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GRIN variants are associated with a large number of conditions, in particular seizures and developmental delay. The clinical characteristics and patient attributes for GRIN2A and GRIN2B
variants will be summarized. Information will be provided on patient phenotype, location of variant in the context or protein domains, and symptom severity. Efforts to stratify and categorize patients on the basis of symptoms, location of mutation in terms of protein domain and gene is necessary to
improve clinical care.