definition: It a type of a tablet that dissolve, sprays or film that is used by placing the drug under the tongue, and it is absorbed and dissolved into the blood stream through the mucous membrane. it is considered to be absorbed very fast into the circulation, as it doesn’t pass through the digestive system and the area under the tongue is rich with tiny blood capillaries. Sublingual is used in such cases as :
- Patient that cannot swallow drugs
- Drugs that should be absorbed quickly into the circulation
- Drugs that the digestion would decrease there effect.
advantages & disadvantages
active ingredients
market production
conclusion: Overall, sublingual have a lot of advantages as it is very rapid and potent, the disadvantages is that it may interferes with food and drinking, not used with unconscious patient. There are many API of the sublingual tablets such as Buprenorphine HCL, Isosorbide dinitrate, and Hyoscyamine sulphate, etc . there are many international and national drugs used as sublingual such as saphris, abstral, isodril and nervidox, etc .
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sublingual tablet
1. Faculty of pharmacy
Pharmaceutics department
It a type of a tablet that dissolve, sprays or
film that is used by placing the drug under
the tongue, and it is absorbed and dissolved
into the blood stream through the mucous
membrane. it is considered to be absorbed
very fast into the circulation, as it doesn’t
pass through the digestive system and the
area under the tongue is rich with tiny blood
capillaries. Sublingual is used in such cases
as :
- Patient that cannot swallow drugs
- Drugs that should be absorbed quickly into
the circulation
- Drugs that the digestion would decrease
there effect. (Lowey, H., 1999)
- Buprenorphine HCL: treat the opioid
dependence.
- Isosorbide dinitrate: treat attack of angina.
- Hyoscyamine sulphate: antispasmodic or
anticholinergic to treat stomach problem like
cramps, bowel control problem and bladder.
- Ergotamine tartrate: treat migraine.
- Asenapine: treat antipsychotic like
schizophrenia and acute mania.
- Fentanyl citrate: analgesic opioid agonist.
- Orchard, timothy and sweet vernal:
immunotherapy to treat symptoms of grass
pollen allergic rhinitis
- Zolipidem tartrate: sedative and hypnotic.
Used to treat sleep problem.
- Nitroglycerin: vasodilator.
- Ondansetron: block action of chemical in the
body trigger like nausea and vomiting that
may cause by medicine to treat cancer
- Polyethylene glycol 3350: polymer of film
coat-tablet. (Pather, 2001)
Made By : Marina Eshak 170767
Merna Rames 171291
Marina Awny 173713
Miray Emad 170091
Menrva Father Moisis 170429
Lab group C1
Under supervision of: Prof. Reham Amer
2. Advantages
• A relatively rapid onset of action can be achieved
compared to the oral route, and the formulation
can be removed if therapy is required to be
discontinued.
• Liver is bypassed and also drug is protected from
degradation due to pH and digestive enzymes of
the middle gastrointestinal tract
• Improved patient compliance due to the
elimination of associated pain with injections;
administration of drugs in unconscious or
incapacitated patients; convenience of
administration as compared to injections or oral
medications.
• Low dosage gives high efficacy as hepatic first
pass metabolism is avoided & reduces side effects.
• The large contact surface of the oral cavity
contributes to rapid and extensive drug absorption.
• Due to rapidity in action these sublingual dosage
forms are widely used in emergency conditions e.g.
asthma. (Fusari,2005)
• Rapid absorption and higher blood levels due to
high vascularization of the region and therefore
particularly useful for administration of anti-angina
drugs.
• They also present the advantage of providing fast
dissolution or disintegration in the oral cavity,
without the need for water or chewing.
Disadvantages
• Since sublingual administration of
drugs interferes with eating, drinking,
and talking, this route is
generally considered
unsuitable for prolonged
administration. (Pawar et al, 2018)
• Although this site is not well suited to
sustained‐delivery systems.
• Sublingual medication
cannotbe used when
a patient is Un-cooperative or unconscious.
• The patient should not smoke while taking
sublingual medication, because smoking causes
vasoconstriction of the blood vessels. This will
decrease the absorption of the medication.
Market Products
Saphris used
for acute
mania &
schizophrenia
Used for
management of
breakthrough
pain adult
cancer patient
Supplement for
improve health
Acute relief of angina
(Shim et al., 2013)
Important for
normal blood
conclusion
Overall, sublingual have a lot of advantages as it is
very rapid and potent, the disadvantages is that it
may interferes with food and drinking, not used with
unconscious patient. There are many API of the
sublingual tablets such as Buprenorphine HCL,
Isosorbide dinitrate, and Hyoscyamine sulphate, etc .
there are many international and national drugs
used as sublingual such as saphris, abstral, isodril
and nervidox, etc .
References
- Shim, B., Choi, Y., Cheon, I. and Song, M. (2013). Sublingual
Delivery of Vaccines. Immune Network, 13(3), p.81.
- Pawar, P., Ghorpade, H. and Kokane, B. (2018). Sublingual
route for systemic drug delivery. Journal of Drug Delivery and
Therapeutics, 8(6-s), pp.340-343.
- Fusari, S.A., 1973. Nitroglycerin sublingual tablets: sublingual
over oral. Journal of pharmaceutical sciences, 62(12), pp.2012
- Lowey, H., 1999. Timed release sublingual medications. U.S.
Patent 3,428,728.
Pather, S.I., Khankari, R., Robinson, and Hontz, J., Cima Labs
Inc, 2001. Sublingual buccal tablets. U.S. Patent 6,200,604.
as immunotherapy
tablet