age-related vitality loss
Mitochondria Highly Concentrated In:
                    Brain


                    Heart




                    Muscle
Latest ageLOC Discovery

Identified and influenced 52 genes
  tied to mitochondrial function.
ageLOC Is All About Balance



   Genes that         Genes that
ACCELERATE aging    promote YOUTH
Restore Youthful Vitality




                        ageLOC Vitality targets the sources of age-related
                        vitality loss by promoting healthy YGC activity.*
* These statements have not been evaluated by the Food and Drug Administration. This
product is not intended to diagnose, treat, cure, or prevent any disease.
ageLOC Science Validated



                Genetics of Aging
                  Symposium
                University of Tokyo
Key Takeaways
• ageLOC science can identify the ultimate
  sources of age-related vitality loss
• ageLOC can target the Youth Gene Cluster
  related to mitochondrial function, the key driver
  of youthful vitality
• ageLOC can reset this Youth Gene Cluster to
  promote youthful vitality
Antiagingpresentation
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Antiagingpresentation

  • 1.
  • 2.
  • 3. Nu Skin is the Premier Anti-Aging Company Scientific innovation has established Nu Skin as a global leader in the nutritional and personal care industries. Our proprietary processes enable us to set new industry standards in anti-aging, with real solutions that exhibit demonstrable results.
  • 5. Vitality Declines With Age Age-Related Vitality Loss As we age, our bodies’ ability to effectively generate and utilize energy declines, which may rob us Vitality of youthful vitality. Age
  • 6. A Global Consumer Need • 85% of consumers are concerned about their energy and stamina levels • 40% decline in ability to concentrate, from age 30 to 60 • As we age, sexual desire declines ~66% in women and ~37% in men Datamonitor: Global Consumer Fatigue Report. April 2009
  • 7. Age Related Vitality Loss Three Dimensions: 1. Physical (endurance, stamina, r esistance to fatigue) 2. Mental (cognition, clarity, focu s, memory, alertness) 3. Sexual (desire, libido)
  • 8. What If…? What if we could elevate our youthful vitality by targeting the sources of age-related vitality loss? What if we could slow this decline, effectively turning back our clock towards a more youthful state?
  • 9. ageLOC Vitality Promotes Three Dimensions of Vitality:* • Physical Vigor • Mental Acuity • Sexual Drive Reset, Revive, Renew with ageLOC Vitality * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
  • 10. ageLOC Vitality Benefits • Promotes three dimensions of vitality – physical, mental, sexual • Raises and sustains baseline energy levels ―The most significant change for me was the complete mental clarity that I had. There was no mental fog.‖ Donna Eckwortzel ―After trying ageLOC Vitality I was really clear and very energetic, but not in a way that I was hyperactive.‖ Leslie Gail
  • 11. Target Audience For men and women, young and old, who feel like they have lost their capacity to fully engage in the life they envision and want to reset, revive and renew their youthful vitality.
  • 13. Mitochondria: A Key Source of Youthful Vitality Mitochondria Mitochondria Endoplasmic Reticulum
  • 14. • Mitochondria are the cellular power plants that convert energy from food (Kcals) into a form of energy our cells can use—ATP • ATP fuels all biological functions • With age, mitochondria number and efficiency declines dramatically • Functional changes in the mitochondria have been tied to age-related vitality loss
  • 15. Mitochondria Highly Concentrated In: Brain Heart Muscle
  • 16. Latest ageLOC Discovery Identified and influenced 52 genes tied to mitochondrial function.
  • 17. ageLOC Is All About Balance Genes that Genes that ACCELERATE aging promote YOUTH
  • 18. Restore Youthful Vitality ageLOC Vitality targets the sources of age-related vitality loss by promoting healthy YGC activity.* * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
  • 19. ageLOC Science Validated Genetics of Aging Symposium University of Tokyo
  • 20. Key Takeaways • ageLOC science can identify the ultimate sources of age-related vitality loss • ageLOC can target the Youth Gene Cluster related to mitochondrial function, the key driver of youthful vitality • ageLOC can reset this Youth Gene Cluster to promote youthful vitality

Editor's Notes

  1. Competitors in the skin care and nutrition industries merely address the signs and symptoms of aging, such as an aging appearance or reduced wellness. ageLOC Science targets the sources of aging (genes), not just the symptoms.
  2. Loss of vitality is one of the first signs of “feeling older” that people notice. read stats
  3. Loss of vitality is one of the first signs of ‘feeling old’ that people mention as they age.
  4. - ageLOC Vitality improves the three dimensions of vitality—physical vigor, mental acuity, and sexual desire— by promoting healthy YGC activity associated with youthful vitality. Through targeting the sources of age-related vitality loss, ageLOC Vitality helps you feel more like you did when you were young.
  5. Inside each of our cells, and throughout our body are tiny “cellular power plants” called mitochondria. They produce cellular energy, the chemical energy of life.Mitochondria are the key source of youthful vitality.
  6. Read slide
  7. There are three key tissues associated with vitality (Brain, Heart, Muscle). They have highly concentrated mitochondria.- Together with our research partners, we discovered that as we age, the activity patterns of YGCs that govern our mitochondria shift, contributing to a loss of vitality.- Mitochondria are most concentrated in the brain, heart, and muscle. As mitochondrial efficacy declines in these organs, they do not act as youthfully. I’m sure we’ve all witnessed this. We have therefore focused our research on these tissues because they are most concentrated with mitochondria.
  8. From the 372 mitochondrial-related genes we identified that changed with age, we affected 52 of these genes as the Mitochondrial Youth Gene Cluster (mtYGC). This represents key genes tied to mitochondrial aging.
  9. ageLOC is all about balance. Our scientific aim is to oppose age-related changes in gene expression. For example, down-regulate genes that accelerate aging and up-regulate genes that promote youth.
  10. - ageLOC Vitality targets the sources of age-related vitality loss.- Remember the natural energy you had ten years ago? Wouldn’t you like to feel that way again?
  11. ageLOC Science has been presented at numerous scientific and academic conferences over the past two years.
  12. Read slide