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Fe++
Fe++
Fe++
Intestine
Fe++
absorption 15-20 %
Heme iron is easily
absorbed as a whole
structure with high
bio-availability.
Non-heme iron
must be dissolved
before uptake.
Because of low
absorption reactive
free iron ions
remain in the gut.
Fe++
Fe++
Fe++
Fe++
Fe++
absorption 2-4 %
Intestine
Fe++
Iron	
  in	
  food	
   	
  	
  	
   	
  	
  	
  	
  Bone	
  marrow	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  Hemoglobin	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
   	
  	
  	
  	
  	
  	
  	
  	
  	
  Menstrua2on	
  
	
   	
   	
   	
   	
   	
   	
   	
   	
   	
   	
   	
   	
  	
  	
  	
  	
  	
  (other	
  bleedings)	
  
	
  	
  	
  	
  	
  	
  	
  Heme	
  iron	
  
	
   	
   	
  	
  	
  	
   	
   	
  	
  	
  	
  	
  	
  Serum	
  iron	
   	
   	
  	
  	
  	
  	
  	
  Hemolysis	
   	
   	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  Urine	
  
Non-­‐heme	
  iron	
  	
  
	
   	
   	
   	
   	
   	
   	
   	
   	
   	
   	
   	
   	
  	
  	
  	
  	
  	
  	
  Bile	
  (faeces)	
  
Free	
  iron	
  Fe++	
  	
   	
   	
   	
   	
   	
   	
   	
   	
   	
   	
  	
  	
  	
  	
  	
  Intes2ne	
  cells	
  
Faeces	
   	
   	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  All	
  cells	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  Cell	
  apoptosis	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  Excreted	
  cells	
  
	
   	
   	
   	
   	
   	
   	
   	
   	
   	
   	
   	
   	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  Sweat	
  
1	
  mg/day	

Iron metabolism in the body
INTAKE USAGE EXCRETION

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Uptake and metabolism

  • 1. Fe++ Fe++ Fe++ Intestine Fe++ absorption 15-20 % Heme iron is easily absorbed as a whole structure with high bio-availability. Non-heme iron must be dissolved before uptake. Because of low absorption reactive free iron ions remain in the gut. Fe++ Fe++ Fe++ Fe++ Fe++ absorption 2-4 % Intestine Fe++
  • 2. Iron  in  food                Bone  marrow                                  Hemoglobin                                        Menstrua2on                                      (other  bleedings)                Heme  iron                            Serum  iron                Hemolysis                            Urine   Non-­‐heme  iron                                          Bile  (faeces)   Free  iron  Fe++                                  Intes2ne  cells   Faeces                                        All  cells                                            Cell  apoptosis                                  Excreted  cells                                              Sweat   1  mg/day Iron metabolism in the body INTAKE USAGE EXCRETION