transcript. Which of the following are differences between DNA, which makes up the human genome, and RNA, which makes up the SARS-CoV-2 genome? [Select any/all that apply.] DNA is usually double-stranded, while RNA is usually (but not always) single-stranded. RNA uses uracil (U) in place of DNA's thymine (T). Only DNA is capable of complementary base-pairing. RNA nucleotides contain ribose, while DNA nucleotides contain deoxyribose. RNA-directed RNA polymerase copies viral RNA into DNA and simultaneously inserts it into the host cell's genome..