1. OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015)
BIOGRAPHICAL SKETCH
Provide the follow ing information for the Senior/key personnel and other significant contributors.
Follow this format for each person. DO NOT EXCEED FIVE PAGES.
NAME: Peter B. Raven
eRA COMMONS USER NAME (credential, e.g., agency login): PRAVEN
POSITION TITLE: Professor
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing,
include postdoctoral training and residency training if applicable. Add/delete rows as necessary.)
INSTITUTION AND LOCATION
DEGREE
(if
applicable)
Completion
Date
MM/YYYY
FIELD OF STUDY
University of Exeter, England Teach Cert. 1965 Education
University of Oregon, Eugene, OR B.S. 1966 Physical Education
University of Oregon, Eugene, OR M.S. 1967 Scientific Basis of P.E.
University of Oregon, Eugene, OR Ph.D. 1969 Exercise Physiology
University of California, Santa Barbara, CA Post-Doc 1969-70 Aging-NICHD
Please refer to the Biographical Sketch sample in order to complete sections A, B, C, and D of the
Biographical Sketch.
A. Personal Statement
I am currently a Professor in the Department of Integrative Physiology, UNTHSC and have 41 years of
experience in directing Human Integrative Physiological Research as a Principal Investigator funded by
NIEHS, NIOSH, NHLBI, USAF and NASA. I joined the UNTHSC (Nee TCOM) faculty in 1977 with Department
of Energy funding from Los Alamos National Laboratories to identify the Physiological limitations of the Man-
Industrial Respirator interface during exercise. In collaboration with W. P. Morgan at the Univ. of Wisconsin,
Madison and funded by NIOSH results from this research enabled us to establish respirator performance
criteria for the National Firefighters Association. Since 1984 I have focused my research on investigating
arterial baroreflex control of blood pressure during exercise, orthostasis and following exercise training and
detraining (see references below). In support of this work I was funded continuously by NHLBI from 1984 to
2007. More recently I investigated another avenue of research in an attempt to understand the role of the
“intermittent hypoxia induced sympathetic activation of the sleep apnea patient’s resultant hypertension”.
However, my current application returns my focus to identifying the signaling mechanisms involved in exercise
induced arterial baroreflex resetting and the pathophysiological mechanisms of “Exercise Induced
Hypertension (EIHt)”, This proposed investigation requires clinical collaboration with a long-time colleague
Dr. Al. O Yurvati a Board Certified cardio-thoracic surgeon of UNTHSC and an external consultant, Dr Matthew
Zimmerman, providing measurement and interpretation of Free Radicals using electron paramagnetic
spectroscopy (EPR).Other collaborating investigators include Drs Michael Smith (MSNA measurement),
Robert Mallet (Biochemical and Endocrinological measures) and Shande Chen (Biostaistician) and an external
consultant cardiologist Dr. Paul Bhella (recruitment of patients). In addition, one DO/Ph.D. graduate student
and one Ph.D. graduate student mentored by Dr. Raven plus one Research associate to be appointed
complete the research team for the proposed project. With my PI experience, the support of the research team
and our unique customized software and hardware equipment, I fully anticipate successful completion of the
project. Further support for success of the proposed project is the historical collaborations of the PI with other
PIs at UT Southwestern Medical Center, TX. U. of Missouri in Columbia, MO.,U. of Copenhagen in

2. Copenhagen, DK., The Baker Heart Institute in Melbourne, Australia, Toya University in Tokyo, Japan and the
University of Birmingham in Birmingham, UK.
B. Positions and Honors
Positions and Employment
1970–1975 Assist. Res. Prof.(1970-1973); Assoc. Res.
Professor (1973-1975) Inst. of Environ. Stress at UCSB
1975-1977 Inst. of Aerobics Research, Research Director Environ. Section, Dallas, TX
1977 Chair (1994-2001); Acting Chair (1993-1994); Profess (2005-present),
Assoc. Prof. (1977-1986), UNTHSC
2008–2009 Interim, Assist. Dean, Graduate School of Biomedical Sciences, UNTHSC
2008–2011 Joint Professor, Dept. of Orthopedic Surgery, TCOM/JPS, UNTHSC
1995 - Member and Director (1995 – 2001), CV Res. Inst., UNTHSC
1993 – Member, Graduate Faculty, GSBS, UNTHSC
2003 – Visiting Prof. DaCRA -University of Copenhagen Faculty of Health Sciences
Copenhagen, DK.
1979–1993 Graduate Faculty, U. of North Texas, Denton, TX
1977-1988 Visiting Professor, Dept. of HPE&D, TWU, Denton, TX 76203
1979-1987 Visiting Research Professor, VAHospital/UTSWMC, Dallas, TX
Other Experience and Professional Memberships:
1981-present American Heart Association/Texas Affiliate
1979-present American College of Sports Medicine - Texas Chapter Founder; Past President (1979),
Executive Secretary (1980-84), Executive Director (1990-93)
1971-present American College of Sports Medicine - Fellow; Vice President (1982-84), President-Elect (1986-
87) President (1987-88), Past President (1988-present)
1971-present American Physiological Society.
2004-present The Physiological Society
Honors
2013 Legend of ACSM
2011-present Member of NASA/JSC-HRP-SRP member, NASA
2012 Texas ACSM Service Award, Texas Chapter-American College of Sports Medicine
2011 Honor Award: Exercise and Environmental Section of the American
Physiological Society
2008 Invited member of NASA’s Space Board National Science Foundation/National Academy of
Science
2006 Benjamin L. Cohen, DO. Award for Outstanding ResearchAchievement 2005 -2006
2001 KORRAward for Exemplary Commitment to Basic Science Research. Presented by the Bureau
of Research of the American Osteopathic Association, San Diego, CA, October 23, 2001
1996 Presidential Lecture, American College of Sports Medicine, Annual Meeting, Cincinnati, Ohio,
May 31st, 1996
1995 Citation Award American College of Sports Medicine
1993 TACSM Honor Award
1992 Chair of the Heart and Vascular Working Committee for the 2nd International Consensus
Symposium on Physical Activity, Fitness and Health, Toronto, Canada, May, 1992.
1989 ACSM Representative to the President’s Council on Physical Fitness Exchange visit to Moscow
and Leningrad, USSR.
1988 Presidential Lecture Southeast Regional Chapter of ACSM, Winston-Salem, NC, January 1988.
1987-1988 President, American College of Sports Medicine
1987 Presentation David Bruce Dill Annual Lecture, Southwest Regional Chapter of ACSM, Las
Vegas, NV.
1986 Peter B. Raven Lecture named as the Keynote Address at the annual meeting of the Texas
Chapter of the American College of Sports Medicine.
1986 Co-Recipient with W.P. Morgan of John M. WhiteAward for Best Paper on Respiratory
Protection in 1985. Presented by the American Industrial Hygiene Association, May 1986

3. 1969-1971 Postdoctoral Trainee, National Institutes of Health.
1965-1967 Foreign Student Scholarship, University of Oregon
1965 Honor Student Award, St. Luke’s College, University of Exeter, England.
C. Contributions to Science
i ) In the first 10 years (1970 – 1979) of my research career, the first three years being supported by a NIH-
NRSA Post-Doctoral training grant directed by Steven M. Horvath, I published 14 first author and 15 co-
authored peer reviewed, 9 non-peer reviewed and 4 lay manuscripts. The primary focus of my research was on
exercise performance in environmental stressors of heat, cold, air pollution and wearing self-contained
breathing respirators. Much of this work was funded by NIEHS and/or the Cal. Air Resources Board. Two
publications of note influenced the future development of my career:
1. Morgan, WP, PB Raven, BL Drinkwater and SM Horvath. “Perceptual and metabolic responsivity to
standard bicycle ergometry following various hypnotic suggestions” Int. J. of Clin. Exp. Hypnosis. 21:86-
101, 1973.
A study into the manipulation of Central Command
2. Raven, PB, AT Dodson and TO Davis. The Physiological consequences of wearing Industrial
Respirators: A Review. Am. Ind. Hygiene Assoc. J. 40: 517-534, 1979.
The outcomes of this respirator research formed the basis of the next ten years of research into
the limitations imposed on Firefighters wearing SCBAs.
In the next ten years, (1980 – 1989) I published 30 first or major authors, 5 co-authored peer reviewed
publications plus 8 of 9 first-authored non –peer reviewed scientific and 5 lay publications.
ii ) A landmark publication, in which we used clinical anxiety assessments to predict psychological distress
during respirator wear, received the AIHJ- John M. White for excellence in Respiratory Protection. This
work resulted in our total published work on respirator wear (17 peer reviewed publications) providing a
foundation for the NIOSH/OSHA revising performance guidelines for SCBA wear during emergencies (Fire,
Mine Rescue, Noxious Atmospheres etc.).
3. Morgan, WP and PB Raven. Prediction of distress for individuals wearing industrial respirators. Amer.
Ind. Hyg. Assoc. J. 46:363-368, 1985.
4. Wilson, JR, PB Raven, WP Morgan, SA Zinkgraf, RG Garmon and AW Jackson. Effects of Pressure-
Demand respirator wear on physiological perceptual variables during progressive exercise to maximal
levels. Amer. Ind. Hyg. Assoc. J. 50: 85-94, 1989.
5. Wilson, JR, PB Raven, SA Zinkgraf, WP Morgan and AW Jackson. Alterations on physiological and
perceptual variables during exhaustive endurance work while wearing a pressure-demand respirator.
Amer. Ind. Hyg. Assoc. J. 50: 139-146 1989.
iii ) In this second decade of my career I was stimulated by two pre-eminent clinical integrative physiologists,
Jere Mitchell, MD and Gunnar Blomqvist, MD, to explore autonomic neural control (ANC) of arterial blood
pressure during exercise in exercise trained and untrained humans. A path I have followed for the past 35
years. Initially our work employed lower body negative pressure (LBNP) or head-up tilt (HUT) as the autonomic
challenge and resulted in a total of 18 peer reviewed publications.
6. Raven PB, M. Saito, FA Gaffney and CG Blomqvist. Interactions between surface cooling and LBNP
induced central hypervolemia. J. Aviat. Space Environ. Med. 51:497-503, 1980.
7. Raven PB, D. Rohm-Young and CG Blomqvist. Physical fitness and cardiovascular response to lower
body negative pressure. J. Appl. Physiol. 56: 138-144, 1984.
8. Raven PB, K Klein, M Smucker, JH Mitchell and JV Nixon. The effect of cardiac autonomic blockade of
ventricular responses to changes in cardiac preload. J. auto. Nerv. syst. 13:263-272, 1985.
9. Smith, ML and PB Raven. Cardiovascular responses to lower body negative pressure in endurance and
static exercise trained men. Med Sci. Sports and Exerc. 18:505 – 508, 1986
10. Smith, ML, DL Hudson, HM Graitzer and PB Raven. Blood pressure regulation during cardiac
autonomic blockade: Effect of fitness. J. Appl. Physiol. 65: 1789-1795, 1988.

4. 11. Pawelczyk, JA and PB Raven. Reductions in central venous pressure improve carotid baroreflex
responses in conscious men. AJP-Heart 257: H1389-1395, 1989
iv ) In 1985 a young James Pawelczyk joined my research group and proceeded to develop the hardware and
software and constructed a customized neck pressure (NP) neck suction (NS) computerized system to
selectively stimulate the carotid baroreceptors of humans during HUT, LBNP and dynamic exercise (see
reference #6 above).
In the decade of the 1990s I published 39 peer reviewed (7 of which were not focused on ANC of the CV
system) and 15 non-peer reviewed book chapters (13 of which were focused on the ANC of the CV
system).
12. Raven PB and JA Pawelczyk. Chronic endurance exercise training: a condition of inadequate blood
pressure regulation and reduced tolerance to LBNP. MSSE 25:713-721, 1993
13. Williamson, JW and PB Raven. Unilateral carotid-cardiac baroreflex responses in humans. AJP-Heart
265: H1033-H1037, 1993
14. Potts, JT, XR Shi and PB Raven. Carotid baroreflex responsiveness during dynamic exercise in
humans. AJP-Heart 265:H 1928-H 1938, 1993
15. Williamson, JW, JH Mitchell, HL Olesen, PB Raven and NH Secher. Reflex increase in blood pressure
induced by leg compression in man. J. of Physiol. 4745.2:351-357, 1994.
16. Crandall, CG, KA Engelke, VA Convertino and PB Raven. Aortic baroreflex control of heart rate after
15-days of simulated microgravity exposure. J. Appl. Physiol. 77:2134-2139, 1994.
17. Potts, JT, X Shi and PB Raven. Cardiopulmonary baroreceptors modulate carotid baroreflex control of
heart rate during dynamic exercise in humans AJP-Heart 268: H1567-H1576, 1995.
18. Smith, SA, KM Gallagher, KH Norton, RG Querry, RM Welch-O’Connor and PB Raven. Ventilatory
responses to dynamic exercise elicited by intramuscular sensors. MSSE 31: 277-286, 1999.
19. Norton, KH, R. Boushel, S. Strange, B. Saltin and PB Raven resetting of the carotid arterial baroreflex
during dynamic exercise in humans. J. Appl. Physiol.87: 332-338, 1999.
v ) In the 1990s our manuscripts #17 and #19 above established that the operating point (OP) pressure of
the arterial baroreflex was progressively reset to a higher arterial pressure that was directly related to the
increasing work intensity of an exercise stress test. 20 - 25% of individuals that are referred for exercise
stress testing have a negative test but exhibit exercise induced hypertension (EIHt). These patients have a
five year prognosis of being diagnosed with essential hypertension. While normotensive patients at rest
that exhibit EIHt have a 2-3 fold increased risk for the development of hypertension and a greater
prevalence of left ventricular hypertrophy.
Hence, beginning in the year 2000 I have focused my investigations on identifying the primary physiological
ANC mechanisms (Central Command-CC and the Exercise Pressor Reflex-EPR) involved in the exercise
induced resetting of the arterial baroreflex. It is clear from our work that one or both of the ANC
mechanisms need to be activated for baroreflex resetting to occur. Furthermore, the degree of resetting is
modulated by increases or decreases in central blood volume. Between the years 2000-2015 I published
71 peer reviewed manuscripts. The bulk this work provides me the background evidence for this current
NIH proposal intended to identify the physiological and pathophysiological signaling mechanism(s) involved
in arterial baroreflex resetting during exercise. This work is summarized in the following reviews.
20. Fadel, PJ, and PB Raven, Human investigations into arterial and cardiopulmonary baroreflexes during
exercise. Experimental Physiology 97.1: 39-50, 2012
21. Raven, PB and MW Chapleau Blood pressure regulation XI: overview and future research directions.
Eur .J. Appl. Physiol.114:: 579-586, 2014.
22. Michelini, LC, D. O’Leary, PB Raven and Antonio C. L. Nobrega. Neural control of the circulation in
exercise: A translational approach disclosing interactions between central command, arterial baroreflex
and muscle metaboreflex (an invited review in revision) AJP- Heart.
vi ) In 2011 I was awarded the EEP’s section of the APS Honor award in which “I was recognized as
world-renowned for my work in elucidating the mechanisms associated with baroreflex control of
blood pressure during exercise”.

5. Complete List of Published Work in PubMed:
http://www.ncbi.nlm.nih.gov/pubmed/?term=raven+pb
D. Research Support
i ) Research Support Available
Ph.D. Graduate student Research-Gilbert Moralez, M.S
Institutional Bridge funding UNTHSC-RI6100 - $5,000, AY 2015
Title-“Role of reactive Oxygen Species in Exercise Intensity related increases in Arterial
Baroreflex Resetting”
ii ) Faculty Bridge Funding UNTHSC-RI6128 $44, 500, AY 2015
P.I. - P. B. Raven, Ph.D.
Title-“Exercise Induced Hypertension in Humans: Pathophysiological
Mechanisms”
Pending support
NHLBI (P.B. Raven, PI)-HL119442-02 10/01/15-TC $1,450,000
Title: “Exercise Induced Hypertension in Humans: Pathophysiological-Mechanisms” (Revised
proposal)
The project proposes to study whether centrally (within the brain) produced reactive oxygen species (ROS) are
the signaling molecules involved in arterial baroreflex resetting during progressive increases in exercise
intensity.
In addition, the study investigates whether patients with exercise induced hypertension (EIHt) is a result of an
exacerbated production of central ROS.
Completed Research Support
NHLBI (P. B. Raven, PI)-R-21 HL106431—01A1 07/15/11-09/30/13 plus ongoing NC
extension
Title-“The role of reactive oxygen species in intermittent hypoxia induced sympathoexcitation”
The project proposes to study whether the intermittent hypoxia associated with obstructive sleep apnea (OSA)
resulting in chronic sympathoexcitation can be blocked with the adjunctive use of free radical scavengers, such
as, N-Acetyl Cysteine or Vitamin C.
NHLBI (D. Keller, PI)-HL096103-01 04/01/09-03/31/12
Role on Project (Consultant)
Title-“Arterial Baroreflex function in African Americans at Rest and During Exercise”
This project proposes to study the effect of chronic physical activity on the cerebral hemodynamic regulation.
NHLBI (P. B. Raven, PI)-HL45547 07/01/96-06/30/07
Arterial Baroreflex Control of Blood Pressure (Exercise)
During the 12 years of funding this project identified the physiological mechanisms involved in arterial
baroreflex resetting during dynamic exercise and resulted in 73 peer reviewed publications, 4 book chapters
and the graduation of 7 Ph. D.s and 1 D.O./Ph.D.
Sponsor’s/Co-Sponsor’s Previous Fellows/Trainees
In the 37 years of Dr Raven’s tenure at UNTHSC he has mentored 18 MS degree graduates, 18 PhD
graduates, 2 of whom were dual degree DO/PhD graduates, and 9 post-doctoral fellows. One of the Post-
Doctoral Fellows, Shigehiko Ogoh worked with Dr Raven for 10 years and achieved Associate Research
Professor at UNTHSC before being enticed back to Japan to accept a Professorship at Toya University in
Tokyo.