The 2016 U.S. Startup Outlook report from Silicon Valley Bank reveals a cautious optimism among technology and life science entrepreneurs, who anticipate a tightening capital environment and shifting valuations, with a focus on profitability and fundamentals. Despite challenges in fundraising and talent acquisition, a majority of executives view 2016 business conditions as better than the previous year, albeit with a significant drop in optimism compared to prior years. Overall, while M&A remains a preferred exit strategy, issues like access to skilled labor and regulatory challenges are top concerns for startups.