Breast cancer is a multi-step disease caused by genetic changes and influenced by mutagenic and nonmutagenic risk factors. It was originally theorized in the 1950s-1960s that breast cancer is a systemic disease and positive lymph nodes indicate a host-tumor relationship allowing metastasis. Current research analyzes gene expression profiles to better understand breast cancer development and identify gene signatures.

1. GENE EXPRESSION PROFILING IN
BREAST CANCER

2. Breast Cancer Theory: Fischer
(1954-1967)
Breast cancer is a Systemic Disease
Positive Lymph node is an Indicator of host-tumor
relationship that permits metastases.

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4. Breast Cancer
 a multi-step process
 genetic changes
 mutagenic/nonmutagenic
risk factors
 gene signatures

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