AQA forensic psychology revision for alevel paper 3.
SLIDE 25 - HOLT EXAMPLE : Holt - significant difference in positive behaviour compared to a non-token group.
For some reason that part wasn't included in the upload.
AQA forensic psychology revision for alevel paper 3.
SLIDE 25 - HOLT EXAMPLE : Holt - significant difference in positive behaviour compared to a non-token group.
For some reason that part wasn't included in the upload.
Crime Causation
Theories of Crime Causation
Name
Class
Date
Professor
Theories of Crime Causation
Crimes are illegal behaviors committed in society that violate the laws of the land. There have been many different theories proposed explaining what causes crime in society that include psychological theories that find crime is the result of disruptions in normal personality development while sociological theories blame the offenders environment for their criminal behavior. Biological theories find crime is the result of genetic, biochemical, or neurological deficiencies in the body and through research great strides have been made in identifying potential biological causes.
Biological Criminality
Biological theories focus on functions in the body that relate to criminal behavior. The first theory involving a potential biological case comes from the positivist school. The positivist viewpoints, from the perspective of Lombroso, Ferri and Garofalo, found that crime is related to heredity, physiological incapacity, or biogenic. Lombroso’s theory found that criminals were born and blamed physical features of the criminal on their deviant behavior. The physical abnormalities of the offender cause them to commit crimes, which are out of their control. Ferri and Garofalo had supported Lombroso in his theory that crime was the result of biological processes.
Despite these findings biological theories were quickly discredited and psychological and sociological causes for crime became more prevalent in society. Theorist looked at environmental factors such as poverty, or psychological factors, such as the abnormal development of the personality, or social learning. Biological theories became less prevalent in society due to the experiments of the Nazis’ scientists during War World II and it was not until the second half of the 20th Century that biological theories of crime began to once again emerge in society.
As biological theories of crime became more developed the focus became less on the physical characteristics of the offender and more on physical processes of the body. Research began to look at potential genetic connections to criminal behavior and conducted empirical studies on identical twins. The goal of these studies was to show that biological inheritance can affect the individual’s tendency towards criminality independently of or in conjunction with the social environment (Lynch, 2000). The research showed that when one twin commits a crime the likelihood of the other twin committing a crime is greater than if they were just regular siblings. The research on twin and the potential genetic makeup of the criminal was inconclusive but the research has shown a clear trend of an interrelationship between criminal behavior in the parent and the criminal behavior of their offspring.
The next significant biological theory of criminality finds neurological abnormalities are the cause of crim.
Unit VII Assignment IntroductionThe Nature vs- Nurture debate is a lon.docxkdennis3
Unit VII Assignment
Introduction
The Nature vs. Nurture debate is a long-standing controversy over whether human behavior is primarily determined by genetics (Nature) or by environmental factors (Nurture). The proponents of the nature vs. nurture argument for serial killers would contend that these individuals are born with particular tendencies or traits that cause them to commit horrible deeds. Lack of empathy, impulsivity and a propensity for violent action are a few of these predispositions. The argument put out by the opponents of the idea is that serial killers have innate traits and features that predispose them to crime. This encompasses a lack of compassion, guilt, and fear of the repercussions. This argument is particularly pertinent when considering the actions of serial killers, as some specialists argue that they are predisposed to violence from birth. Others, on the other hand, contend that environmental variables, including a traumatic upbringing, can contribute to developing aggressive impulses. The arguments in favor of nature are the genetic similarities among serial killers and the fact that some serial killers have a family history of mental illness. They would also emphasize that some serial killers have a history of mental illness, which genetic causes may bring on. Additionally, proponents of the "nature" camp would contend that even if serial killers are exposed to certain environmental variables, like a lack of parental supervision or violent media, these elements do not sufficiently explain serial killer behavior. The opposite viewpoint asserts that some serial killers have a hereditary propensity for aggression and violence, which increases their likelihood of becoming serial murderers. According to the Con side, a person's surroundings and upbringing can influence their development and conduct, but they do not necessarily turn them into serial killers. However, it might also intensify already present inclinations or trigger the emergence of certain antisocial behaviors. Genetics or environment alone cannot explain a serial killer's motivation, but a combination of the two may be able to. Serial killers are distinct individuals, moulded by their remarkable experiences, circumstances, and mindsets beyond a few basic qualities.
The Literature Review
The contentious argument regarding the causes of serial killers' behavior—their nature or nurture—will be examined in this literature review. The numerous hypotheses underlying the emergence of serial killers will be examined, along with the arguments for and against each hypothesis. It will also consider how these theories might affect society and law enforcement. This review will also discuss how comprehending this controversy might improve crime prevention measures. Ultimately, this analysis will summarize the numerous hypotheses and viewpoints concerning the controversy over the nature versus nurture factors in serial killers.
A brief look at the histological persp.
Literature ReviewAshley AshleyColumbia Southern .docxpauline234567
Literature Review
Ashley Ashley
Columbia Southern University
ENG 1302, English Composition
10 December 2022
Understanding serial killers' motivations, development, and habits can be challenging because they are among the most dangerous and elusive criminals. Researchers have conducted numerous studies to examine the various traits connected to serial killers to understand them better. A focus will be placed on the psychological, sociological, and environmental aspects that lead to the development of a serial killer as this literature review explores the various hypotheses and findings about serial killers.
According to psychological theories, serial killers are motivated by deep-seated urges for dominance, control, and power. Psychoanalytic theories suggest that there may be an underlying desire for vengeance resulting from feelings of rejection and victimization. Other psychological theories link severe mental disorders like psychopathy or schizophrenia to serial murders. According to Davies (2022), not all abused children go on to commit several murders, and not all serial killers were raped as youngsters. According to the article, a person's genetic makeup, trauma, environment, and personality are some elements that contribute to serial killer behavior. However, dismissing the two's link as the result of pure coincidence is impossible. A person is more prone to act violently if they have a specific monoamine-oxidase-A gene variant and experience abuse as a child. Not every child predisposed to genetically motivated aggression grows up to be a criminal (Davies, 2022).
According to sociological ideas, conditions including social and economic hardship, poverty, and a lack of access to quality education and employment prospects can mould people into serial killers. According to these views, serial killers may be motivated by a need for dominance and control over their surroundings. According to Entail (2021), an individual's propensity for serial killing is influenced by genetic and environmental factors. Serial killers are exceptional because their personal experiences have affected their personalities and attitudes. Investigations into serial killers are further complicated because many lead normal lives and hide behind very commonplace lifestyles, making it more challenging to locate them. Professionals and the general public have a lot of curiosity, which calls for more study and rigorous analysis. Without a doubt, a person's predisposition to commit serial murder may rise due to a confluence of inherited features and environmental factors. Thus, environment, trauma, personality, and inheritance all work together to determine serial killer behavior (Entail, 2021).
Because a criminal's attitude is molded by both their genetic composition (nature) and their upbringing and history, Hernandez et al. (2015) contend that all criminals are judged using the same standards (nurture). Understanding the mind is a major focus in psychology, enabling .
Studying more about criminal behavior and also about how criminal activities affect people in the society. Criminology theorist Lombroso also explains how criminal genes are shared withini the family which means if there is a criminal in a family that means next generation can also be criminals.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Crime Causation
Theories of Crime Causation
Name
Class
Date
Professor
Theories of Crime Causation
Crimes are illegal behaviors committed in society that violate the laws of the land. There have been many different theories proposed explaining what causes crime in society that include psychological theories that find crime is the result of disruptions in normal personality development while sociological theories blame the offenders environment for their criminal behavior. Biological theories find crime is the result of genetic, biochemical, or neurological deficiencies in the body and through research great strides have been made in identifying potential biological causes.
Biological Criminality
Biological theories focus on functions in the body that relate to criminal behavior. The first theory involving a potential biological case comes from the positivist school. The positivist viewpoints, from the perspective of Lombroso, Ferri and Garofalo, found that crime is related to heredity, physiological incapacity, or biogenic. Lombroso’s theory found that criminals were born and blamed physical features of the criminal on their deviant behavior. The physical abnormalities of the offender cause them to commit crimes, which are out of their control. Ferri and Garofalo had supported Lombroso in his theory that crime was the result of biological processes.
Despite these findings biological theories were quickly discredited and psychological and sociological causes for crime became more prevalent in society. Theorist looked at environmental factors such as poverty, or psychological factors, such as the abnormal development of the personality, or social learning. Biological theories became less prevalent in society due to the experiments of the Nazis’ scientists during War World II and it was not until the second half of the 20th Century that biological theories of crime began to once again emerge in society.
As biological theories of crime became more developed the focus became less on the physical characteristics of the offender and more on physical processes of the body. Research began to look at potential genetic connections to criminal behavior and conducted empirical studies on identical twins. The goal of these studies was to show that biological inheritance can affect the individual’s tendency towards criminality independently of or in conjunction with the social environment (Lynch, 2000). The research showed that when one twin commits a crime the likelihood of the other twin committing a crime is greater than if they were just regular siblings. The research on twin and the potential genetic makeup of the criminal was inconclusive but the research has shown a clear trend of an interrelationship between criminal behavior in the parent and the criminal behavior of their offspring.
The next significant biological theory of criminality finds neurological abnormalities are the cause of crim.
Unit VII Assignment IntroductionThe Nature vs- Nurture debate is a lon.docxkdennis3
Unit VII Assignment
Introduction
The Nature vs. Nurture debate is a long-standing controversy over whether human behavior is primarily determined by genetics (Nature) or by environmental factors (Nurture). The proponents of the nature vs. nurture argument for serial killers would contend that these individuals are born with particular tendencies or traits that cause them to commit horrible deeds. Lack of empathy, impulsivity and a propensity for violent action are a few of these predispositions. The argument put out by the opponents of the idea is that serial killers have innate traits and features that predispose them to crime. This encompasses a lack of compassion, guilt, and fear of the repercussions. This argument is particularly pertinent when considering the actions of serial killers, as some specialists argue that they are predisposed to violence from birth. Others, on the other hand, contend that environmental variables, including a traumatic upbringing, can contribute to developing aggressive impulses. The arguments in favor of nature are the genetic similarities among serial killers and the fact that some serial killers have a family history of mental illness. They would also emphasize that some serial killers have a history of mental illness, which genetic causes may bring on. Additionally, proponents of the "nature" camp would contend that even if serial killers are exposed to certain environmental variables, like a lack of parental supervision or violent media, these elements do not sufficiently explain serial killer behavior. The opposite viewpoint asserts that some serial killers have a hereditary propensity for aggression and violence, which increases their likelihood of becoming serial murderers. According to the Con side, a person's surroundings and upbringing can influence their development and conduct, but they do not necessarily turn them into serial killers. However, it might also intensify already present inclinations or trigger the emergence of certain antisocial behaviors. Genetics or environment alone cannot explain a serial killer's motivation, but a combination of the two may be able to. Serial killers are distinct individuals, moulded by their remarkable experiences, circumstances, and mindsets beyond a few basic qualities.
The Literature Review
The contentious argument regarding the causes of serial killers' behavior—their nature or nurture—will be examined in this literature review. The numerous hypotheses underlying the emergence of serial killers will be examined, along with the arguments for and against each hypothesis. It will also consider how these theories might affect society and law enforcement. This review will also discuss how comprehending this controversy might improve crime prevention measures. Ultimately, this analysis will summarize the numerous hypotheses and viewpoints concerning the controversy over the nature versus nurture factors in serial killers.
A brief look at the histological persp.
Literature ReviewAshley AshleyColumbia Southern .docxpauline234567
Literature Review
Ashley Ashley
Columbia Southern University
ENG 1302, English Composition
10 December 2022
Understanding serial killers' motivations, development, and habits can be challenging because they are among the most dangerous and elusive criminals. Researchers have conducted numerous studies to examine the various traits connected to serial killers to understand them better. A focus will be placed on the psychological, sociological, and environmental aspects that lead to the development of a serial killer as this literature review explores the various hypotheses and findings about serial killers.
According to psychological theories, serial killers are motivated by deep-seated urges for dominance, control, and power. Psychoanalytic theories suggest that there may be an underlying desire for vengeance resulting from feelings of rejection and victimization. Other psychological theories link severe mental disorders like psychopathy or schizophrenia to serial murders. According to Davies (2022), not all abused children go on to commit several murders, and not all serial killers were raped as youngsters. According to the article, a person's genetic makeup, trauma, environment, and personality are some elements that contribute to serial killer behavior. However, dismissing the two's link as the result of pure coincidence is impossible. A person is more prone to act violently if they have a specific monoamine-oxidase-A gene variant and experience abuse as a child. Not every child predisposed to genetically motivated aggression grows up to be a criminal (Davies, 2022).
According to sociological ideas, conditions including social and economic hardship, poverty, and a lack of access to quality education and employment prospects can mould people into serial killers. According to these views, serial killers may be motivated by a need for dominance and control over their surroundings. According to Entail (2021), an individual's propensity for serial killing is influenced by genetic and environmental factors. Serial killers are exceptional because their personal experiences have affected their personalities and attitudes. Investigations into serial killers are further complicated because many lead normal lives and hide behind very commonplace lifestyles, making it more challenging to locate them. Professionals and the general public have a lot of curiosity, which calls for more study and rigorous analysis. Without a doubt, a person's predisposition to commit serial murder may rise due to a confluence of inherited features and environmental factors. Thus, environment, trauma, personality, and inheritance all work together to determine serial killer behavior (Entail, 2021).
Because a criminal's attitude is molded by both their genetic composition (nature) and their upbringing and history, Hernandez et al. (2015) contend that all criminals are judged using the same standards (nurture). Understanding the mind is a major focus in psychology, enabling .
Studying more about criminal behavior and also about how criminal activities affect people in the society. Criminology theorist Lombroso also explains how criminal genes are shared withini the family which means if there is a criminal in a family that means next generation can also be criminals.
Similar to Are Criminals Biologically Determined?? (14)
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
2. Introduction
● Centuries ago, doctors performed
lobotomies on criminals,
believing it would “cure” the
offenders as their wrongdoings
were caused by a brain mutation.
● That procedure is no longer
practiced since the nature versus
nurture debate was unveiled.
● While the MAOA gene does cause adulthood aggression, the cause of
criminal acts is a mix between nature and nurture because people
who have a perfect homelife still commit crimes and people with
horrible upbringings do not always resort to criminal activity.
3. Nature
● Psychophysiology
○ Study of the interrelationships between
mind and body
● Blunted Autonomic Functioning
○ Weak nervous system
○ Interferes with body reactions
○ Can lead to increased antisocial behavior
which is often a trait in criminals
4. Hypothesis
● Fearlessness Hypothesis
○ Individuals don't deter from criminal acts because they do not have the
appropriate mind and body responses to risky situations nor do they realize the
potential consequences.
● Sensation-seeking Hypothesis
○ The blunted state of being is uncomfortable so the individual tries to compensate
for the lack of emotion and reaction by engaging in inappropriate acts.
● Somatic marker Hypothesis
○ “Somatic markers” such as sweaty palms, reveal emotions and can change the
decision making process.
5. Nurture
● Abuse and trauma
○ How a child reacts to abuse determines what they’ll do with their trauma,
such as reacting with anger or trying to make the world a better place.
● Media
○ The media has made this topic more of a cultural issue rather than a scientific
one, also turning it into a larger issue than need be.
● Civilian study
○ In a conducted study, civilians stated they believe that society, politics and
life affects the way an individual grows and adjusts throughout life,
psychologically.
6. “Serial Killer Gene”
● Mental disorder
○ Most people that the so called “genetic marker” is a mental
disorder, after all there was a study that showed that a high
number of criminals with the most violent crimes had mental
disorders.
● Predisposition
○ There is a certain type of gene that only exist in abused
children, it is believed to predispose a person to criminal
behavior.
● MAOA
○ The common misunderstood “killer gene,” is actually just an
aggression gene. The higher the levels, the lower the
aggression. It's believed to be the “most common denominator
in a criminal’s mind.”
7. Infamous Killers
● Bobby Joe Long
○ Has an extra X chromosome, causes him to make excess estrogen.
● Israel Keyes
○ Loved violence and to torture anything with a heartbeat, a believed psychopathic trait.
● Michael Madison
○ Suffered constant abuse from his mother and her boyfriends. The lack of nurturing and
love in his childhood led him to create another world for himself where he could take
control.
● Ted Bundy
○ Often believed to be psychotic, which was found to be false, he actually suffered from
severe bipolar disorder and showed low levels of MAOA gene activity.
● Jeffrey Dahmer
○ Childhood trauma that led him to grow distrustful
8. Conclusion
● In conclusion, a mixture between nature and nurture causes an
individual to commit criminal acts.
● Still, this controversial topic remains unsettled. With so many factors
playing into a person’s development, it is difficult to find a true
reasoning behind criminality.
9. Sources
● “Biological Risks Factors for Involvement of Crime.” The Ministry of Justice. Mar. 2009,
https://www.beehive.govt.nz/sites/default/files/Biological%20Risk%20Factors.pdf. Accessed
24 Sept. 2021.
● “Do Serial Killers Have an Extra Chromosome?“ The University of Melbourne. 30 Sep. 2014,
https://blogs.unimelb.edu.au/sciencecommunication/2014/09/30/do-serial-killers-have-an-
extra-chromosome/. Accessed 23 Sept. 2021.
● Hernandez, Jose, et al. “Nature (MAOA) and Nurture in a Criminal.” UC Merced Undergraduate
Research Journal. 2015, https://escholarship.org/uc/item/5w51b7bg. 25 Sep. 2021.
● Jones, Dan. “What Makes a Criminal?” New Scientist, vol. 247, no. 3290, July 2020, pp. 42–45.
EBSCOhost, doi:10.1016/s0262-4079(20)31213-6.
● Ling, Shichun, et al. “Biological Explanations of Criminal Behavior.” Psychology, Crime & Law:
PC & L, vol. 25, no. 6, 2019, pp. 626-640. doi:10.1080/1068316X.2019.1572753.
● Locker, Melissa. “American Psychos: 10 Modern Serial Killers You’ve Never Heard of.” Rolling
Stone. 1 Aug. 2016, https://www.rollingstone.com/culture/culture-lists/american- psychos-10-
modern -serial-killers-youve-never-heard-of-102597/israel-keyes-103521/. Accessed 29 Oct.
2021.
● “What Influences Criminal Behavior?” Walden University, 2021, https://www.waldenu.edu/
online-bachelors-programs/bs-in-criminal-justice/resource/what-influences-criminal-behavior.
Accessed 23 Sept. 2021.