This document discusses various neoplastic lesions that can occur in lymph nodes, including lymphomas such as angioimmunoblastic T-cell lymphoma and anaplastic large cell lymphoma, tumors of the accessory immune system like follicular dendritic cell tumor and interdigitating dendritic cell tumor, vascular tumors like Kaposi's sarcoma, spindle cell tumors, and metastatic tumors from other organs. It provides descriptions of the histopathological features of these different types of lymph node tumors.

1. NEOPLASTIC LESIONS
OF LYMPH NODE
Dr. Meghana P

2. • Lymphoma
• Tumors of accessory immune system
• Vascular tumors
• Spindle cell tumors
• Metastatic tumors

3. MATURE T- AND NK- CELL NEOPLASMS

4. ANGIOIMMUNOBLASTIC T-CELL
LYMPHOMA (AITL)
• Angioimmunoblastic lymphadenopathy
• Immunoblastic lymphadenopathy
• Lymphogranulomatosis X

5. ANGIOIMMUNOBLASTIC T-CELL
LYMPHOMA

6. ANGIOIMMUNOBLASTIC T-CELL
LYMPHOMA
BURNT – OUT GERMINAL CENTERS

7. ANGIOIMMUNOBLASTIC T-CELL
LYMPHOMA

8. ANGIOIMMUNOBLASTIC T-CELL
LYMPHOMA

9. ANGIOIMMUNOBLASTIC T-CELL
LYMPHOMA

10. ANAPLASTIC LARGE CELL LYMPHOMA
(ALCL)

11. ANAPLASTIC LARGE CELL LYMPHOMA

12. ANAPLASTIC LARGE CELL LYMPHOMA

13. ANAPLASTIC LARGE CELL LYMPHOMA

14. ALCL - LYMPHOHISTIOCYTIC VARIANT

15. ALCL - SMALL CELL VARIANT

16. ANAPLASTIC LARGE CELL LYMPHOMA -
CYTOLOGY

17. ANAPLASTIC LARGE CELL LYMPHOMA -
CYTOLOGY

18. PERIPHERAL T-CELL LYMPHOMA, NOS
(PTCL, NOS)

19. PERIPHERAL T-CELL LYMPHOMA, NOS

20. PERIPHERAL T-CELL LYMPHOMA, NOS

21. PERIPHERAL T-CELL LYMPHOMA, NOS

22. PERIPHERAL T-CELL LYMPHOMA, NOS

23. PTCL, NOS - LYMPHOEPITHELIOID
VARIANT

24. PTCL, NOS - LYMPHOEPITHELIOID
VARIANT

25. PTCL, NOS - T-ZONE VARIANT

26. PERIPHERAL T-CELL LYMPHOMA, NOS -
CYTOLOGY

27. TUMORS OF THE ACCESSORY
IMMUNE SYSTEM

28. FOLLICULAR DENDRITIC CELL
TUMOR
• Follicular dendritic cell sarcoma
• Dendritic reticulum cell sarcoma

29. FOLLICULAR DENDRITIC CELL
TUMOR

30. FOLLICULAR DENDRITIC CELL
TUMOR
VAGUE NODULES

31. FOLLICULAR DENDRITIC CELL
TUMOR
VAGUE NODULE

32. FOLLICULAR DENDRITIC CELL
TUMOR
FASCICLES AND WHORLS

33. FOLLICULAR DENDRITIC CELL
TUMOR
STORIFORM OR PALISADING

34. FOLLICULAR DENDRITIC CELL
TUMOR

35. FOLLICULAR DENDRITIC CELL
TUMOR

36. FOLLICULAR DENDRITIC CELL
TUMOR – LOW GRADE

37. FOLLICULAR DENDRITIC CELL
SARCOMA – HIGH GRADE

38. FOLLICULAR DENDRITIC CELL TUMOR –
MORPHOLOGIC VARIABILITY
EOSINOPHILS

39. CASTLEMAN DISEASE LIKE
FOLLICULAR DENDRITIC CELL TUMOR –
MORPHOLOGIC VARIABILITY
a
b
c

40. WARTHIN FINKELDEY TYPE GIANT CELL
FOLLICULAR DENDRITIC CELL TUMOR –
MORPHOLOGIC VARIABILITY

41. INTERDIGITATING DENDRITIC
CELL TUMOR

42. INTERDIGITATING DENDRITIC
CELL TUMOR

43. INTERDIGITATING DENDRITIC
CELL TUMOR

44. INTERDIGITATING DENDRITIC
CELL TUMOR

45. INTERDIGITATING DENDRITIC
CELL TUMOR – LOW GRADE

46. INTERDIGITATING DENDRITIC
CELL SARCOMA – HIGH GRADE

47. LANGERHANS CELL HISTIOCYTOSIS

48. LANGERHANS CELL HISTIOCYTOSIS

49. LANGERHANS CELL HISTIOCYTOSIS

50. LANGERHANS CELL HISTIOCYTOSIS

51. LANGERHANS CELL HISTIOCYTOSIS -
CYTOLOGY

52. ERDHEIM-CHESTER DISEASE (ECD)

53. ERDHEIM-CHESTER DISEASE

54. ERDHEIM-CHESTER DISEASE

55. ERDHEIM-CHESTER DISEASE

56. ERDHEIM-CHESTER DISEASE -
CYTOLOGY

57. HISTIOCYTIC SARCOMA

58. HISTIOCYTIC SARCOMA

59. HISTIOCYTIC SARCOMA

60. VASCULAR TUMORS

61. KAPOSI SARCOMA
• Classic
• African (endemic)
• Childhood
• HIV associated
• Transplant associated

62. KAPOSI SARCOMA

63. KAPOSI SARCOMA

64. KAPOSI SARCOMA

65. KAPOSI SARCOMA

66. KAPOSI SARCOMA - CYTOLOGY

67. SPINDLE CELL TUMORS

68. HEMORRHAGIC SPINDLE-CELL TUMOR
WITH AMIANTHOID FIBERS

69. HEMORRHAGIC SPINDLE-CELL TUMOR
WITH AMIANTHOID FIBERS
SPINDLE CELLS HAEMORRHAGE

70. HEMORRHAGIC SPINDLE-CELL TUMOR
WITH AMIANTHOID FIBERS
AMIANTHOID FIBERS

71. MISCELLANEOUS TUMORS

72. SYSTEMIC MASTOCYTOSIS

73. MYELOID SARCOMA
CD33

74. MYELOID SARCOMA - CYTOLOGY

75. METASTATIC TUMORS

76. SQUAMOUS CELL CARCINOMA

77. SQUAMOUS CELL CARCINOMA

78. SQUAMOUS CELL CARCINOMA

79. SQUAMOUS CELL CARCINOMA

80. SQUAMOUS CELL CARCINOMA
CYSTIC CHANGE

81. SQUAMOUS CELL CARCINOMA -
CYTOLOGY

82. ADENOCARCINOMA

83. ADENOCARCINOMA

84. ADENOCARCINOMA

85. ADENOCARCINOMA

86. ADENOCARCINOMA - CYTOLOGY

87. SMALL CELL CARCINOMA

88. SMALL CELL CARCINOMA

89. SMALL CELL CARCINOMA -
CYTOLOGY

90. GERM CELL TUMOR

91. GERM CELL TUMOR

92. GERM CELL TUMOR - CYTOLOGY

93. METASTATIC MELANOMA

94. METASTATIC MELANOMA

95. METASTATIC MELANOMA

96. METASTATIC MELANOMA -
CYTOLOGY

98. REFERENCES
• Rosai and Ackerman’s Surgical Pathology : Rosai J, 11th
edition
• Pathological basis of disease : Robbins and Cotran, 9th
edition.
• WHO Classification of Tumours of Haematopoietic and
Lymphoid Tissue: 2017 revised edition.

99. THANK YOU