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Duff & Phelps
Duff & Phelps’ valuations assist early-stage companies and
established pharmaceutical and biotech manufacturers in
structuring and executing collaboration arrangements that
meet the needs of all parties. Our valuations support
strategic planning, transaction structuring, negotiations,
financial reporting, and tax planning.
In the current environment, many early-stage companies find
themselves with a rich pipeline of potential products but have
limited resources to fund the expensive, high-risk research
and development needed to bring a product to market.
Creative forms of collaborations are being struck with
established manufacturers seeking to renew their product
pipelines. These involve shared funding of R&D, up-front,
milestone, and royalty payments, and options to acquire assets
of the development-stage company in the future.
Duff & Phelps is experienced in valuing these agreements.
Our valuations employ the Income Approach, Market
Approach, and Cost Approach. Often in valuing early stage
R&D programs, unique terms and structures make it most
appropriate to rely on the Income Approach. We access
multiple sources of industry data as well as our client’s
internal data, to ensure that the valuation employs robust and
defensible assumptions for probabilities of technical,
regulatory, and commercial success, timing, and costs.
Our models are flexible allowing assumptions to be easily
changed to address “what-if” questions. This permits the
valuation to be updated when there is new information and
as uncertainties resolve.
We deliver an independent, objective valuation that is:
yy based on a credible, transparent valuation model and
yy employs realistic, defensible, well-documented
assumptions.
Duff & Phelps’ deep industry experience includes valuations
of more than 4500 compounds, biologics, and vaccines in
various stages of clinical development and marketing over
the last 10 years. The dedicated team of professionals in
our Healthcare and Life Sciences Practice has been
involved in many of the largest transactions within the
pharmaceutical, biotech, generics, diagnostics, and device
industries, as well as performing valuations for numerous
smaller companies and startups.
Valuation of R&D Assets,
Collaborations, and
Licensing Agreements
Duff & Phelps has performed
valuations for many of the
Healthcare and Life Science
industry’s largest transactions.
Andreas Chrysostomou
Global Healthcare and Life Sciences Leader
+1 212 871 5994
andreas.chrysostomou@duffandphelps.com
Rick Schwartz
Managing Director
+1 650 798 5558
rick.schwartz@duffandphelps.com
Contact:
Duff & Phelps
For more information please visit:
www.duffandphelps.com
About Duff & Phelps
As a leading global financial advisory and investment banking firm, Duff & Phelps
balances analytical skills, deep market insight and independence to help clients make
sound decisions. The firm provides expertise in the areas of valuation, transactions,
financial restructuring, alternative assets, disputes and taxation, with more than 1,000
employees serving clients from offices in North America, Europe and Asia.
Investment banking services in the United States are provided by Duff & Phelps
Securities, LLC. Member FINRA/SIPC. Transaction opinions are provided by
Duff & Phelps, LLC. M&A advisory and capital raising services in the United
Kingdom and Germany are provided by Duff & Phelps Securities Ltd., which is
authorized and regulated by the Financial Conduct Authority.
Copyright © 2014 Duff & Phelps LLC. All rights reserved. DP140009
Duff & Phelps - Valuation of R&D Assets, Collaborations, and Licensing Agreements
Valuation of Licensing Agreements and Company Shares
Our client was undergoing a restructuring and needed to value their assets for tax purposes.
They had executed four collaboration agreements with larger pharmaceutical manufacturers
for compounds in preclinical through phase III development. Our client would receive payments
tied to clinical, regulatory, and sales milestones, and royalties tied to sales. Duff & Phelps’
valuation model incorporated contingent development options and a range of pre- and post-
launch scenarios. Additionally, we valued each of the company’s classes of shares based on
these potential success-driven cash flows.
Representative Engagements
Joint Venture R&D Strategy
A joint venture between a generic
manufacturer and a drug delivery innovator
had reached an important juncture. Having
demonstrated technical success in early
development efforts and potential use
in three therapeutic areas, it was time
to choose where to invest further effort.
Duff & Phelps conducted market research
with potential adopters and drew upon our
extensive industry data to develop credible,
market projections for each of the three
products. Based on our work, the partners
gained insight into key issues for product
development and a quantitative view of value
and risk for each product option.
Asset Sale and Tax-Driven Restructuring
Upon successful sale of its key drug
undergoing phase II clinical trials, our client
planned to restructure. The proposed terms
of the sale included payments contingent
upon developmental, regulatory, and sales
milestones. We valued the asset based on
expected (probability-weighted) milestone-
driven cash flows. The analysis reflected the
unique attributes of the company’s product and
was benchmarked by industry data on attrition
rates and sales. Our preliminary analysis led the
client to revise the terms in order to mitigate tax
consequences of the restructuring.
2011
2012
2013
2014
2015
2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
2032
2033
2034
2035
2036
2037
2038
2039
2040
$50,000
$150,000
$200,000
$250,000
$300,000
CumulativeCashPayments(ThousandsofUSD)
Phase III Completion
(Potential Milestone Earned)
Potential Product Launch
(Royalties Begin)
Phase II Completion
(Potential Milestone Earned)
Series A Series B Series C Series D Common
Cumulative Expected Payments to Investors
$100,000

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DP Value RD Assets Collab Licensing

  • 1. Duff & Phelps Duff & Phelps’ valuations assist early-stage companies and established pharmaceutical and biotech manufacturers in structuring and executing collaboration arrangements that meet the needs of all parties. Our valuations support strategic planning, transaction structuring, negotiations, financial reporting, and tax planning. In the current environment, many early-stage companies find themselves with a rich pipeline of potential products but have limited resources to fund the expensive, high-risk research and development needed to bring a product to market. Creative forms of collaborations are being struck with established manufacturers seeking to renew their product pipelines. These involve shared funding of R&D, up-front, milestone, and royalty payments, and options to acquire assets of the development-stage company in the future. Duff & Phelps is experienced in valuing these agreements. Our valuations employ the Income Approach, Market Approach, and Cost Approach. Often in valuing early stage R&D programs, unique terms and structures make it most appropriate to rely on the Income Approach. We access multiple sources of industry data as well as our client’s internal data, to ensure that the valuation employs robust and defensible assumptions for probabilities of technical, regulatory, and commercial success, timing, and costs. Our models are flexible allowing assumptions to be easily changed to address “what-if” questions. This permits the valuation to be updated when there is new information and as uncertainties resolve. We deliver an independent, objective valuation that is: yy based on a credible, transparent valuation model and yy employs realistic, defensible, well-documented assumptions. Duff & Phelps’ deep industry experience includes valuations of more than 4500 compounds, biologics, and vaccines in various stages of clinical development and marketing over the last 10 years. The dedicated team of professionals in our Healthcare and Life Sciences Practice has been involved in many of the largest transactions within the pharmaceutical, biotech, generics, diagnostics, and device industries, as well as performing valuations for numerous smaller companies and startups. Valuation of R&D Assets, Collaborations, and Licensing Agreements Duff & Phelps has performed valuations for many of the Healthcare and Life Science industry’s largest transactions.
  • 2. Andreas Chrysostomou Global Healthcare and Life Sciences Leader +1 212 871 5994 andreas.chrysostomou@duffandphelps.com Rick Schwartz Managing Director +1 650 798 5558 rick.schwartz@duffandphelps.com Contact: Duff & Phelps For more information please visit: www.duffandphelps.com About Duff & Phelps As a leading global financial advisory and investment banking firm, Duff & Phelps balances analytical skills, deep market insight and independence to help clients make sound decisions. The firm provides expertise in the areas of valuation, transactions, financial restructuring, alternative assets, disputes and taxation, with more than 1,000 employees serving clients from offices in North America, Europe and Asia. Investment banking services in the United States are provided by Duff & Phelps Securities, LLC. Member FINRA/SIPC. Transaction opinions are provided by Duff & Phelps, LLC. M&A advisory and capital raising services in the United Kingdom and Germany are provided by Duff & Phelps Securities Ltd., which is authorized and regulated by the Financial Conduct Authority. Copyright © 2014 Duff & Phelps LLC. All rights reserved. DP140009 Duff & Phelps - Valuation of R&D Assets, Collaborations, and Licensing Agreements Valuation of Licensing Agreements and Company Shares Our client was undergoing a restructuring and needed to value their assets for tax purposes. They had executed four collaboration agreements with larger pharmaceutical manufacturers for compounds in preclinical through phase III development. Our client would receive payments tied to clinical, regulatory, and sales milestones, and royalties tied to sales. Duff & Phelps’ valuation model incorporated contingent development options and a range of pre- and post- launch scenarios. Additionally, we valued each of the company’s classes of shares based on these potential success-driven cash flows. Representative Engagements Joint Venture R&D Strategy A joint venture between a generic manufacturer and a drug delivery innovator had reached an important juncture. Having demonstrated technical success in early development efforts and potential use in three therapeutic areas, it was time to choose where to invest further effort. Duff & Phelps conducted market research with potential adopters and drew upon our extensive industry data to develop credible, market projections for each of the three products. Based on our work, the partners gained insight into key issues for product development and a quantitative view of value and risk for each product option. Asset Sale and Tax-Driven Restructuring Upon successful sale of its key drug undergoing phase II clinical trials, our client planned to restructure. The proposed terms of the sale included payments contingent upon developmental, regulatory, and sales milestones. We valued the asset based on expected (probability-weighted) milestone- driven cash flows. The analysis reflected the unique attributes of the company’s product and was benchmarked by industry data on attrition rates and sales. Our preliminary analysis led the client to revise the terms in order to mitigate tax consequences of the restructuring. 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 2026 2027 2028 2029 2030 2031 2032 2033 2034 2035 2036 2037 2038 2039 2040 $50,000 $150,000 $200,000 $250,000 $300,000 CumulativeCashPayments(ThousandsofUSD) Phase III Completion (Potential Milestone Earned) Potential Product Launch (Royalties Begin) Phase II Completion (Potential Milestone Earned) Series A Series B Series C Series D Common Cumulative Expected Payments to Investors $100,000