High-grade colon cancer is associated with worse outcomes compared to low-grade disease, according to a study of over 900 colon cancer patients. The study found that high-grade colon cancer doubled the risk of lymph node and distant metastasis compared to low-grade disease. Patients with high-grade colon cancer also had double the risk of colon cancer-related mortality, even after accounting for disease stage. High tumor grade was identified as an independent factor that significantly influences colon cancer outcomes and mortality.