FAST DISSOLVING ORAL FILMS PRESENTED BY B.JAGADEESH BABU M.Pharm
OVER VIEW INTRODUCTION SPECIAL FEATURES GENERAL PROPERTIES FORMULATION METHOD OF PREPARATION EVALUATION TESTS ADVANTAGES & DISADVANTAGES CONCLUSION
INTRODUCTION These are the drug delivery systems which fastly disintegrate in mouth with H2O. It was first developed in 1970’s alternative to tablets & capsules. It consists of very thin oral strip which is placed on tongue & upon hydration it fastly releases drug into oral cavity.
Thin elegant film Available in various sizes & shapes Unobstrusive Excellent mucoadhesion Rapid release
GENERAL PROPERTIES Thickness ranges from 1-10mm & it’s surface area is 1-20 cm². Its low dry tack allows for ease of handling & application. Its rapid hydration rate facilitates fast softening & absorption. 2mm thickness of film will take 5-10sec to start its disintegration.
FORMULATION DRUG WATER SOLUBLE POLYMER SUPER DISINTEGRANTS PLASTISIZER SURFACTANTS FLAVOURS COLOURS SWEETENING AGENTS SALIVA STIMIULATING AGENTS
SOLVENT CASTING* SEMI-SOLID CASTING HOT MELT EXTRUSION SOLID DISPERSION EXTRUSION ROLLING METHOD
Convenient dosing No water needed No risk of chocking Taste masking Enhanced stability First pass metabolism can be avoided
Easily fragile & brittle. Special package for protection during storage & transportation.
These are having several advantages over conventional dosage forms like ODT, TABLETS, CAPSULES ,IV etc., so they are of great importance during the emergency cases such as allergic reations & asthamatic attacks.