NSAIDs presentation
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non steroidal anti inflammatory drugs
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NSAIDs presentation
- 3. LEARNING OBJECTIVES: • Drug Profile Study • Definition • Mechanism of action • Pharmacokinetics • Pharmacodynamics • Indication and posology • Interactions and management • Brands available
- 4. NSAIDS: • Nonsteroidal anti-inflammatory drugs (NSAIDs) are available by prescription and over-the-counter (OTC). They are used to relieve fever and pain, such as those associated with headaches, colds, flu, and arthritis. • Examples of prescription NSAIDs include ibuprofen, naproxen, diclofenac, and celecoxib. Ibuprofen and naproxen are also available OTC at lower strengths. • Reference: FDA
- 6. DRUG CLASS: NSAIDS Name of drugs: 1. Ibuprofen 2. Aspirin 3. Diclofenac 4. Ketorolac
- 8. PHARMACODYNAMIC PROPERTIES: DRUG CONTRA-INDICATION SIDE EFFECTS/ADRs PREGNANCY CATEGORY (FDA) LACTATION Common Less Common Rare Excreted in milk During Lactation ASPIRIN Hypersensitivity Hemorrhagic disorders Hemophilia Dyspepsia nausea Dyspepsia Vomiting Ulceration Hematemesis Malena Hepatotoxicity Reye’s syndrome Utricaria Rhinitis Major upper GIT bleeding Hypoprothrombinsa emia Thrombocytopenia D Yes Discontinue IBUPROFEN GIT bleeding Intracranial hemorrhage Thrombocytopenia Coagulation defects Vomiting Rash Nausea Weight gain Abdominal cramps Stomach soreness Bleeding gums Blister Agitation C Yes Discontinue DICLOFENAC Severe renal or hepatic impairment Hypovolemic Dehydration Hemorrhagic diathesis Cerebrovascular bleeding Nausea Constipation Dry mouth Esophagitis Stomatitis Colitis Eructation Pancreatitis C Yes Discontinue KETOROLAC Hypersensitivity Asthma Nasal polyps Bronchospasm Angioedema Peptic ulceration Swelling weight gain (unusual) Headache Gas Bruising High BP Skin rash Sores Ulcers Fainting Depression Dark urine Hallucinations C Yes Discontinue
- 9. INDICATIONS AND POSOLOGY: DRUGS INDICATIONS ROUTE OF ADMINISTR ATION POSOLOGY Neonates Child Adults ASPIRIN To treat pain, and reduce fever or inflammation. It is sometimes used to treat or prevent heart attacks, strokes, and chest pain (angina). Mild to moderate pain; fever; various inflammatory conditions such as rheumatic fever, rheumatoid arthritis and osteoarthritis. By mouth By rectum , 300–900mg every 4–6 hours when necessary; max. 4 g daily 450–900mg every 4 hours (max. 3.6 g daily) IBUPROFE N Mild to moderate pain, pain and inflammation of soft-tissue injuries, pyrexia with discomfort By mouth Child 1–3 months 5 mg/kg 3–4 times daily Child 3–6 months 50 mg 3 times daily; max. 30 mg/kg daily in 3–4 divided doses Child 6 months–1 year 50 mg 3–4 times daily max. 30 mg/kg daily in 3–4 divided doses Child 1–4 years 100 mg 3 times daily; max. 30 mg/kg daily in 3–4 divided doses Child 4–7 years 150 mg 3 times daily; max. 30 mg/kg daily in 3–4 divided doses.
- 10. DRUGS INDICATIONS ROUTE OF ADMINISTRATION POSOLOGY Neonates Child Adults DICLOFENAC SODIUM Inflammation and mild to moderate pain Postoperative Pain Pain and inflammation in rheumatic disease including juvenile idiopathic arthritis By rectum/ mouth By rectum . By intravenous infusion or deep intramuscular injection into gluteal muscle By mouth Child 6 months–18 years 0.3–1 mg/kg (max. 50 mg) 3 times daily Child 6–18 years 0.5–1 mg/kg (max. 75 mg) twice daily for max. 4 days; total daily dose may alternatively be given in 3 divided doses Child 2–18 years 0.3–1 mg/kg once or twice daily for max. 2 days (max. 150 mg daily) Child 6 months–18 years 1.5–2.5 mg/kg (max. 75 mg) twice daily; total daily dose may alternatively be given in 3 divided doses
- 12. BRANDS AVALIABLE: DRUG BRANDS DOSAGE FORM STRENGTH Mfg. by UNIT PRICE ASPIRIN Highest Lowest ANAPRIN ASPIRIN AS GENERIC TABS TABS 300mg 300mg OPAL PHARMACARE 2.08 0.08 DICLOFENAC Highest Lowest ARTIFEN VOLITE INJ INJ 3ml 3ml ABBOT ELITE PHARMA 23.8 3.812 IBUPROFEN Highest Lowest BRUFEDIN RPROFEN SUSP SUSP 100mg/450ml 100mg/450ml ARDIN EPOCH 46.35 80.00 KETOROLAC Highest Lowest DYLAC KETROSAN DROPS DROPS 5ml 5ml DYSONPHARM SANTE 100 107.28
- 13. • References: 1. Martindale 36th Edi. 2. Goodman and Gillman manual of pharmacology and therapeutics 3. A-Z Drug Effects 4. Pharmaguide 2010 5. BNF for children 2011-2012 6. Food and drug administration (FDA) 7. Drugs.com 8. Drug facts and comparison 9. BNF 61 March 2011