HIV DR ASSESMENT.pptx

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Hawa Muweesi

How to evaluate drug resistance in a an HIV positive sample

Health & Medicine

• SAMPLE ID: GENO12 DR.01A
RT codons analyzed: 1-307 RT Subtype: C
RT RESISTANCE POLYMORPHISM
NRTI RESISTANCE
POLYMORPHISM NONE
NNRTI RESISTANCE
POLYMORPHISM NONE
OTHER RT POLYMORPHISMS
V35T, T39E, S48T, K122E, A158S, K173A, D177E,
T200A, I202V, E204K, Q207E, R211K, V245Q,
E248D, D250E, L260I, A272P, K277R, L282X, T286A,
E291D, I293V

Nucleoside RT Inhibitor Predicted Resistance Phenotype
Abbreviation Generic Name
3TC Lamivudine Susceptible
ABC Abacavir Susceptible
AZT/ZDV Zidovudine Susceptible
d4T Stavudine Susceptible
ddI Didanosine Susceptible
FTC Emtricitabine Susceptible
TDF/TFV* Tenofovir Susceptible

Non-Nucleoside RT Inhibitors Predicted Resistance Phenotype
Abbreviation Generic Name
DLV Delavirdine Susceptible
EFV Efavirenz Susceptible
ETV Entravirine Susceptible
NVP Nevirapine Susceptible

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