A very interactive presentation on Pharmacological management of Leprosy which displays: Briefly about leprosy Classification of antileprotic drugs Briefly About each antileprotic drug Lepra reactions Related questions.

2. LEARNING OBJECTIVES:
• BRIEFLY ABOUT LEPROSY
• CLASSIFICATION OF ANTILEPROTIC DRUGS
• BRIEFLY ABOUT EACH ANTILEPROTIC DRUG
• LEPRA REACTIONS
• RELATED QUESTIONS

3. THE HANSEN'S DISEASE?
•LEPROSY IS ALSO KNOWN AS HANSEN'S DISEASE, AFTER THE SCIENTIST WHO
DISCOVERED M. LEPRAE IN 1873
•LEPROSY IS A CHRONIC INFECTIOUS DISEASE CAUSED BY MYCOBACTERIUM LEPRAE,
AN ACID-FAST, ROD-SHAPED BACILLUS (RESISTANCE TO DECOLORIZATION)
Gerhard Armauer Hansen

4. LEPROSY…!
•MAINLY AFFECTS THE SKIN, THE PERIPHERAL NERVES, MUCOSA OF THE UPPER
RESPIRATORY TRACT, AND THE EYES.
•CURABLE AND TREATMENT IN THE EARLY STAGES CAN PREVENT DISABILITY
•TRANSMITTED VIA DROPLETS, FROM THE NOSE AND MOUTH, DURING CLOSE AND
FREQUENT CONTACT

5. PATHOPHYSIOLOGY OF LEPROSY

6. CLINICAL FEATURES LEPROSY

7. [Ridley Dopling]

9. PRINCIPLES IN LEPROSY MANAGEMENT

10. GUESS WHAT?
•YOU WILL FIND IT IN MERCURY, EARTH, MARS AND
JUPITER, BUT NOT IN VENUS OR NEPTUNE. WHAT IS
IT?

11. ANTILEPROMATOUS THERPY

12. DAPSONE
MOA

13. DAPSONE ADE

14. DAPSONE (DOSAGE AND THERAPEUTIC USES)
•DOSAGE: 50-100 MG TABLETS; 100 MG DAILY
•THERAPEUTIC USES:
•LEPROSY
•TOXOPLASMOSIS
•PNEUMOCYSTIS JIROVECI PNEUMONIA
•DERMATOLOGICAL DISORDERS LIKE ACNE, BULLOUS SLE, PEMPHIGUS

15. SULFONE SYNDROME

16. CLOFAZIMINE

17. CLOFAZIMINE ADE

18. RIFAMPICIN
MOA

19. ETHIONAMIDE

20. OFLOXACIN

21. MINOCYCLINE

22. CLARITHROMYCIN

23. GUESS WHAT?
•WHICH LETTER IN THE ALPHABETS HAS THE MOST
WATER?

24. CLASSIFYING LEPROSY

25. MULTI DRUG THERAPY [MDT]

26. ALTERNATIVE REGIMEN

27. LEPRA REACTIONS
• TYPE 1 – REVERSAL REACTION – TYPE 4 HYPERSENSITIVITY REACTIONS
– DELAYED HYPERSENSITIVITY
• TYPE 2 – ERYTHEMA NODOSUM LEPROSUM (ENL) - TYPE 3
HYPERSENSITIVITY REACTIONS – IMMUNE COMPLEX MEDIATED

28. TYPE 1 LEPRA REACTION

29. TYPE 2 LEPRA REACTION
Jarish Herxheimer

30. TREATING LEPRA REACTIONS

31. AWARENESS PROGRAMMES FOR LEPROSY
Survey Education Treatment (SET) strategy

32. THEORY QUESTIONS
•DAPSONE
•LEPRA REACTIONS
•CLOFAZIMINE

33. MCQ’S ON ANTILEPROTIC DRUGS
Q. ALL OF THE FOLLOWING ARE FIRST LINE ANTILEPROTIC DRUGS EXCEPT:
1. DAPSONE
2. THIACETAZONE
3. CLOFAZIMINE
4. RIFAMPICIN

34. MCQ’S ON ANTILEPROTIC DRUGS
Q. MOST EFFECTIVE DRUG AGAINST LEPROSY:
1. DAPSONE
2. CLOFAZIMINE
3. PROTHINAMIDE
4. RIFAMPICIN

35. MCQ’S ON ANTILEPROTIC DRUGS
Q. ALL OF THE FOLLOWING ARE TRUE ABOUT ANTILEPROTIC DRUGS EXCEPT:
1. CLOFAZIMINE IS A DYE
2. DAPSONE CAUSES 5 WEEK DERMATITIS
3. RIFAMPICIN DECREASES DNA DEPENDENT RNA POLYMERASE
4. DAPSONE IS A BACTERICIDAL DRUG

36. MCQ’S ON ANTILEPROTIC DRUGS
Q. WHICH AMONG THE FOLLOWING IS THE DRUG OF CHOICE IN A LEPRA REACTION IN CASES OF LEPROSY
PATIENTS AS SHOWN IN THE PICTURE BELOW?
1. THALIDOMIDE
2. SYSTEMIC CORTICOSTEROIDS
3. ANTIHISTAMINE
4. CLOFAZIMINE

37. MCQ’S ON ANTILEPROTIC DRUGS
Q. A 31 YEAR OLD PATIENT WAS DIAGNOSED TO HAVE BORDERLINE LEPROSY AND WAS STARTED ON
MULTIBACILLARY MULTIDRUG THERAPY. SIX WEEKS LATER HE DEVELOPED PAIN IN THE NERVES WITH
REDNESS AND SWELLING OF THE LESION. THE MANAGEMENT OF THIS ILLNESS CAN INCLUDE ALL OF THE
FOLLOWING EXCEPT:
1. NSAIDS
2. SYSTEMIC CORTICOSTEROIDS
3. STOP ANTILEPROTIC DRUGS
4. REST TO THE AFFECTED LIMB