New drug raises hope for an hiv vaccine

1. New drug raises hope for an
HIV vaccine
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2. Contd..
Scientists have developed a novel drug candidate that may lead to a potent
and universally effective HIV vaccine. Researchers found that the new drug
candidate blocks every strain of HIV-1, HIV-2 and SIV (simian
immunodeficiency virus) that has been isolated from humans or rhesus
macaques, including the hardest-to-stop variants. It also protects against
muchhigher doses of virus than occur in most human transmission and does
so for at least eight months after injection.
“Our compound is the broadest and most potent entry inhibitor described so
far,“ said Michael Farzan, from the Florida campus of The Scripps Research
Institute (TSRI). When HIV infects a cell, it targets the CD4 lymphocyte, an
integral part of the body's immune system. HIV fuses with the cell and
inserts its own genetic material and transforms the host cell into a HIV
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3. Contd..
The new study builds on previous discoveries by
the Farzan laboratory , which show that a co-
receptor called CCR5 contains unusual
modifications in its critical HIVbinding region, and
that proteins based on this region can be used to
prevent infection.
Farzan and his team devel oped the new drug
candidate so that it binds to two sites on the
surface of the virus simultaneously , preventing
entry of HIV into the host cell.
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4. Contd..
“When antibodies try to mimic the receptor, they touch a lot of other
parts of the viral envelope that HIV can change with ease,“ said TSRI
Research Associate Matthew Gardner, the first author of the study with
Lisa M Kattenhorn of Harvard Medical School.
The team also leveraged preexisting technology in designing a delivery
vehicle an engineered adeno-associated virus, a small, relatively
innocuous virus that causes no disease. Once injected into muscle
tissue, like HIV itself, the vehicle turns those cells into “factories“ that
could produce enough of the new protective protein to last for years,
perhaps decades, Farzan said.
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