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Annals of Clinical and Medical
Case Reports
Case Study Volume 5
ISSN 2639-8109
From Simple Painkiller to an TNF-Alpha Inhibitor and Back Again or Doing Less is
Always More in Geriatrics
Leners JC*
Department of Geriatrician, LTCF, Luxembourg
*Corresponding author:
Jean-Claude Leners,
Department of Geriatrician, LTCF,
Luxembourg, E-mail: lenersj@pt.lu
Received: 11 Dec 2020
Accepted: 29 Dec 2020
Published: 06 Jan 2021
Copyright:
©2021 Leners JC et al., This is an open access article distributed
under the terms of the Creative Commons Attribution License,
which permits unrestricted use, distribution, and build upon your
work non-commercially.
Citation:
Leners JC. From Simple Painkiller to an TNF-Alpha Inhibitor
and Back Again or Doing Less is Always More in Geriatrics.
Annals of Clinical and Medical Case Reports. 2021; V5(6): 1-1.
1. Case Study
A)	 81 y old male in LTCF with primary learning disability
and cervico-dorso-lombarthrosis treated by WHO level 1
painkiller
B)	 During the absence of the GP, the patient was addressed
to a rheumatologist for his known pain: after 3 consulta-
tions with blood tests and Rx (all negative!!), an hypo-
thetical diagnosis of rheumatoid disease was evocated….
(Eular test: 2 pts!!)
C)	 Over 6 months the medications were increased: corti-
coids(prednisone); ledertrexate: with no better results
(VAS 3-4/10 max!), mainly because the patient was fo-
cused on painkiller even when he had difficulties to ex-
press the symptoms and was still rather autonomous
D)	 A last step of therapeutic escalation was the introduction
(due to? poor communication of the patient and language
barrier between both!) of an TNFalpha inhibitor (Enbrel
50 mg 1/week SC)
E)	 After 6 months, with regular blood testing, an urgent call
for visiting the patient indicated: fever, numerous buc-
cal aphthous lesions and bronchopneumonia associated
to diarrhea. Labor results: pancytopenia with leukopenia
1.3 giga/l; neutrophils at 0.38 giga/l; Hb at 9.8 g/dl and
thrombopenia at 39 giga/l
F)	 Urgent treatment plan: isolation of the patient immediate
stop of Enbrel double antibiotic treatment every 2d day:
blood test Patient recovered status quo ante in 1 month!!
2. Conclusions and lessons learned: Patient’s symptoms have
been correlated to complementary investigations Patients with LD
should be accompanied Medical escalation has to be questioned,
but the most important: Less is More in Geriatrics
http://www.acmcasereport.com/ 1
DOI: http://dx.doi.org/10.47829/ACMCR.2020.5604

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From Simple Painkiller to an TNF-Alpha Inhibitor and Back Again or Doing Less is Always More in Geriatrics

  • 1. Annals of Clinical and Medical Case Reports Case Study Volume 5 ISSN 2639-8109 From Simple Painkiller to an TNF-Alpha Inhibitor and Back Again or Doing Less is Always More in Geriatrics Leners JC* Department of Geriatrician, LTCF, Luxembourg *Corresponding author: Jean-Claude Leners, Department of Geriatrician, LTCF, Luxembourg, E-mail: lenersj@pt.lu Received: 11 Dec 2020 Accepted: 29 Dec 2020 Published: 06 Jan 2021 Copyright: ©2021 Leners JC et al., This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and build upon your work non-commercially. Citation: Leners JC. From Simple Painkiller to an TNF-Alpha Inhibitor and Back Again or Doing Less is Always More in Geriatrics. Annals of Clinical and Medical Case Reports. 2021; V5(6): 1-1. 1. Case Study A) 81 y old male in LTCF with primary learning disability and cervico-dorso-lombarthrosis treated by WHO level 1 painkiller B) During the absence of the GP, the patient was addressed to a rheumatologist for his known pain: after 3 consulta- tions with blood tests and Rx (all negative!!), an hypo- thetical diagnosis of rheumatoid disease was evocated…. (Eular test: 2 pts!!) C) Over 6 months the medications were increased: corti- coids(prednisone); ledertrexate: with no better results (VAS 3-4/10 max!), mainly because the patient was fo- cused on painkiller even when he had difficulties to ex- press the symptoms and was still rather autonomous D) A last step of therapeutic escalation was the introduction (due to? poor communication of the patient and language barrier between both!) of an TNFalpha inhibitor (Enbrel 50 mg 1/week SC) E) After 6 months, with regular blood testing, an urgent call for visiting the patient indicated: fever, numerous buc- cal aphthous lesions and bronchopneumonia associated to diarrhea. Labor results: pancytopenia with leukopenia 1.3 giga/l; neutrophils at 0.38 giga/l; Hb at 9.8 g/dl and thrombopenia at 39 giga/l F) Urgent treatment plan: isolation of the patient immediate stop of Enbrel double antibiotic treatment every 2d day: blood test Patient recovered status quo ante in 1 month!! 2. Conclusions and lessons learned: Patient’s symptoms have been correlated to complementary investigations Patients with LD should be accompanied Medical escalation has to be questioned, but the most important: Less is More in Geriatrics http://www.acmcasereport.com/ 1 DOI: http://dx.doi.org/10.47829/ACMCR.2020.5604