HPRC has learned a lot over the past few years: high quality plastics are available (primarily PP and HPDE) for reuse in the healthcare industry, there is passion among stakeholders to divert this material away from the landfills, and there is a need and an opportunity for economic value creation if we can scale-up efforts to captures these plastic resources. This presentation, from the 2016 ReFocus Conference, discusses the efforts underway to demonstrate economic viability, and shares insights gained from our work on the Chicago Regional pilot project. The question today is, "how do we scale up our efforts to really make a difference?" and this is exactly the question the Chicago project is working to answer.