Atrial natriuretic peptide (ANP) is a protein hormone secreted by heart muscle cells that acts as a powerful vasodilator. It is involved in homeostatic control of body water, sodium, potassium and fat levels. ANP binds to specific receptors and its effects include reducing blood pressure by decreasing blood volume and cardiac output through increased sodium excretion and water diuresis, as well as increasing lipolysis. The overall effect of ANP is to counteract increases in blood pressure and volume caused by the renin-angiotensin system.

2. • Atrial natriuretic peptide (ANP), atrial
natriuretic factor (ANF), atrial
natriuretic hormone (ANH), or
atriopeptin.
• a protein (polypeptide) hormone
secreted by heart muscle cells.
• is a powerful vasodilator.
• It is involved in the homeostatic control
of body water, sodium, potassium and
fat (adipose tissue).
• ANP acts to reduce the water, sodium
and adipose loads on the circulatory
system, thereby reducing blood
pressure.

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9. • Inhibits maladaptive cardiac hypertrophy.
• Cardiac load reduction
• Fibrosis inhibition

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11. • ANP binds to a specific set of receptors - ANP
receptors.
• Receptor-agonist binding causes a reduction in
blood volume and therefore a reduction in cardiac
output and systemic blood pressure.
• Lipolysis is increased and renal sodium reabsorption
is decreased.
• The overall effect of ANP on the body is to counter
increases in blood pressure and volume caused by
the renin-angiotensin system.

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