1. Tammy A. Butterick, Ph.D.
Curriculum Vitae
Email: butte017@umn.edu
Education
Ph.D. Pharmacology, Dept. of Pharmacology, University of Minnesota, Minneapolis, MN
M.S. Biology, California Polytechnic State University, Pomona, CA
B.S. Medical Microbiology (Medical Technology Option), California Polytechnic State University, Pomona, CA
Research and Teaching Positions
2015 - Fall Semester Graduate Course Lecturer, Nutrition and Genetics (NUTR 5624), Department of Food
Science and Nutrition (FScN), University of Minnesota (UMN)
2015 - Present Faculty Member, The Minnesota Obesity Center, UMN
2014 - Present Vice Chair, Subcommittee on Research Safety, Minneapolis VA Health Care System,
MN
2013 - Present Graduate Program Faculty Member, College of Food Science and Nutrition (CFANS),
UMN
2013 - Present Adjunct Assistant Professor and Graduate, Dept. of FScN, UMN
2012 - Present Health Science Specialist, Minneapolis VA Health Care System, MN
2012 - 2013 Research Associate, Dept. of FScN, UMN
2012 and 2013 Guest Lecturer Special Topics in Nutrition Science (NUTR 8620), Dept. of FScN, UMN
2003 - 2004 Teaching Associate General Microbiology Laboratory (MIC 201). Department of
Biology, California Polytechnic State University (Cal Poly), Pomona, CA
2000 - 2001 Laboratory Technician, Microscopy Core, Avery Research Center, Pasadena, CA
2001 - Winter
Quarter
Undergraduate Teaching Assistant, Medical Parasitology (ZOO 425/425L),
Department of Biology, Cal Poly, Pomona, CA
1998 - 2000 Laboratory Assistant, Coliform Monitoring Section, Metropolitan Water District, La
Verne, CA
Training
Postdoctoral Associate
Dept. of Food Science and Nutrition, UMN and Minneapolis VAHCS
Research focus: neuroscience and neuropharmacology of obesity
PIs: Drs. Catherine Kotz and Charles Billington
Graduate Research Fellowship
National Institute of Health (NIH) -Minorities in Biomedical Research Sciences (MBRS)-Bridges to the Future
Program, Dept. Pharmacology-UMN, MN
PIs: Drs. Colin Campbell, Daniel Romero and Jill Adler Moore
NIH-MBRS Graduate Scholar
California Polytechnic State University, Pomona, CA
PIs: Drs. Jill Adler-Moore and Pamela Sperry
2.
Mentorship Service
2012 - Present McNair-TRIO scholar faculty mentor, UMN,
2013 - Present MBRS scholar faculty mentor, Cal Poly Pomona, CA and Minneapolis VAHCS,
2016 - Present Northstar STEM Alliance faculty mentor, National Science Foundation, UMN
2015 - 2016 Minnesota Academy of Science, faculty advisor Mounds High School, MN and
Minneapolis VAHCS, MN
2011 - 2014 Undergraduate Research Opportunities Program (UROP) professional and
faculty mentor, UMN
Committee Service
2014- Present VA Research Day Planning Chair, Minneapolis VAHCS
2013- 2014 Finance Committee, The Obesity Society
2010- 2012 Senior Scientific Consultant for Minnesota Cancer Survivors Wellness Fund
2008- 2010 Social Chair and founding member, UMN Association of Multicultural Scientists
2001-2004 Student Member, American Society for Microbiology
Professional Membership
2011 - Present The Obesity Society
2007 - Present Society for Neuroscience
2007 - Present Member, Society for Advancement of Chicanos and Native Americans in Science
2008 - 2010 UMN Association of Multicultural Scientists
2001 - 2004 Member, American Society for Microbiology
Invited Seminars and Professional Presentations (2009-2016)
Panelist, McNair –Trio Graduate School Preparation Seminar, UMN
Panelist, Advancing faculty diversity in higher education, College of Continuing Education, UMN
Seminar speaker, Dept. of Medicinal Chemistry, UMN
Presenter, oral abstracts for The Obesity Society and Society for Neuroscience annual meetings
Seminar speaker, Institute for Translational Neuroscience, UMN
Keynote speaker, California State University Program for Education and Research in Biotechnology
Seminar presenter, NIH ADVANCE/MBRS-RISE, Cal Poly-Pomona
Panelist, College Preparation and Achievement Awards, Alpha Kappa Alpha, UMN Chapter
Manuscript Review Service
Acta Physiologica, Acta Theriologica, FEBS Open Bio, Neuroscience Letters, International Journal of Obesity,
PLoSONE, Journal of neuroinflammation, Peptide and Molecular Neurobiology
Grant Review Service
American Heart Association, Portuguese Foundation for Science and Technology and Singapore Ministry of
Health-National Medical Research Council
Ongoing Research Support
Career Development-2 Award (1 IK2 BX001686-01A), Department of Veterans Affairs BLR&D
Dates: 01/01/12-12/31/17
Grant title: Orexin induced gene and protein expression patterns in the rostral lateral hypothalamus (rLH)
Award amount: $782,945.00 Role: PI
Supplement 0161A1award: $20,000.00 (08/09/16 – 08/01/17)
Minnesota Veterans Medical Research & Education Foundation
Dates: 01/25/16-01/25/18
Grant title: Immunomodulatory role of orexin A in cognitive decline and obesity
Award amount: $20,000.00 Role: Lead PI
3.
Completed Support
University of Minnesota (UMN) Healthy Foods, Healthy Lives Institute
Grant title: Brain immune cell response to dietary saturated fatty acid
Role: Graduate Faculty Mentor and Advisor (Ph.D. Student, Cayla M. Duffy)
Award amount: $10,000.00
University of Minnesota (UMN) Healthy Foods, Healthy Lives Institute
Grant title: Air pollution exposure induced neuroinflammation and obesity (awarded, completed)
Award amount: $10,000.00 Role: Lead PI
Shared Equipment Evaluation Program (ShEEP) Proposal (BX003083-01), VAORD
Grant title: Acquisition of a Seahorse XFe96 Extracellular Flux Analyzer
Award amount: $190,693.00 (one time award for equipment cost only). Role: PI
Shared Equipment Evaluation Program (ShEEP) Proposal (IS 1 BX003578), VAORD
Grant title: Acquisition of An EVOS FL Auto Microscope Imaging System
Award amount: $ 111,668.37 (one time award for equipment cost only). Role: PI
Shared Equipment Evaluation Program (ShEEP) Proposal (IS 1 BX000579), VAORD
Grant title: Acquisition of a LICOR Pearl Trilogy Small Animal Imaging System
Award amount: $ 141,481.05 (one time award for equipment cost only). Role: PI
Minneapolis VAHCS Research Services Shared Equipment Grants (one time awards for equipment cost only,
line items 1-6). Role: PI
1. Grant title: Acquisition of a Roche Lightcycler-96 Real Time PCR Cycler
Award amount: $29,200.00
2. Grant title: Acquisition of a LiCOR Odyssey Fc Instrument
Award amount: $ 33,821.00.
3. Grant title: Acquisition of an automated cell counter (Thermo-Fisher COUNTESS II FL)
Award amount: $13,452.00
4. Grant title: Acquisition of a multi-array ELISA reader (Luminex- MAGPIX with xPONENT 4.2)
Award amount: $26,000.00
5. Grant title: Acquisition of a ccomplete mouse Barn’s maze system
Award amount: $10,335.00
6. Grant title: Acquisition of a complete rodent two active avoidance test (GEMINI AVOIDANCE SYSTEM)
Award amount: $15,790.00
Publications (2012-2016)
Duffy CM, Nixon JP, Butterick TA. Orexin A attenuates palmitic acid-induced hypothalamic cell death. Mol
Cell Neurosci. 2016 Jul 21;;75:93-100. doi: 10.1016/j.mcn.2016.07.003. [Epub ahead of print]. PMID: 27449757
Duffy CM, Yuan, C, Ahmed S., Mavanji V., Nixon JP, Butterick TA. Microglia s a Surrogate Biosensor to
Determine Nanoparticle Neurotoxicity.JVis Exp Ms. No.: 54662. Accepted and pending final edits
Gac L, Butterick TA, Duffy CM, Teske JA, Perez-Leighton CE. Role of the non-opioid dynorphin peptide des-
Tyr-dynorphin (DYN-A(2-17)) in food intake and physical activity, and its interaction with orexin-A. Peptides.
2016 Feb;;76:14-8. doi: 10.1016/j.peptides.2015.12.001. Epub 2015 Dec 3. PMID: 26654796.
Hocum Stone L*, Butterick TA*, Duffy C, Swingen C, Ward HB, Kelly RF, McFalls EO. Cardiac Strain in a
Swine Model of Regional Hibernating Myocardium: Effects of CoQ10 on Contractile Reserve Following Bypass
Surgery. J Cardiovasc Transl Res. 2016 May 16. [Epub ahead of print] PubMed PMID: 27184805. *shared 1st
authorship
Butterick TA, Hocum Stone L, Duffy C, Holley C, Cabrera JA, Crampton M, Ward HB, Kelly RF, McFalls EO.
Pioglitazone increases PGC1-α signaling within chronically ischemic myocardium. Basic Res Cardiol. 2016
May;;111(3):37. doi: 10.1007/s00395-016-0555-4. Epub 2016 May 2. PMID: 27138931
4.
Duffy CM, Yuan C, Wisdorf LE, Billington CJ, Kotz CM, Nixon JP, Butterick TA. Role of orexin A signaling in
dietary palmitic acid-activated microglial cells. Neurosci Lett. 2015 Oct 8;;606:140-4. doi:
10.1016/j.neulet.2015.08.033. Epub 2015 Aug 22. PMID: 26306651
Nixon JP, Mavanji V, Butterick TA, Billington CJ, Kotz CM, Teske JA. Sleep disorders, obesity, and aging: the
role of orexin. Ageing Res Rev. 2015 Mar;;20:63-73. doi: 10.1016/j.arr.2014.11.001. Epub 2014 Nov 22.
Review. PMID: 25462194
Holley CT, Long EK, Butterick TA, Duffy CM, Lindsey ME, Stone LH, McFalls EO, Kelly RF. Mitochondrial
fusion proteins in revascularized hibernating hearts. J Surg Res. 2015 May 1;;195(1):29-36. doi:
10.1016/j.jss.2014.12.052. Epub 2015 Jan PMID: 25655995.
Holley CT, Duffy CM, Butterick TA, Long EK, Lindsey ME, Cabrera JA, Ward HB, McFalls EO, Kelly RF.
Expression of uncoupling protein-2 remains increased within hibernating myocardium despite successful
coronary artery bypass grafting at 4 wk post-revascularization. J Surg Res. 2015 Jan;;193(1):15-21. doi:
10.1016/j.jss.2014.08.003. Epub 2014 Aug 8. PMID: 25199570.
Butterick TA, Duffy CM, Lee RE, Billington CJ, Kotz CM, Nixon JP. Use of a caspase multiplexing assay to
determine apoptosis in a hypothalamic cell model. JVis Exp. 2014 Apr 16;;(86). doi: 10.3791/51305. PMID:
24797379
Butterick TA, Billington CJ, Kotz CM, Nixon JP. Orexin: pathways to obesity resistance? Rev Endocr Metab
Disord. 2013 Dec;;14(4):357-64. doi: 10.1007/s11154-013-9259-3. Review. PMID: 24005942
Butterick TA, Nixon JP, Billington CJ, Kotz CM. Orexin A decreases lipid peroxidation and apoptosis in a
novel hypothalamic cell model. Neurosci Lett. 2012 Aug 22;;524(1):30-4. doi: 10.1016/j.neulet.2012.07.002.
Epub 2012 Jul 11. PMID: 22796468
Kotz C, Nixon J, Butterick T, Perez-Leighton C, Teske J, Billington C. Brain orexin promotes obesity
resistance. Ann N Y Acad Sci. 2012 Aug;;1264:72-86. doi: 10.1111/j.1749-6632.2012.06585.x. Epub 2012 Jul
17. Review. PMID:22803681
Cabrera JA*, Butterick TA*, Long EK, Ziemba EA, Anderson LB, Duffy CM, Sluiter W, Duncker DJ, Zhang J,
Chen Y, Ward HB, Kelly RF, McFalls EO. Reduced expression of mitochondrial electron transport chain
proteins from hibernating hearts relative to ischemic preconditioned hearts in the second window of protection.
J Mol Cell Cardiol. 2013 Jul;;60:90-6. doi: 10.1016/j.yjmcc.2013.03.018. Epub 2013 Apr 2. PMID: 23562790.
*shared 1st
authorship
Cabrera JA, Ziemba EA, Colbert R, Anderson LB, Sluiter W, Duncker DJ, Butterick TA, Sikora J, Ward HB,
Kelly RF, McFalls EO. Altered expression of mitochondrial electron transport chain proteins and improved
myocardial energetic state during late ischemic preconditioning. Am J Physiol Heart Circ Physiol. 2012 May
15;;302(10):H1974-82. doi: 10.1152/ajpheart.00372.2011. Epub 2012 Mar 2. PubMed PMID: 22389388
