1. Nicholas James Coltman – BSc Forensic Bioscience Hons (1st
Class)
MRes Molecular Mechanistic Toxicology (Pending)
Career profile
Moleculartoxicology researchstudentwithparticularinterestsin DrugDiscoveryToxicology andDMPK, the use of
‘omicsand systemsbiologytosupportthe drugdiscoveryprocess,and Molecular&GeneticToxicology.Industrial
researchexperience gainedfrom internationally-recognisedregulatorytoxicologyandDrugDiscoveryCROs
supportedbythe use of analytical chemistrytechniquesandthe developmentof bioanalytical methodologies,and
the developmentof ADMET/DMPKassays to supportthe drug discoveryprocess.
Areas of excellence as supported by academia and employment history:
Outstanding communicator: a demonstratedcapacitytocommunicate challenginginformation,resultsand
outcomesacrossdifferentreporting-matricesandaudiences,tovariouslevelsof senioritywith the abilitytoengage
and motivate people.
Solution-focussed:rehearsedinprojectplanning/mappingandquick-solutionworkaroundsinordertopragmatically
addressproblemswithatargetedapproachto customerandteam satisfaction.
Passionate and driven: provenbythe consistent-yieldof highqualityworkbothinacademiaandprofessional
settings,continual pro-activeseekingof newknowledge acquisitionandbothself andteam-progression
opportunities.
Flexible andadaptable:capable of both leadingand beingled,withthe abilitytobe stretchedacrossnon-native
disciplines,withthe capabilitytoengage incross-functional andcross-cultural collaborative teams.
Key achievementstodate:
 Enhancingthe capabilitiescurrentlyprovidedbythe DMPKgroup at Sygnature Discovery throughin vitro
toxicology andDMPK assays,for screeningNCE/NBEsinthe drugdiscoverypipeline
 Takingownershipof client-projectsthroughanalytical methoddevelopmentstages,beingheldaccountable
for the developmentof robust,validatedandadaptable analytical-ecotox’protocols,HarlanLaboratories
 Selectedfromalarge-cohortof youngprofessionalsacrossthe countryfroma talent-pool,torepresentthe
UK at the EuropeanYouthParliament,Strasbourg.
 Awardedthe Facultyof HealthandWellbeingAwardforLeadership,SheffieldHallamUniversity
 Successfully ledScout-cohortsthroughcompetitive ‘High-Adventure’charity events,Leicestershire Scouting
Primary appointments
Research Scientist- DMPK and Bioscience,Sygnature Discovery,Nottingham BioCity
February 2016 – Present
 Primaryaimsto lendtoxicological supporttothe DMPKteam bydevelopingabatteryof in vitro assayssuch
as to predictandassessdrug inducedliverinjuryandhepatotoxicity inNCEs
 Developmentof cell-basedassaysthatcanbe adaptedforHCS imagingviaImageXpress confocal microscopy
and IncuCyte live cell imagingsuchasCytotoxicity,PhospholipidosisandMitoTox
 Assaydevelopmentexperience withinDrugTransporter (BSEP,MRP2and OATP) and DMPK (UGT, Caco and
Cyp) assays,withLCMS-TQSand MS-Q-ToFendpointson Watersplatforms
 Experience of assaytrainingtoDMPKassociatesandassay developmenttosupportgrowingbusinessneeds
Analytical Chemist– methoddevelopmentandanalysis, Envigo(FormallyHarlan Laboratories), Shardlow
February 2015 – September2015
 Providingmethoddevelopmentandsupportwithinahigh-throughputCRO environmenttowardsGLP,UKAS
and MHRA regulationswhilstmaintainingHarlan’scommitmentstoanimal welfare
 Methoddevelopmentforpharma,bioandindustrial-chemistryclientsacrossmammalianandaquatic
matricesusingLCMS 3Q, LCMS, UV andGC platforms
 Exposure toa range of analystapplicationsincluding Analyst,EZ-Chrom,ChemStation andOpen Lab
Applicationsacross AgilentandSciex platforms
Home address:Maple House,36 ForestRise,KirbyMuxloe,Leicester,LE92HQ E: nic.coltman@me.com
Nationality:British M: 077 256 52758
UK drivinglicense:Full DOB: 15/10/91

2.  Validationof analytical methodologies,maintenance of analyticalequipmentandself-training
 Full conformitytoSOPguidelines,GLPregulationandregularself-updatesof trainingrecords
Previousappointments – (furtherinformationavailable uponrequest –noteall parttime workran alongsidemy
academicprofile)
 SeniorBar Tender– PivovarUK,SheffieldandYork Feb2012 – Feb2015
 Waiter,bar tender– Delia’s(DeliaSmithRestaurant),Norwich Oct 2010 – Jun2011
 Safetymanagementandcrowdstewarding –LeicesterTigersRFC Nov2007 – Sept2009
 Contract cateringandeventsassistant –A La Carte catering,Leicester Nov2007 – Sept2011
Education and Training
(MRes) Researchin MolecularMechanisticToxicology – UniversityofBirmingham, School of Biosciences
September2015 – September2016
Degree Pending–distinctiontodate (XenobiticADME,Molecular& GeneticToxicology and‘Omicssciences )
Projectsynopsis –Sygnature DrugDiscovery,Nottingham BioCity:Developmentandvalidationof aHepaticLiability
Panel of assaysfor the screeningof discoverycompounds,andthe investigationof drug-metabolites oncell toxicity
by use of IncuCyte ® live cell imagingandLCMS-ToFplatforms.
(BSc) ForensicBiosciences(Hons)- SheffieldHallamUniversity, FacultyofHealth and Wellbeing
September2011 – June 2014
1st
ClassClassification (Humangenetics,microbiology,DNA technology,Pharmacology&Toxicology)
ProjectSynopsis - Pharmacokineticinvestigationof the biogenicamine, synephrineasa performance enhancing
drug.A methoddevelopmentforitsquantificationindietarysupplementsandhumanurine samplesbyDAD-HPLC
and NMR methodologies.
Undergraduate Science Foundation,primary modulesin Chemistryand Mathematics – Universityof East Anglia
September2010 – June 2011
Upper secondclass(2:1) (Appliedmathematics,chemical-biologyandphysics)
A-Levels– GrobyCommunity College,Leicester
September2008 – June 2010
History,ChemistryandBiology
Professional qualification, courses and workshops
Leadership:
 CommonPurpose UK – leadershippotential,projectmanagement,effective PMskillsandpeoplemotivation
 SportsLeadersUK – ForeignLanguage LeadershipinFrenchatprimaryandsecondaryschool level
 Cityand Guilds - NVQlevel 2QualificationinCrowdManagementandSafety
 Leicestershire Scouting –BeaverScout Leader
 EuropeanYouthParliamentRepresentative–Led a teamovera week’sconference/hearing
Coursesand Conferences:
 Anachem/MettlerToledo –Pipette Practice,minimisingexperimentalerrorandassaydevelopment
 ChromAcademy –ELearningwithregardto Analytical Methoddevelopmentof MS methodologies
 Subscribedattendeetothe Institute of MicrobiologyandInfection(IMI),Birmingham
 LapworthMuseumof GeologyLecture Seriesaspartof a keeninterestinPaleobiology,Birmingham
 Scheduledattendee tothe DrugmetabolismGroupsummerconference seriesand ELRIG 2017
Professional memberships:
 ChromAcademymember 2014 - Present
 Drug MetabolismDiscussionGroup 2016 – Present
 BritishToxicologySociety 2016 - Present
Personal profile – an openand approachable,self-starterthatis capable of leadingandbeingled
 A strongworkingproficiencyinFrench

3.  Self-taughtpianistwithparticularinterestsinJazz,BluesandNew-agerepertoires
 Avidcyclistandrunnerlookingtowardsjoininganamateurclub
 An amateurgolferlookingtowards scoringhisfirstpar.
 Culinarygeniuswith averykeeninterestincraftbeerandhome brewing!