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WHAT IS THE ENTOURAGE EFFECT
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What is the Entourage Effect and Why is It
So Important?
The entourage effect isn't just for celebrities, but your bud can have it, too!
Posted by:
Nanci Chi-Town on Thursday Mar 17, 2022
What is the entourage effect? Well, it’s not what you get when you become a big Hollywood celebrity. So it’s got nothing
to do with the old hit tv show of the same name.
No, the entourage effect is what you get when you effectively mix THC and CBD remedies. This article aims to explain to
you what the entourage effect is and how you can make it work for you.
An Introduction

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Perhaps you have heard all the trendy talk about CBD and THC. Perhaps you have even heard the term ‘entourage
effect’ being thrown about. It is important first to understand the difference between THC
(https://cannabis.net/blog/medical/what-is-thc-exactly-now-that-you-know-all-about-cbd) and CBD.
THC stands for TetraHydroCannabinol while CBD is short for CannaBiDiol. Both are compounds produced within the
cannabis plant. In fact, there are many different compounds found in the plant, which scientists are just starting to
discover and explore now.
These compounds include terpenes. Terpenes are responsible for the unique smell and taste of different strains.
Terpenes are not just found in the cannabis plant. They are found in common fruits and vegetables also, including
mangoes, for example.
Terpenes (https://cannabis.net/blog/how-to/what-are-terpenes-and-why-are-they-important) play a major role in the
entourage effect, which will be explained in a moment. Different terpenes can produce different effects. For example,
Guaiol, which has a piney aroma, has antioxidant and antiparasitic properties. Myrcene, the terpene found in mango,
has been linked with the mythical ‘couch-lock’. Linalool, which is also found in lavender, helps with depression and
anxiety.
Terpenes can also be identified through the link between their name and their characteristics. For example, a terpene
called Alpha-Pinene is found in pine trees and strains containing this terpene often have a oodsy, pine aroma. Similarly,
strains containing limonene tend to lean to the citrus-y side. Makes it easy to remember!
That was a digression. Back to the differences. Basically THC is the compound that contains psychoactive properties,
while CBD produces many of the same results, without the psychoactive side effects. This is key to understanding the
Entourage Effect.
Did You Know?
That the human body is already well equipped to accept the compounds found in the cannabis plant? It’s true. Inside
our mortal coil beats the endocannabinoid system.

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The endocannabinoid system was discovered only recently. Basically, your body contains two receptors named CB1 and
CB2 which are used to regulate homeostasis. Compounds found in the cannabis plant bind to one or both of these
receptors.
The CB1 receptors are found in the central nervous system and the brain. CB2 receptors are located mostly in the
digestive and immune systems
It is believed that the endocannabinoid system regulates sleep and anxiety, stimulates a healthy appetite, helps both
focus and recovery, and regulates inflammatory and neuropathic pain.
Introducing The Entourage
The term ‘Entourage Effect’ was first coined by Dr. Ethan Russo in 1999, in his published study ‘Taming THC’. To put it
simply, the ‘Entourage Effect’ is a theory which posits that CBD and THC, working in tandem, can mitigate and
compliment, even strengthen, each other's effects.
Now we come back to the compounds. Here is a list of just some of the many compounds found in the cannabis plant:
Tetrahydrocannabinol
Cannabidiolic Acid
Cannabigerol
Flavonoids
Terpenes
Cannabichromene
Cannabidivarin

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Cannabicitran
Tetrahydrocannabivarin
Most of these compounds, excluding flavonoids and terpenes, are referred to as cannabinoids. Terpenes have been
explained. But what are flavonoids? Flavonoids are a group of phytonutrients that aren’t just found in cannabis, but also
throughout the plant kingdom, much like terpenes.
The idea is that the more you mix and match these compounds, cannabinoids, flavonoids and terpenes, the more
effective they will be.
What Are The Benefits Of Having An Entourage?
The healing properties of the different compounds, terpenes and flavonoids found in the cannabis plant are still being
evaluated. On the whole, CBD and THC have been found to effectively treat a variety of afflictions. Combining CBD and
THC may make the treatment even more effective.
Effects and benefits vary from compound to compound. For example, evidence suggests flavonoids can:
Function as an inflammatory
Contribute as an antioxidant
Lower risk of heart disease
Act as a neuroprotective
Evidence suggests terpenes possess medical properties such as:
anticancer
antimicrobial

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antifungal
antiviral
antihyperglycemic
analgesic
anti-inflammatory
antiparasitic
Terpenes and flavonoids are both classified as ‘secondary compounds’.
The reason for the entourage effect has to do with the interaction between the compounds and the endocannabinoid
system. See, it’s all coming together now! Pun not intended.
CBD cannot bind to the CB1 receptor without the presence of THC. THC must first engage with the CB1 receptor, which
in turn allows the CBD to bind to a secondary position on the CB1 receptor. When low concentrations of both cbd and
thc are bound to the CB1 receptor, it can increase the effectiveness of the therapeutic benefits while simultaneously
reducing unpleasant, unwanted side effects like paranoia and anxiety.
That was a chunk! Sounds a little scientific, indeed. Basically, what it means is that for example, when limonene is
working in combination with other cannabinoids, the potential of it’s anti-inflammatory and immune regulating
properties is increased. Another example is pinene, which in combination with THC and CBD, may help combat the side
effect of memory loss or impairment associated with overconsumption.
Following? This brings us to isolates, broad, and full spectrum.
Across The Spectrum
Here are some quick definitions of the aforementioned terms:

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Isolate - contains just one compound or cannabinoid
Broad Spectrum - contains a variety of compounds but no THC
Full Spectrum - contains all the cannabinoids of the hemp plant including THC
Effective ways to consume compounds and cannabinoids for the entourage effect include CBD hemp flower
(https://cbdhemp.direct/collections/cbd-flower), tinctures, gummies and infused beverages.
In Conclusion
There is much more to learn about the Entourage Effect. Some controversy exists as to whether the entourage effect is
a real thing or just a marketing trick. Hopefully this article has been a good jumping off point for you.
Keep in mind a couple tips:
Be careful with your dosage until you have some experience.
Be sure to vet the companies from which you purchase products.
Enjoy your entourage, may it bring you sweet re-leaf!
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(https://cannabis.net/blog/medical/cannabis-for-crohns-disease-works)
Cannabis for Crohn’s Disease Works
Most of the patients diagnosed with Crohn’s disease are under 35, and while it isn’t fatal it can severely impact quality of life and be a source of financial burden.

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(https://cannabis.net/blog/opinion/how-oregon-fought-the-black-market-and-won)
OPINION
How Oregon Fought the Black Market and Won
We have previously discussed why the illegal market persists despite legalization. In essence, “partial legalization” creates opportunities for black market sales.
On paper, legalizing cannabis should eradicate most black market activities. At the very least, it would make it a non-profitable good for large criminal enterprises.

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