The document discusses variants in the GRIN2A and GRIN2B genes. It summarizes findings from studies that analyzed 247 cases with GRIN2A variants and 91 cases with GRIN2B variants. The clinical features and severity of phenotypes associated with variants in these genes and other GRIN genes are compared. The presentation concludes by proposing the creation of a single large shared database for GRIN variants that would be accessible to researchers.