Keeping Pace With Immunotherapy Advances in Bladder Cancer: Tools for Winning the Race and Optimizing Patient Outcomes
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Arjun Balar, MD, and Petros Grivas, MD, PhD, discuss bladder cancer management in this CME activity titled "Keeping Pace With Immunotherapy Advances in Bladder Cancer: Tools for Winning the Race and Optimizing Patient Outcomes." For the full presentation, downloadable practice aids, monograph, complete CME information, and to apply for credit, please visit us at http://bit.ly/2GpacAq. CME credit will be available until December 30, 2019.
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Chair and Presenters, Yelena Y. Janjigian*, MD, Shubham Pant, MD, and John Strickler, MD, discuss HER2+ GI malignancies in this CME/MOC/NCPD/AAPA/IPCE activity titled “Precision Tactics in HER2-Positive GI Malignancies: Capitalizing on HER2-Targeted Regimens to Improve Outcomes for Gastric/GEJ Cancers, CRC, and BTC.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at https://bit.ly/49K4Qcb. CME/MOC/NCPD/AAPA/IPCE credit will be available until June 30, 2025.Anticoagulation Therapy in NVAF: A Quality Improvement Initiative
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Chair Kun "Kevin" Xiang, MD, PhD, discusses atrial fibrillation in this CME/MOC/NCPD/CPE activity titled “Anticoagulation Therapy in NVAF: A Quality Improvement Initiative.” For the full presentation, downloadable Practice Aids, monograph, and complete CME/MOC/NCPD/CPE information, and to apply for credit, please visit us at https://bit.ly/2UoPplb. CME/MOC/NCPD/CPE credit will be available until June 12, 2025.Supporting Patient-Centered Care in Generalized Pustular Psoriasis: Communica...
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Milan J. Anadkat, MD, and Dale V. Reisner discuss generalized pustular psoriasis in this CME activity titled "Supporting Patient-Centered Care in Generalized Pustular Psoriasis: Communications Strategies to Improve Shared Decision-Making." For the full presentation, please visit us at www.peervoice.com/HUM870.Improving Outcomes for Pediatric Patients With Uncontrolled Moderate-to-Sever...
Improving Outcomes for Pediatric Patients With Uncontrolled Moderate-to-Sever...PVI, PeerView Institute for Medical Education
Chair, William Anderson, MD, discusses severe asthma in this CME/MOC/NCPD/CPE/AAPA activity titled “Improving Outcomes for Pediatric Patients With Uncontrolled Moderate-to-Severe Asthma Using a Collaborative Approach: Recognition, Referral, and Management in the Era of Targeted Treatment Options.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/NCPD/CPE/AAPA information, and to apply for credit, please visit us at https://bit.ly/3IJWFAR. CME/MOC/NCPD/CPE/AAPA credit will be available until June 13, 2025.Safeguarding Patients With HR+, HER2-, High-Risk, Early Breast Cancer: A Prac...
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Chair and Presenters Professor Stephen Johnston, MA, PhD, Patrick Neven, MD, PhD, and Joyce O’Shaughnessy, MD, prepared useful Practice Aids pertaining to breast cancer for this CME/MOC/CPD/NCPD/CPE/AAPA activity titled “Safeguarding Patients With HR+, HER2-, High-Risk, Early Breast Cancer: A Practical Roadmap for CDK4/6 Inhibition in the Adjuvant Setting.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/CPD/NCPD/CPE/AAPA information, and to apply for credit, please visit us at https://bit.ly/49HZ5fH. CME/MOC/CPD/NCPD/CPE/AAPA credit will be available until June 21, 2025.Safeguarding Patients With HR+, HER2-, High-Risk, Early Breast Cancer: A Prac...
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Chair and Presenters Professor Stephen Johnston, MA, PhD, Patrick Neven, MD, PhD, and Joyce O’Shaughnessy, MD, discuss breast cancer in this CME/MOC/CPD/NCPD/CPE/AAPA activity titled “Safeguarding Patients With HR+, HER2-, High-Risk, Early Breast Cancer: A Practical Roadmap for CDK4/6 Inhibition in the Adjuvant Setting.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/CPD/NCPD/CPE/AAPA information, and to apply for credit, please visit us at https://bit.ly/49HZ5fH. CME/MOC/CPD/NCPD/CPE/AAPA credit will be available until June 21, 2025.Cases in the Community: Optimizing Treatment and Considering Weight Managemen...
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Chair, Javier Morales, MD, FACP, FACE, discusses Type 2 diabetes in this CME/CE/AAPA activity titled “Cases in the Community: Optimizing Treatment and Considering Weight Management as a Primary Goal in People with T2DM.” For the full presentation, downloadable Practice Aids, and complete CME/CE/AAPA information, and to apply for credit, please visit us at . CME/CE/AAPA credit will be available until June 11, 2025.Redefining Frontlines in CLL: Key Questions on the Role of CIT, BTKi Standard...
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Chair, Nicole Lamanna, MD, discusses chronic lymphocytic leukemia in this CME activity titled “Redefining Frontlines in CLL: Key Questions on the Role of CIT, BTKi Standards, and Innovative BTKi Combinations.” For the full presentation, downloadable Practice Aids, and complete CME information, and to apply for credit, please visit us at https://bit.ly/49Mazi3. CME credit will be available until June 11, 2025.Alzheimer’s Disease Case Conference: Gearing Up for the Expanding Role of Neu...
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Co-Chairs, Val J. Lowe, MD, and Cyrus A. Raji, MD, PhD, discuss Alzheimer’s disease in this CME/AAPA activity titled “Alzheimer’s Disease Case Conference: Gearing Up for the Expanding Role of Neuroradiology in Diagnosis and Treatment.” For the full presentation, downloadable Practice Aids, and complete CME/AAPA information, and to apply for credit, please visit us at https://bit.ly/3PvVY25. CME/AAPA credit will be available until June 28, 2025.Alzheimer’s Disease Case Conference: Gearing Up for the Expanding Role of Neu...
Alzheimer’s Disease Case Conference: Gearing Up for the Expanding Role of Neu...PVI, PeerView Institute for Medical Education
Co-Chairs, Val J. Lowe, MD, and Cyrus A. Raji, MD, PhD, prepared useful Practice Aids pertaining to Alzheimer’s disease for this CME/AAPA activity titled “Alzheimer’s Disease Case Conference: Gearing Up for the Expanding Role of Neuroradiology in Diagnosis and Treatment.” For the full presentation, downloadable Practice Aids, and complete CME/AAPA information, and to apply for credit, please visit us at https://bit.ly/3PvVY25. CME/AAPA credit will be available until June 28, 2025.Adapting HIV Treatment for People With Substance Use Disorder
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Chair, Monica Gandhi, MD, MPH, prepared useful Practice Aids pertaining to HIV for this CME/MOC/CE/AAPA activity titled “Adapting HIV Treatment for People With Substance Use Disorder.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/CE/AAPA information, and to apply for credit, please visit us at https://bit.ly/49hgPxT. CME/MOC/CE/AAPA credit will be available until June 4, 2025.Adapting HIV Treatment for People With Substance Use Disorder
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Chair, Monica Gandhi, MD, MPH, discusses HIV in this CME/MOC/CE/AAPA activity titled “Adapting HIV Treatment for People With Substance Use Disorder.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/CE/AAPA information, and to apply for credit, please visit us at https://bit.ly/49hgPxT. CME/MOC/CE/AAPA credit will be available until June 4, 2025.Aligning Clinical Practice With Emerging Evidence: Navigating the Rapidly Evo...
Aligning Clinical Practice With Emerging Evidence: Navigating the Rapidly Evo...PVI, PeerView Institute for Medical Education
Chair, Carla M. Nester, MD, MSA, FASN, discusses glomerular kidney disease in this CME activity titled “Aligning Clinical Practice With Emerging Evidence: Navigating the Rapidly Evolving Landscape of Glomerular Kidney Disease Management.” For the full presentation, downloadable Practice Aids, and complete CME information, and to apply for credit, please visit us at https://bit.ly/3wJPTs1. CME credit will be available until June 4, 2025.Experts vs AI: Who Is Better at Monitoring and Treating MASLD and MASH?
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Chair and Presenter Rohit Loomba, MD, MHSc, and Alina M. Allen, MD, MS, discuss metabolic dysfunction–associated steatohepatitis in this CME activity titled “Experts vs AI: Who Is Better at Monitoring and Treating MASLD and MASH?.” For the full presentation, downloadable Practice Aids, and complete CME information, and to apply for credit, please visit us at https://bit.ly/3O53xMy. CME credit will be available until June 19, 2025.Five Steps for Integrating BCMA Bispecific Innovations: From Clinical Data to...
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Co-Chairs, Prof. Mohamad Mohty, MD, PhD, and Caitlin Costello, MD, discuss refractory multiple myeloma in this CME/CPD activity titled “Five Steps for Integrating BCMA Bispecific Innovations: From Clinical Data to Clinical Practice in RRMM.” For the full presentation, downloadable Practice Aids, and complete CME/CPD information, and to apply for credit, please visit us at https://bit.ly/3UFL0dt. CME/CPD credit will be available until 5 June 2025.Stories Behind the Science in Non-Cystic Fibrosis Bronchiectasis: Understandi...
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Co-Chairs, Doreen J. Addrizzo-Harris, MD, and Cedric "Jamie" Rutland, MD, discuss non-cystic fibrosis bronchiectasis in this CME/MOC/AAPA activity titled “Stories Behind the Science in Non-Cystic Fibrosis Bronchiectasis: Understanding Disease Burden, Diagnosing Early, and Looking Toward New Management Options.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/AAPA information, and to apply for credit, please visit us at https://bit.ly/3KlxjL9. CME/MOC/AAPA credit will be available until June 19, 2025.Establishing the Collaborative Benchmark for HCC Care: Critical Discussions B...
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Co-Chairs Riad Salem, MD, MBA, and Mark Yarchoan, MD, discuss liver cancer in this CME/MOC activity titled “Establishing the Collaborative Benchmark for HCC Care: Critical Discussions Between Interventional Radiologists and Oncologists to Maximize Therapeutic Benefit.” For the full presentation, downloadable Practice Aids, and complete CME/MOC information, and to apply for credit, please visit us at https://bit.ly/3IOQvQ6. CME/MOC credit will be available until June 14, 2025.Bridging the Gap to Improved Outcomes in Non-Cystic Fibrosis Bronchiectasis: ...
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Co-Chairs, Brett Elicker, MD, and David E. Griffith, MD, ATSF, ACCP, OFRSM, prepared useful Practice Aids pertaining to non-cystic fibrosis bronchiectasis for this CME/MOC activity titled “Bridging the Gap to Improved Outcomes in Non-Cystic Fibrosis Bronchiectasis: Ensuring Prompt Diagnosis Through Accurate Interpretation of CT Imaging.” For the full presentation, downloadable Practice Aids, and complete CME/MOC information, and to apply for credit, please visit us at https://bit.ly/48WUULu. CME/MOC credit will be available until June 4, 2025.More from PVI, PeerView Institute for Medical Education (20)
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Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
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Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
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