Prebiotics postbiotics probiotics

1. Prebiotics,Probiotics,andPostbiotics
VeterinariansPerspective
Haroon RashidChaudhry
To a veterinarystudentsandmedical studentstheseare veryenticingwords,wordsinvogue,discussion
for Passion.Iwill trytosum up the variouspointshighlightingthese terms.The Problemseemedtohave
originatedwiththe developmentof bread.Man thoughtof a trick to make bread.Yeastwas carefully
storedinmoistclothbundlesandeverydaythe wiveswouldinoculatetheirbreadwithyeastandbake it
to formbread.The unleavenedbreadwasgoingoutof fashioninRome andAsiawas still learningthis
method.Noharm wasdone a newthingwas adoptedthe menfounditverypalatable andflavorswere
devised.Itwasverynutritiousandmenwouldsweatitout,burnthe extracaloriesanditbecame a
healthyfood.Thencame the commercializationbreadfounditswayintoeverything.Menstopped
sweatingitout,the calorieswere notbeingburntaccordingly.The wheatflourandcornflourwasbeing
processedandrefinedtosmallestparticle the roughagesandbranwas extractedoutthe whole of the
worldwas runningafterprocessed,refinedflour.The essentialityof the roughage hadbeenforgotten
for guthealth.The medicine menwere tryingtofigure outwhathad gone wrongwithhumangut.They
startedfiquringoutthatgerms rather microbesthe like of Sacchromycescervsiae andLactobacillus
bulgaricuswere beneficial forguthealth.Theynameditprobiotics.Evereyone wasrunningafterafter
these bugs.Slowlyandsteadilythesetwopassedthe testof time andstartedbecominghousehold
name.frombeingsimple probioticstheymaturedintofoodcommonfooditem.Peoplestartedtakingit
as foodand startedforgettingtheirbenefitsandthattheywere the original Probiotics.
Commercializationfounditswayintomedicineandpharmaceuticalsstartedfocusingonyoughurtand
yeastas probiotics,butthe ideafloppedbecause everyone couldmake youghurtandyeastbakingwas
householdstuff itwasverydifficulttosell itinsmallerquantitiesforhigherprice.Theystartedtheir
focuson probioticswhichwouldwouldbe heattolerantlikethe bacteriawhichcouldwithstandacid
environmentof the stomachandcookingheattheyfoundspore formingbacteria,butyrate producing
Clostridium, since youghurtandyeastneededtobe replenisheddailyingutthese new found clostridial
specieswouldcolonize the gutfora longertime,since the youghurtandyeastwouldproduce ahostof
organicacids causingacidificationof gutandthenformationof sodiumsaltsof the saidacidsthese
clostridiumwouldespeciallymake acetates,butyratesinlargerquantitieswhichwouldbenefitthe gut
and nervoussystemof the man.But ithad flawsof itsownit wouldnottolerate antibiotictherapy,
where the medical scientistsfoundanotherspore formingbacteriawhichwouldbe able towithstand
antibioticsandtheytermeditmulti drugresistant(MDR) Bacillusclausai.Sofartheywere successfulbut
the combinationwasfoundtobe more useful if some nondigestible fiberwaspresentanditsimply
wontwork withrefinedsugars.Forthat manhad alreadybeenusingIspaghol,wheatbran,andoat fiber
but that hadlongbeenoustedoutof nutritionbybaking.The fiberswouldhelpthe bacteriain
colonizingthe gut,aidingut motilityandwouldbe digestiblebythe bacteria.These fiberswere coined
as Prebiotics.The scientistsfoundthatalgal fiberswere beneficial sotheystartedrunningafteritthus
the chemical mannanoligosaccharidesgainedhighestpriority,while wheatbran,gluten,cornglutenand
oat bran couldnot be soldforhigherprofitsandlowerquantitybecause otherwise the wholerefiningof
the flourswouldbe nullified.Butwe don’twantomake aware people we wanttomake moneysonew

2. prebioticshave tobe devisedandhighlightedsothattheycan be marketed.Astime flew the scientists
foundoutthat certainprobioticsandprebioticcombinationsdon’tworkveyeffectivelybecause the
organicacids producedwouldnotbe enough.Now we addingtoourmiserya new termcalled
Postbiotics,andthe medical scientistsare claimingthatthe prebioticandprobioticscantworkif
postbioticsare notformed,Postbioticsare those organicacidswhichare producedbythe probiotics
while theydigestthe prebiotics.Topof the listpostbioticisthe butyricacidwhichacidifiesthe small
intestine andconvertsintobutyrate.Ithasbeenfoundthatthisbutyrate isgood forgut health,gut
bacteriaand the general bodyconditionof the bodywithbeneficial effectsonimmune system, nervous
systemandwhat notsystem.Thisdoesnotmeanthat the formicacid, aceticacid andotherorganic
acidswouldbe useless,theyhave theirownrole.Ihave a thoughtweren’twe alreadyusingpickle,
sauerkrautandthe fermentedcabbage (usedbyKoreans) longbefore thisfinding,weren’twe rightlong
ago whydidwe astray. Nowwe have the new storyof postbiotics,soonwe willestablishthatthe newly
discoveredprebioticsare notas effectiveaswheatbran,oatbran,corn glutenor forthat matterother
grainglutens.Soagainback to square one.