How to design and conduct a complex literature search

1. How to design and conduct a
complex literature search
Rocio Rodriguez Lopez
30/03/2016

2. 1. Research Question: PICO
P: Population/Disease
Crohn Disease
I: Intervention
Vedolizumab
C: Comparator
O: Outcome

3. 2. Background Literature
•Key papers
•Synonyms
•Drug manufacturer
•Specific Databases
•Introduction and discussion

4. 2. Background Literature
Systematic
Reviews
HTA Reports
DARE
Regulatory Agencies

5. 3. Information resources
• CORE Databases: Medline, Embase, WoS.
• Specific Databases: NORD.
• Grey Literature : Trial Registers.
• Manual Searching, Internet Searching,
Citation Searching.

6. 3.a Bibliographic Databases: Medline
1 Crohn Disease/ (30767)
2 (crohn* or ileocolitis or "inflammatory bowel disease 1" or ((regional or granulomatous or
terminal) adj2 (ileitis or ileitides or enteritis or colitis))).ti,ab. (34122)
3 or/1-2 (41222)
4 (vedolizumab* or entyvio* or LDP02 or GTPL7437 or LDP-02 or MLN-02 or MLN-0002).af. (100)
5 3 and 4 (55)
6 randomized controlled trial.pt. (381906)
7 controlled clinical trial.pt. (88467)
8 random*.ti,ab. (737022)
9 placebo.ab. (156936)
10 clinical trials as topic.sh. (170332)
11 trial.ti,ab. (373881)
12 or/6-11 (1209799)
13 exp animals/ not humans.sh. (3972666)
14 12 not 13 (1099744)
15 and/5,14 (26)

7. 3.c Grey Literature
59% of negative trials
are NOT published
Hopewell S, Loudon K, Clarke MJ, Oxman AD, Dickersin K. Publication bias in clinical trials due to statistical significance or direction of
trial results. Cochrane Database of Systematic Reviews 2009, Issue 1. Art. No.: MR000006.

8. 3.c Grey Literature
CENTRAL
International Associations
and Conferences
Conference Proceedings
Citation Index

9. 4. Essentials