Neuroleptic malignant syndrome (NMS) is a life-threatening reaction to neuroleptic or antipsychotic medication characterized by high fever, confusion, rigid muscles, and changes in blood pressure and heart rate. Complications from NMS may involve damage to skeletal muscles, abnormal potassium levels, kidney failure, or seizures. Both typical and atypical antipsychotics can cause NMS, though the risk is generally higher with typical medications.

48. Neuroleptic malignant syndrome (NMS) is a life-
threatening reaction that can occur in response to
neuroleptic or antipsychotic medication.
 Symptoms include high fever, confusion, rigid
muscles, variable blood pressure, sweating, and
fast heart rate.
Complications may include
rhabdomyolysis(damaged skeletal muscle breaks
down rapidly), high blood potassium, kidney
failure, or seizures.
Any medications within the family of neuroleptics
can cause the condition, though typical
antipsychotics appear to have a higher risk than
atypicals(2nd gen.)