This document lists 7 primary congenital heart defects, describes a meta-analysis of 13 studies using pulse oximetry screening on over 229,000 newborns to detect critical congenital heart defects, and found an overall sensitivity of 76.5%, specificity of 99.9%, and low false positive rate of 0.14% when screening was performed after 24 hours of birth.
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The Power of Pulse Oximetry to Identify Babies with Congenital Heart Defects: Robert Koppel
1. • 7 primary targets
• Hypoplastic left heart syndrome
• Pulmonary atresia (with intact septum)
• Tetralogy of Fallot
• Total anomalous pulmonary venous return
• Transposition of the great arteries
• Tricuspid atresia
• Truncus arteriosus
Pulse Oximetry Screening
for Critical Congenital Heart Defects
2.
3. • Meta-analysis of 13 eligible studies with data
for 229,421 newborn babies
– Overall sensitivity of pulse oximetry for detection
of critical congenital heart defects was 76.5%
(95% CI 67.7 – 83.5)
– Specificity was 99.9% (95% CI 99.7 – 99.9)
– False-positive rate of 0.14% (95% CI 0.06 – 0.33)
– Low false positive rate when pulse ox done after
24 hours from birth compared to before 24 hours
Thangaratinam, et al., 2012.
Reliability of Pulse Oximetry Screening for CCHD