Etiology of breast cancer

1. Etiology & Risk factors of
Breast Cancer
Dr. MohammedFathyBayomy
Lecturer of ClinicalOncology
ZagazigUniversity

2. Risk Factors

3. Risk Assessment

4. Risk Assessment (Cont.,)
Models can give very different results for the same patient

5. Risk Assessment (Cont.,)
Risk calculator based
on Gail model

6. Risk Assessment (Cont.,)
Risk calculator based
on Tyler-Cuzick model

7. Risk Assessment (Cont.,)
IBIS Risk Calculator

8. Known Risk Factors

9. Known Risk Factors (Cont.,)

10. Age

11. Race

12. Family history

13. Family history (Cont.,)
ROJoson's breast cancer risk assessment

14. Benign & Proliferative breast disease

15. Benign & Proliferative breast disease (Cont.,)

16. Benign & Proliferative breast disease (Cont.,)

17. Benign & Proliferative breast disease (Cont.,)

18. Hereditary Cancer (Genetic factors)
Mutations dramatically increase risk of developing cancer

19. Hereditary Cancer (Cont.,)
Penetrance

20. Hereditary Cancer (Cont.,)
Genetic mutation

21. Hereditary Cancer (Cont.,)

22. Hereditary Cancer (Cont.,)
Mutations & Cancer

23. Hereditary Cancer (Cont.,)

24. Hereditary Cancer (Cont.,)

25. BRCA-1 gene
Location of BRCA-1 gene
Structure of BRCA-1 protein

26. BRCA-1 gene (Cont.,)

27. Family Pedigree

28. Autosomal Inheritance

29. BRCA-1 gene (Cont.,)
DNA Repair Pathways

30. BRCA-1 gene (Cont.,)
Functions of BRCA1 protein

31. BRCA-1 gene (Cont.,)
BRCA1 mutations
Founder effect in Ashkenazi Jewish

32. BRCA-1 gene (Cont.,)
BRCA mutation penetrance

33. BRCA-1 gene (Cont.,)
Risk of cancer associated with BRCA mutation

34. BRCA-2 gene
Location of BRCA-2 gene
Structure of BRCA-2 protein

35. BRCA-2 gene (Cont.,)

36. BRCA-2 gene (Cont.,)
BRCA2 mutations
Founder effect in Ashkenazi Jewish

37. P53 gene & Li-Fraumeni Syndrome (LFS)
Location of P53 gene Structure of p53 protein

38. P53 gene (Cont.,)

39. P53 gene (Cont.,)

40. P53 gene (Cont.,)

41. P53 gene (Cont.,)

42. PTEN gene & Cowden Syndrome (CS)
Location of PTEN gene
Structure of PTEN gene

43. PTEN gene (Cont.,)

44. PTEN gene (Cont.,)

45. PTEN gene (Cont.,)
Multiple papules on the dorsal
surface of the tongue with a
cobblestone appearance
Facial trichilemmomas

46. ATM gene & Ataxia Telangiectasia (A-T)
Location of ATM gene
Structure of ATM protein

47. ATM gene (Cont.,)

48. ATM gene (Cont.,)

49. ATM gene (Cont.,)

50. CHEK-2 gene & Li-Fraumeni Like (LFL)
Location of CHEK-2 gene
Structure of chk2 protein

51. CHEK-2 gene (Cont.,)

52. CHEK-2 gene (Cont.,)

53. CHEK-2 gene (Cont.,)

54. STK 11 gene & Peutz-Jaeger’s Syndrome
Location of STK 11 gene
Structure of LKB1 protein

55. STK 11 gene (Cont.,)
STK 11 gene function

56. STK 11 gene (Cont.,)
STK 11 gene mutations

57. Personal history of breast cancer

58. Personal history of breast cancer (Cont.,)

59. Endogenous Estrogen Exposure

60. Endogenous Estrogen Exposure (Cont.,)

61. Endogenous Estrogen Exposure (Cont.,)

62. Endogenous Estrogen Exposure (Cont.,)

63. Exogenous Estrogen ± Progestin Use

64. Women Health Initiative (WHI) Study
Study Design

65. Women Health Initiative (WHI) study (Cont.,)
Results

66. Million Women Study
Results (Cont.,)

67. Million Women Study (Cont.,)
Results

68. Million Women Study (Cont.,)
Results (Cont.,)

69. Million Women Study (Cont.,)
Results

70. HABITS Study
Study Design

71. HABITS Study (Cont.,)
Results

72. Oral Contraceptive Pills (OCP)

73. Obesity

74. Obesity (Cont.,)

75. Obesity (Cont.,)

76. Obesity (Cont.,)

77. Diet

78. Physical Activity

79. Radiation Exposure

80. Radiation Exposure (Cont.,)