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Beta adrenergic blockers
1. RAJEEV GANDI COLLEGE OF PHARMACY BHOPAL M.P
MEDICINAL CHEMISTRY -1ST
B.PHARMACY 4RTH SEM
UNIT-2ND
Submitted To Submitted By
Anuj sir Muni sahu
-:Beta adrenergic blockers:-
(1) Propranolol:- It is used for the treatment of
hypertension angina pectoris post cardial
infraction, hypertrophic ,cardiommyopathy ,
phrnocytochroma , migraine prophyllaxis and
emotional tremors.The major metabolites
reported after sigal oral dose is naphthoxylactic
acid which is form by series of various metabolic
reaction such as N-dealkylation , deamination and
oxidation.
2. Use- 1. For treatment of cardiac arrhythmias.
2. Treatment of hypertension .
(2) Metipranolol:- Metipranolol is an non
selective beta blocker used in eye drops to
treat glaucoma. It is rapidly metabolized into
deacetylmetipranolol.
3. Use- 1. For treatment of hypertension.
(3) Atanolol:- It is a selective beta blocker
which is used for the treatment of
hypertension and angina pectoris.
It has long duration of action and may be
administered in a single daily dose.
4. Use- 1. For the treatment of angina pectoris
and hypertension.
(4) Acebutolol:- Acebutolol is a selective beta
blocker. It is having antihypertensive
antianginal and antiarrhythmic activities.
Use- 1. For the treatment of hypertension.
(5) Betazolol:- Betazolol is a selective betal
receptor blocker used in the treatment of
hypertension and glaucoma. Being selective
for betal receptors, it typically has fewer
systemic side effects than non selective beta
blockers.
5. Use- 1. For treatment of glaucoma and
cardiac heart failure.
(6) Bisoprolol:- Bisoprolol medicine is most
commonly used for heart diseases. This
specifically includes high blood pressure,
chest pain from not enough blood flow to the
heart and heart failure. It is taken by mouth.
6. Use- 1. For the treatment of hypertension. 2.
Congestive heart failure.
(7) Esmolol:- It is rapid onset and short
duration of action which render it useful
during surgery after an operation or during
emergency situation for short term control of
heart rates.
Use- 1. To control tachycardia during surgery.
7. (8) Metoprolol:- It is a beta blocker which is
available as its tartrate salt and occurs as a
water soluble crystalline white solid. It is a
selective Beta1-blocker.
Use- 1. For the treatment of hypertension.
(9) Labetolol hydrochloride:- It is an example
of antihypertensive drug.
Use- 1. For the treatment of hypertension.
8. (10) Carvedilol:- Carvedilol is a beta blocker
used for trating mild severe congestive heart
failure , left ventricular dysfunction following
and for trating high blood pressure.
Use- 1. For treatment of prepheral
vasodilation. 2. Emergency hypertension.