Poster presentation for Rowett-INRA Conference

1. Fish oil Omega-3 intake modulates
intestinal dysbiosis and lipid profile
in zebrafish fed a high-fat diet
a
AZTI, Parque Tecnológico de Bizkaia, Astondo Bidea, Building 609 E-48160 Derio, Bizkaia, Spain
narias@azti.es
b
Cic-Biogune, Parque Tecnológico de bizkaia, Building 801A, Derio, Bizkaia, Spain
c
Immunology, microbiology and parasitology department, faculty of science and technology,
Basque country University (EHU/UPV) Barrio Sarriena s/n, 48940, Leioa, Bizkaia, Spain
Diet plays an important role inducing changes in the structure
and metabolism of the intestinal microbial community.
The consumption of a high-fat diet (HFD) is associated with a
less abundant and diverse gut microbiome, body fat accumula-
tion and inflammation.
Western diets are usually rich in saturated fatty acids (SFA) and
Omega-6, and contrary deficient in Omega-3, which play an im-
portant and opposed role. Omega-6 induces inflammation,
whereas omega–3 has anti-inflammatory properties. Thus, the
consumption of omega-3 rich diet promote beneficial effects on
host health. However, microbial changes associated with omega-
Arias-Jayo, N.a
, Abecia, L.b
, Arranz, S.a
, Tueros, I.a
, Rodríguez, A., Alonso-Saez, L.a
, Ramírez-García, A.c
, Pardo, M.A.a
INTRODUCTION MATERIALS AND METHODS
RESULTS AND DISCUSSION
CONCLUSION
These results suggest, that omega-3 supplementation exerts a beneficial effect on intestinal microbial
dysbiosis and host’s lipid profile
Acknowledgments: to the Department of Environment, Territorial Planning, Agriculture and Fisheries of the Basque Country
Government for the scholarship
This research is part of Maromega project and is financed by the Bas-
que Government (ELKARTEK 2016 CALL)
The aim
Study the impact of a high-fat diet and the possible
beneficial effect of a commercial fish oil rich in
omega-3 on the intestinal microbiome and lipid
metabolism in zebrafish
Fishlipidprofile
Changes in microbial community
The HFD consumption was associated with the increased in saturated fatty acids (SFA) in HFD fed animals, which correlated with the
increase of pseudomonas. In contrast, omega-3 intake diminished SFA, increasing polyunsaturated fatty acids (PUFA), which correlat-
ed with a reduction in the relative abundance of Pseudomonas.