1. Increased lifespan of mclk1+/- mice.
Xingxing Liu, Ning Jiang et al. Genes Dev. 2005;19:2424-2434
Cold Spring Harbor Laboratory Press
Editor's Notes
Increased lifespan of mclk1+/- mice. Kaplan-Meier survival curves are shown with p values calculated by the Mantel-Haenszel log rank test. Green indicates the mclk1+/- mice and red the wild-type mice in all three panels. (A) Lifespan extension in the 129Sv/J genetic background. mclk1+/- mice (n = 10) lived, on average, 15% longer than their wild-type (n = 12) littermates (824.8 ± 103.8 vs. 720.2 ± 96.1 d; p = 0.00045). All animals were female. (B) Lifespan extension in the 129Sv/J × Balb/c background. mclk1+/- mice (n = 9) live, on average, 31% longer than their wild-type littermates (n = 5) (980.4 ± 105.9 vs. 749.8 ± 57.2 d; p = 0.00025). (C) Lifespan extension in the C57BL/6J background. There are both males and females in the C57BL/6J study, and both sexes behave similarly. Although the study in the C57BL/6J background is not finished, the available data show a median survival of 686 d for mclk1+/+ (n = 5) and of 821.5 d for mclk1+/- (n = 8), a difference that is already significant at p = 0.00345. Currently, the median lifespan of the males is 726 d for mclk1+/+ (n = 3) and 837 d for mclk1+/- (n = 5) (p = 0.026).
