sorting the antiviral drugs for hiv and their procedure for suppress hiv virus.

1. HIV Antiretroviral Drug Therapy
Immunology
Hamid afkhami

2. › The most significant advance in the medical
management of HIV infection has been the treatment
of patients with antiviral drugs, which can suppress
HIV replication to undetectable levels.
› The drugs are distributed into six distinct classes based
on their molecular mechanism and resistance profiles.
ANTIRETROVIRAL THERAPY

3. Classes of antiviral drugs
1. nucleoside-analog reverse transcriptase inhibitors
(NRTIs)
2. non–nucleoside reverse transcriptase inhibitors
(NNRTIs)
3. integrase inhibitors
4. protease inhibitors (PIs)
5. fusion inhibitors *
6. coreceptor antagonists**
ENTRY INHIBITORS

4. Nucleoside/Nucleotide
-analog reverse transcriptase inhibitors (NRTIs)
› Emtricitabine (2013)
› tenofovir disoproxil
fumarate (2001)
› didanosine (2000)
› zidovudine (1987)
Ph

6. non–nucleoside reverse transcriptase inhibitors
(NNRTIs)
› Rilpivirine (2011)
› Etravirine (2011)

7. › Elvitegravir (2014)
› dolutegravir (2013)
Integrase inhibitors
co

8. › Darunavir (2006)
› Tipranavir (2005)
› Atazanavir (2003)
Protease inhibitors (PIs)
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9. › Fusion inhibitors block HIV
from entering the CD4 cells
of the immune system by
attaching to gp41.
› Enfuvirtide (2003)
Fusion inhibitors

10. › Maraviroc works by attaching to
a protein on the surface of the
immune cells. The protein is
called the CCR5 co-receptor.
› Maraviroc (2007)
Coreceptor antagonists

11. › Pharmacokinetic enhancers are used in HIV treatment to
increase the effectiveness of an HIV medicine included in an HIV
regimen.(EX atazanavir or darunavir )
› When used with atazanavir or darunavir, cobicistat interferes
with the breakdown of the drugs in the body. In this way,
cobicistat increases the blood levels of atazanavir or darunavir,
making them more effective.
› cobicistat
Pharmacokinetic Enhancers

12. › Highly Active AntiRetroviral Therapy
› emtricitabine, rilpivirine, and tenofovir
alafenamide
› emtricitabine and tenofovir alafenamide
Combination HIV Medicines

13. › antibody 3BNC117
› enzyme
discoveries

14. › www.ncbi.nlm.nih.gov
› www.medscape.com
› www.aidsinfo.nih.gov
› www.Wikipedia.com
› Cellular & molecular Immunology
eight edition (Abul k.Abass)
› Google image
Source

15. Have a nice day