Apresentação do AEON pelo DR Steve Haltiwanger. e se o corpo tivesse a solução? saiba mais em www.ondadevida.com

1. LifeWave 2011 Aeon Conference Steve Haltiwanger MD, CCN

2. Prolonged exposure to both physiological and psychosocial stress increases inflammation and the rate of aging among the body’s organ systems (Sapolsky, 1992). A exposição prolongada ao stresse fisiológico e psicossocial aumenta a inflamação e a taxa de envelhecimento entre os sistemas de órgãos do corpo (Sapolsky, 1992).

3. Stress ANS + Biochemical response ANS + Respostabioquímica Silent Chronic Inflammation + Free radical damage InflamaçãoCrónicaSilenciosa+ Lesões dos radicaislivres Cellular Dysfunction DisfunçãoCelular Organ damage Lesõesnosórgãos AgingEnvelhecimento

4. Stress: the reaction of the body and mind to everyday challenges and demands Stress: a reação do corpo e da mente a desafios e exigências do dia-a-dia Both psychological stress and aging activate the Sympathetic Nervous system Tanto o stresse psicológico como o envelhecimento activam o sistema Nervoso Simpático

5. Unhealthy profile Aging increases the activity of the sympathetic nervous system, which in turn increases inflammation and oxidative stress.O envelhecimento aumenta a atividade do sistema nervoso simpático, que, por seu turno, aumenta a inflamação e o stresse oxidativo. Healthy profile HR Perfil saudável Perfilnãosaudável HR “High parasympathetic tone” (Stress resilience) “Low parasympathetic tone” www.nuigalway.ie/childandfamilyresearch/documents/CFRC2010-05-19.ppt «Tom parassimpáticoelevado»(Resiliênciaao stress)‏ «Tom parassimpáticobaixo»

6. Chronic stress leads to pain and fatigue. It also increases immune-mediated inflammation activating inflammatory chemicals, which affect the brain and evoke feelings of malaise, sickness and tiredness (Graham et al., 2006; Ho et al., 2010). O stresse crónico conduz a dor e fadiga. Também aumenta a inflamação relativa à imunidade activando químicos inflamatórios, que afetam o cérebro e motivam sentimentos de mal-estar, doença e cansaço (Graham et al., 2006; Ho et al., 2010). Two of the consistent effects of Aeon patches have been reports of more energy and less pain. Dois dos efeitos consistentes dos adesivos Aeon têm sido os relatos de mais energia e menos dor.

8. Increased Fibrinogen Aumento do Fibrinogénio

9. Increased Homocysteine Aumento da Homocisteína

10. Increased Lipid Peroxides Aumento dos Peróxidos Lipídicos

11. Increase Cytokine Production with an Imbalance of Inflammatory CytokinesAumento da Produção de Citoquinas com um Desequilíbrio das Citoquinas Inflamatórias

13. Oxidative stress Inflammation Inflamaçãoporstresseoxidativo EnvelhecimentoNormal Envelhecimen-to Acelerado Accelerated Aging NormalAging

15. Chronic and continuous inflammation creates oxidative stress, immune system breakdown and communication errors where the body loses it’s ability to distinguish normal cells from foreign invaders. A inflamação crónica e contínua cria stresse oxidativo, quebra do sistema imunitário e erros de comunicação em que o corpo perde a capacidade de distinguir as células normais dos invasores externos.

17. Oxidative stress typically increases with age resulting from increasing free radical productionand declining antioxidant defenses(Sastre et al., 2000). O stresse oxidativo aumenta tipicamente com a idade, devido ao aumento da produção de radicais livres e ao declínio das defensas dos antioxidantes (Sastre et al., 2000). To me this means that using strategies to correct these concerns will be very beneficial in reducing cellular damage and organ deterioration. O stresse oxidativo aumenta tipicamente com a idade, devido ao aumento da produção de radicais livres e ao declínio das defensas dos antioxidantes (Sastre et al., 2000). Aeon – should be used with Glutathione and Carnosine Patches Aeon – deve ser usado com os adesivos Glutathione e Carnosine

19. DNA ADN

20. Protein and Nas Moléculas de Proteína e

21. Lipid molecules (Weinert et al., 2003). Moléculas Lipídicas Genetic damage increases with aging as the levels of oxidant-damaged DNA and protein accumulate (Beckman and Ames 1998). As lesões genéticas aumentam com a idade, à medida que se acumulam os níveis de ADN e de proteína danificados pelos oxidantes (Beckman and Ames 1998).

22. stress Aging Aeon Patches oxidative Cell and organ damage inflammation

23. Moving into Parasympathetic Reduces Stress

26. Fibrinogen, a protein made by the liver, may rise sharply in any condition that causes inflammationor tissue damage. O fibrinogénio, uma proteína produzida pelo fígado, pode subir rapidamente em qualquer condição que cause inflamaçãoou lesão nos tecidos. A high fibrinogen level is significantly associated with coronary artery disease, carotid atherosclerosis and strokes (De Luca et al., 2010; Kwaan, 2010). Um alto nível de fibrinogéniosestásignificativamenteassociadoàdoença da artériacoronária, àaterosclerose da carótida e aosderramescerebrais (De Luca et al., 2010; Kwaan, 2010). These conditions cause 60% of the deaths in the elderly. Estascondiçõescausam 60% das mortes dos idosos.

28. A team of scientists in China compared fibrinogen levels in two family groups, 7 families with a history of long life, compared to 9 families with traditionally shorter life expectancies. Uma equipa de cientistas da China compararam os níveis de fibrinogénio de dois grupos familiares, 7 famílias com uma história de longevidade, em comparação com 9 famílias com uma esperança de vida tradicionalmente mais curta. The scientists concluded that low plasma fibrinogen levels are correlated with longer life (Wang, et al, 1998).Os cientistas concluíram que os níveis baixos de fibrinogénio do plasma estão relacionados com uma vida mais longa (Wang, et al, 1998). Aeon testing showed a trend of lower fibrinogen levels Testes feitos ao Aeon mostraram uma tendência para baixos níveis de fibrinogénio

30. “People with high levels of CRP, one of the cardinal markers of inflammation, were over four times more likely to have heart attacks than those with low levels of CRP (Sinatra, 2004).”«Pessoas com a CRP alta, um dos marcadoresessenciais de inflamação, tinhamquatrovezesmaisprobabilidades de sofrerataquescardíacos do que as quetinhamníveisbaixos de CRP (Sinatra, 2004).” Aeon testing showed a trend of lower CRP levels Testes feitos ao Aeon mostraram uma tendência para níveis de CRP baixos

31. Varying degrees of high levels of homocysteine are detectable in all inflammatory diseases and it is a marker for inflammation (Wu, 2007).Diversosgraus de níveiselevados de homocisteínasãodetetáveisemtodas as doençasinflamatórias, e esteé um marcador da inflamação (Wu, 2007). Acute and Chronic Inflammation Inflamação Aguda e Crónica High homocysteine Homocisteína elevada Via Oxidative stress

33. Heart Coração

34. Kidneys Rins

35. Lungs Pulmões

37. Favors lipid peroxidation and Favorece a peroxidação lipídica e

42. Transport mechanisms and Mecanismos de transporte e

43. Communication signaling.Sinalização da comunicação.This disrupts many cellular processes Istoperturbamuitosprocessoscelulares Aeon testing showed a trend of lower lipid peroxide levels Testes feitos ao Aeon testing demonstraram níveis tendencialmente mais baixos de peróxido lipídico

45. Reduction of Inflammation by AeonRedução da Inflamação através do Aeon Based on our lab study, use of Aeon patches results in the following changes in mediators of inflammation: Com base no nossoestudo laboratorial, o uso dos adesivos Aeon resultanasseguintesmudançasnosmediadores da inflamação: Decreased C-Reactive Protein LevelsRedução dos Níveis de Proteína C-Reativa Decreased Fibrinogen levelsRedução dos níveis de Fibrinogénios Decreased Homocysteine levelsRedução dos níveis de Homocisteína Decreased Lipid Peroxide levelsRedução dos níveis de PeróxidosLipídicos

46. Antioxidants + Anti-inflammatories Glutathione Aeon Carnosine Are Protective

49. Wang X, Wang G, Yang C, Li X. Comparison of plasma fibrinogen level in members of Uygur family of longevity and non-longevity in Xinjiang. Wei Sheng Yan Jiu. 1998 Sep 30;27(5):315-6, 327. Ho RC, Neo LF, Chua AN, Cheak AA, Mak A. Research on psychoneuroimmunology: does stress influence immunity and cause coronary artery disease? Ann Acad Med Singapore. 2010 Mar;39(3):191-6. Graham JE, Robles TF, et al. Hostility and pain are related to inflammation in older adults. Brain Behav Immun. 2006 Jul;20(4):389-400. Finch JM, Joseph J. Homocysteine, Cardiovascular Inflammation, and Myocardial Remodeling. Cardiovasc Hematol Disord Drug Targets. 2010 Nov 11. Lin CP, Chen YH, Leu HB et al. Anti-inflammatory strategies for homocysteine-related cardiovascular disease. Front Biosci. 2009 Jan 1;14:3836-45. Wu JT. Circulating homocysteine is an inflammation marker and a risk factor of life-threatening inflammatory diseases. J Biomed Lab Sci. 2007;19(4):107-112. Miquel J, Ramirez-Boscá A, Soler A, et al. Increase with age of serum lipid peroxides: implications for the prevention of atherosclerosis. Mech Ageing Dev. 1998 Jan 12;100(1):17-24. Bhagwat VR. Relationship of erythrocyte superoxide dismutase, serum lipid peroxides and age. Indian J Med Sci. 1997 Feb;51(2):45-51.

50. Halliwell B, Chirico S. Lipid peroxidation: its mechanism, measurement, and significance. Am J Clin Nutr. 1993 May;57(5 Suppl):715S-724S. Sapolsky R M. Stress, the aging brain, and the mechanism of death. Cambridge, MA: MIT Press, 1992. Pugliese PT. Advanced Professional Skin Care. APSC Publishing, 1991

51. Y-Age Aeon Basic Protocol Rotate through the point locations shown, using an Aeon patch 5-7 days per week. The recommended point locations for Y-Age Aeon follow, but you can experiment with these point locations for Y-Age Glutathione and Y- Age Carnosine as well. Option 1: Conception Vessel 6 (CV6) Location: On the midline of the abdomen, 1.5 cun (the length of the index and middle fingers) below the belly button. Option 2: Governing Vessel 14 (GV14) Location: At the base of the back of the neck, where the C7 vertebra protrudes if you tuck your chin to your chest

52. Option 3: Kidney 3 (KI3) Location: In the depression just behind the inside ankle bone Option 4: Large Intestine 4 (LI4) Location: On the back of the hand, in the web, on the bone of the index finger Option 5: Liver 3 (LV3) Location: On the top of the foot, in the web of the big toe

53. Y-Age Advanced Protocols and Combinations Aging is a complex process resulting from a number of different factors. Therefore, an effective anti-aging strategy must be a comprehensive one that tackles the various causes of aging. Each element of the Y-Age system is designed to provide its own unique anti-aging benefit. Using these patches in combination with one another enhances the affects of each individual product and provides a more complete defense against aging. Keep the following guidelines in mind when combining Y-Age patches: Frequency of Use • Y-Age Glutathione – Five to seven days per week • Y-Age Carnosine – One to three days per week • Y-Age Aeon – Five to seven days per week Wear any TWO patches together on any day of the week on any TWO recommended Y-Age patch locations. Use muscle testing to determine the placements and patches that work best for you.

54. Note: Some people experience strong detoxification symptoms when wearing more than one Y-Age patch at a time. Additionally, some people experience feelings of fatigue when wearing Carnosine or Aeon during the day. With Aeon, this often occurs because the patch has shifted the Central Nervous System to the parasympathetic. If you fall into this category, you may want to consider taking Aeon off for a few hours and wearing Carnosine in the evening only. Basic Recommended Y-Age Patch Locations • Conception Vessel 6 • Conception Vessel 22 • Governing Vessel 2 • Governing Vessel 14 • Heart 7 • Kidney 3 • Large Intestine 4 • Liver 3 • Lung 9 • Spleen 6

55. Y-Age 7 Day Protocol Alternatively, you can choose to follow the recommended Y-Age protocol below for combining all the Y-Age patches. Glutathione and Aeon should be worn during the day (12 hours), seven days per week. Carnosine should be worn at night only; seven days per week.

56. Y-Age 7 Day Protocol Point Locations Bladder 60 Conception Vessel 6

57. Y-Age 7 Day Protocol Point Locations (Continued) Conception Vessel 17 Gallbladder 41

58. Y-Age 7 Day Protocol Point Locations (Continued) Governing Vessel 14 Kidney 1

59. Y-Age 7 Day Protocol Point Locations (Continued) Kidney 3 Kidney 27

60. Y-Age 7 Day Protocol Point Locations (Continued) Large Intestine 4 Liver 3

61. Y-Age 7 Day Protocol Point Locations (Continued) Lung 9 Pericardium 6

62. Y-Age 7 Day Protocol Point Locations (Continued) Spleen 4 Spleen 6

63. Y-Age 7 Day Protocol Point Locations (Continued) Spleen 21 Stomach 36

64. Y-Age 7 Day Protocol Point Locations (Continued) Triple Burner 5

65. Energy Enhancer & Y-Age Aeon In the following protocols, the Energy Enhancer patches promote the flow of energy through the body; while the Aeon patches balance this flow of energy and promote and anti-stress response.

66. Energy Enhancer & Y-Age Aeon (continued).

67. Energy Enhancer & Y-Age Aeon (continued).

68. Energy Enhancer & Y-Age Aeon (continued).

69. Combining Y-Age Aeon and IceWave If you do not find pain relief with IceWave alone, you can try applying an Aeon patch at the midline of the body to enhance the effects of IceWave. This applies whether you are dealing with all over body pain or with a specific area of pain. To use this approach, first apply IceWave according to one of the basic protocols found in the IceWave brochure (i.e., Clock Method, Bracketing Method or one of the placements for whole body pain). Then apply an IceWave patch at one of the recommended points below:

70. Combining Y-Age Aeon and IceWave (continued) Governing Vessel 14 Governing Vessel 4

71. Combining Y-Age Aeon and IceWave (continued) Conception Vessel 17 Over the Belly Button