Karen Ashe Commentary - Saido Webinar

9,062 views

Published on

0 Comments
0 Likes
Statistics
Notes
  • Be the first to comment

  • Be the first to like this

No Downloads
Views
Total views
9,062
On SlideShare
0
From Embeds
0
Number of Embeds
8,177
Actions
Shares
0
Downloads
2
Comments
0
Likes
0
Embeds 0
No embeds

No notes for slide

Karen Ashe Commentary - Saido Webinar

  1. 1. Overview • Dr. Saido’s group has generated three lines of mice that do not over-produce APP, each of which overexpresses Aβ with a distinct primary sequence but is otherwise identical to the other two lines. Karen Hsiao Ashe
  2. 2. Useful for advancing our understanding of … • The temporal and spatial patterns of Aβ aggregation in the living brain o Diffuse versus neuritic plaques, especially relative to humans with AD o Aβ oligomers that are associated with plaques, like those which react with OC and NAB61 antibodies o Aβ oligomers that are not associated with plaques, like Aβ*56 and Aβ pores which react with A11 antibodies • The role of distinct Aβ species on cognition o They found no deficit using the water maze • We can increase the sensitivity of the water maze by measuring retention (only acquisition seems to have been measured here) o We find that the water maze produces more reproducible results than the Y maze (motivational variability is greater in Y maze than in water maze) Karen Hsiao Ashe

×