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1. 2/20/22, 8:52 PM What is Cannabinomics and What Does it Mean for Cannabis Strains in the Future?
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CANNABINOMICS SPECTROMETRY
What is Cannabinomics and What Does it
Mean for Cannabis Strains in the Future?
Cannabinomics may be the best way to identify new strains and phenotypes
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2. 2/20/22, 8:52 PM What is Cannabinomics and What Does it Mean for Cannabis Strains in the Future?
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Posted by:
Lemon Knowles on Sunday Feb 20, 2022
It is the year 2022 where cannabis laws are becoming more flexible by the day and adequate and precise information
about the natural herb is available to all. While we are all grateful for the growth of cannabis laws and regulations there
is still a need for more scientific research about the natural herb. This is why today we will be paying close attention to
cannabinomics and its use in analyzing cannabis varieties.
Read on as we explore what this scientific procedure entails and how its use can be beneficial to the entire cannabis industry
at large.
What is cannabinomics?
It is safe to say that cannabinomics isn’t exactly a word that is commonly used among the majority of cannabis
enthusiasts and this is because it is majorly a scientific term. Cannabinomics refers to the scientific approach of using
mass spectrometry and statistical analysis to differentiate between available cannabis species. In clearer terms, the
scientific process involves the use of analytical processes to identify phytochemical markers that can be used to
differentiate between cannabis varieties.

3. 2/20/22, 8:52 PM What is Cannabinomics and What Does it Mean for Cannabis Strains in the Future?
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The general knowledge among most cannabis users is that the difference in cannabis varieties largely boils down to
whether it is sativa, indica, or a hybrid of both. While this may be fundamentally true, there is still more to the
differences in cannabis varieties than the species they originate from. This is why many cannabis growers and
researchers over time have used THC and CBD concentration as a major marker in differentiating varieties.
The use of THC and CBD as main markers for differentiating cannabis varieties has been quite instrumental both in
terms of research, cultivation, and use. This is because it helps to give the grower and/or user an idea of what to expect
from the herb. However, there is still room for differentiating cannabis varieties beyond just THC and CBD which is
where cannabinomics comes in. The process uses compounds less prominent as THC and CBD to analyze and
differentiate different cannabis varieties.
A closer look at Cannabinomics?
Cannabinoids might be the most talked-about constituent in the cannabis plant matrix owing to their psychoactive and
medicinal effects; yet that doesn’t mean they are the only compounds present in the cannabis plant matrix. Other
important phytochemicals present include terpenes, flavonoids, alkaloids, lignans, phytosterols among others. These
chemicals play special roles in synergistically producing the medicinal effects of cannabis in dealing with pain, metabolic
disorders, neurogenerative disorders, seizures, cardiovascular disorders, and many more. The obvious benefits of this
herb have improved the pace of scientific research into the available varieties of cannabis, how they elicit their effects,
and other possible medicinal effects yet to be discovered. With over 10 articles being published daily, the demand for
scientific literature on cannabis is ever-increasing and proper differentiation and identification of cannabis varieties is
key to meeting this demand.
The science of Cannabinomics
As stated earlier, cannabinomics seeks to utilize numerous metabolites that are less prominent than THC and CBD to
analyze different cannabis varieties. Cannabinomics, therefore, becomes a more comprehensive approach and it is
gradually gaining acceptance in plant science research. The approach uses either liquid chromatography-mass
spectrometry (LC-MS), gas chromatography-mass spectrometry (GC-MS), or nuclear magnetic resonance spectroscopy
(NMR) for detection. The detection and annotation process is also supported by the use of bioinformatics and statistical
analysis to classify the chemotypes and identify other phytochemicals present.

4. 2/20/22, 8:52 PM What is Cannabinomics and What Does it Mean for Cannabis Strains in the Future?
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The scientific procedure of cannabinomics commences with identifying and collecting the plant material to be used. This
is then followed by metabolome analysis using appropriate materials while ensuring good laboratory practices. The
products then go through a data mining process using the available analytical tools. The results obtained from the
analytical tools can be used for genotyping of the cultivars, quantification of main phytocannabinoids
(https://cannabis.net/blog/medical/exploring-cbga-the-mother-of-all-phyto-cannabinoids), and other statistical analysis.
Advantages of cannabinomics over other analytical approaches
Before we delve into the advantages of cannabinomics over other approaches, we need to state some of the hindrances
to the proper identification of phytocannabinoids. Only a few phytocannabinoids are available commercially and those
that are available are very expensive. There are also restrictions by national regulations to some standards which
restricts studies to the use of in-house databases or mass spectral libraries.
The first advantage of cannabinomics over other approaches is that it shows major discriminant compounds between
varieties. Through proper annotation and detection of these compounds, cannabinomics helps to improve and fasten
biological research into such varieties. It also helps in characterizing possible entourage effects of such discriminant
molecules in the varieties being analyzed.
The second advantage of cannabinomics over other analytical approaches is that it helps in unraveling characteristic
markers of different cannabis varieties. While a host of cannabis phytochemicals have been identified, there are still
numerous specific markers of each variety yet to be identified. Cannabinomics unravels such characteristic markers
using independent heatmap analysis and Anova tests.
Cannabinomics also helps to easily classify analyzed varieties depending on quantified phytocannabinoids. There are
different types of phytocannabinoids as they exist as different isomers and the labile nature of their acidic form makes
this classification important for further research purposes.
There are a plethora of other benefits that the use of cannabinomics as a research tool for analyzing cannabis tables
brings to the table. This is why the approach is widely being accepted and increasing in use in different studies aimed at
analyzing the complex matrix of phytochemicals in the cannabis plant.

5. 2/20/22, 8:52 PM What is Cannabinomics and What Does it Mean for Cannabis Strains in the Future?
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Bottom line
There is still much to be achieved using cannabinomics as it applies to the detection and annotation of phytochemicals.
This is because it doesn’t limit analysis to phytocannabinoids alone but instead extends to other compounds like
terpenes, flavonoids, alkaloids, and so on.
The knowledge gained through cannabinomics will be instrumental in cultivating plants with the right chemotype and
genotype needed for food and material purposes. The knowledge from cannabinomics is also important in the
medicinal world as it helps in improving the breeding of cannabis varieties with greater expression of minor
phytocannabinoids. This will further help to correlate therapeutic effects with the perceived entourage effect of such
cannabinoids.
NEW WAYS TO IDENTIFY CANNABIS, READ MORE..
(https://cannabis.net/blog/opinion/if-science-says-sativa-and-indica-are-
the-same-do-we-need-a-new-way-to-identify-cannabis-strain)
IF SATIVA AND INDICA ARE THE SAME, DO WE NEED A NEW WAY TO IDENTIFY WEED?
(https://cannabis.net/blog/opinion/if-science-says-sativa-and-indica-are-the-same-do-we-need-a-new-way-to-identify-
cannabis-strain)
What did you think?

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HOW TO
How to Make Cannabis-Infused Disinfectant at Home (Step-by-Step Guide)

10. 2/20/22, 8:52 PM What is Cannabinomics and What Does it Mean for Cannabis Strains in the Future?
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(https://cannabis.net/blog/how-to/how-to-make-cannabisinfused-disinfectant-at-home-stepbystep-guide)
If you have not been making your own cannabis-infused disinfectant yet – I hope this article inspires you to start. I have been doing this for years and it’s always
great to have it on hand. It works wonders for mosquito bites and immediately alleviates the itching. It’s also got anti-inflammatory properties – albeit, not a
whole lot, as well as anti-bacterial properties.

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NEWS

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(https://cannabis.net/blog/news/could-switzerland-be-the-next-supplier-of-legal-weed-in-europe)
Could Switzerland Be The Next Supplier Of Legal Weed In Europe?
In cannabis fields throughout Switzerland, harvest time is about to end. Crops will soon be distributed to head shops in France and Switzerland, and soon may be
available in other parts of Europe thanks to a business named CBD420.

13. 2/20/22, 8:52 PM What is Cannabinomics and What Does it Mean for Cannabis Strains in the Future?
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(https://cannabis.net/blog/news/give-your-kid-chemo-not-cannabis-oil-mom-goes-to-jail-over-cannabis-legalization)
NEWS
Give Your Kid Chemo, Not Cannabis Oil! Mom Goes to Jail Over Cannabis Legalization
Dixon explained that the chemo didn’t work but when she gave Kylee a combination of CBD oil together with vitamins and herbs, the cancerous tumor saw a
shrinkage of as much as 90%. Despite this, the authorities are still charging her because they CLAIM there is insufficient evidence that cannabis or CBD oil
actually works.
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