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p21 mechanism slide

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Wafik El-Deiry, MD PhD FACP
Wafik El-Deiry, MD PhD FACP

The slide shows the cellular stress response leading to growth arrest as explained by the induction of the universal cell cycle inhibitor p21(WAF1) by the tumor suppressor p53.

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G1 M S G2 R p53 Direct p21 transcription Inactive CDK T P T-loop ATP 161 14 CDK PSTAIRE NH2 T Y 15 p21 G1 Arrest Cell cycle arrest mediated by p53 target p21 (WAF1) DNA damage El-Deiry et al., Cell 75:817, 1993 5,934 citations as of 4-13 The most highly cited original MS in Cell

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p21 mechanism slide

  • 1. G1 M S G2 R p53 Direct p21 transcription Inactive CDK T P T-loop ATP 161 14 CDK PSTAIRE NH2 T Y 15 p21 G1 Arrest Cell cycle arrest mediated by p53 target p21 (WAF1) DNA damage El-Deiry et al., Cell 75:817, 1993 5,934 citations as of 4-13 The most highly cited original MS in Cell