This document summarizes Instagram's experience with Python and Django. It discusses why Instagram chose Python and Django, how they have scaled their Python/Django stack to support billions of users, and their process for migrating to Python 3 while minimizing disruptions. Key points include Instagram leveraging tools to profile performance bottlenecks, moving critical components to C/C++, and taking a gradual approach to migrating services to Python 3 one endpoint at a time over several months.