Polyphenolics is a division of Constellation Brands, Inc., the world’s largest premium wine company and owner of famous brands, such as Franciscan, Simi, and the legendary Robert Mondavi Winery. As our parent company strives for excellence in making premium wines, Polyphenolics strives for excellence in making premium grape seed extracts. As a division of Constellation Brands, Polyphenolics has access to an abundant supply of California wine grapes.

1. Why Polyphenolics__________________

2. About Polyphenolics
Founded in 1996, Polyphenolics is a science
driven organization dedicated to researching
and developing innovative products using grape
seed derived polyphenols to deliver specific,
documented health benefits.

3. Division of Constellation Brands
Polyphenolics is a division of Constellation Brands, Inc.,
the world’s largest premium wine company and owner
of famous brands, such as Franciscan, Simi, and the
legendary Robert Mondavi Winery. As our parent
company strives for excellence in making premium
wines, Polyphenolics strives for excellence in making
premium grape seed extracts.
As a division of Constellation Brands, Polyphenolics has
access to an abundant supply of California wine grapes.

4. All Grape Seed Extracts are not
created equal.

5. Quality
Polyphenolics goes beyond federally mandated traceability
requirements, documenting all aspects of growing, treating,
and processing the grapes. Through painstaking supply chain
documentation and laboratory testing, Polyphenolics can
substantiate freshness, identity, domestic origin, and
absence of chemical contaminants and genetic modification.
Polyphenolics controls the entire manufacturing process,
from the initial selection of grapes to the final extraction of
finished material that is MegaNatural® grape seed extracts.

6. • MegaNatural® grape seed
extracts are adulterant free.
They come from 100%
California grown grapes
traceable to the fields they
were grown in.
• The consistency of every
batch is verified through
specialized HPLC testing.
Consistent activity
guarantees consistent
results in your finished
product.
Why You
Should Not Use
or Consider
Less Expensive/
Inferior Quality
Grape Seed
Extract in Your
Product.

7. What Differentiates
MegaNatural® Grape Seed
Extracts From Others?
•Four US Patents Issued
•World-Wide Patents Pending
•Unique Composition
•Original Research
•Clinically Proven
•Condition-Specific
•100% California-Grown Grapes
•100% Pure Grape Seed Extract
•100% Water Soluble
•No Chemical Solvents
•Relentlessly Tested
•FDA No-Objection GRAS

8. Identifying a Need
The Stealth Killer
America’s HIGH
BLOOD PRESSURE
crisis is spinning out
of control. Learn
about it, treat it and
maybe save your life.
Time
December 6, 2004

9. Prevalence of high blood pressure in
adults age 20 and older, by age and sex.
Source: NCHS and NHLBI.
12.2
24.4
38.8
53.2
65.4 64.6
6.6
16.2
38.4
54.1
70.8
77.3
0
10
20
30
40
50
60
70
80
90
20-34 35-44 45-54 55-64 65-74 75+
PercentofPopulation
Men Women

10. • 31% of US population (132 Million)
• 39% of men and 23% of women
• Between the ages of 20-39 yr:
• 37.4% in African Americans
 32.2% in Whites
• 30.9% in Hispanics
• 9 out of 10 of these people will
develop hypertension by 65
Pre-Hypertensive people create
a large market

11. Major Breakthrough in the
Development of
MegaNatural®-BP through original
research

12. Original Research
Polyphenolics has invested heavily in original research
at both the laboratory and clinical levels. Original
research is important because multiple factors, from
the grape varietals chosen, to the time of harvest, and
the extraction technique, can influence the profile of
the finished product. The only way to know if a
particular extract has biological efficacy is to test the
specific composition of the extract.

13. Mechanism of Action Study
How does MegaNatural®-BP Work?
Research using animal models indicates that it
activates the enzyme nitric oxide synthase (eNOS) to
produce nitric oxide (NO). NO is a gaseous compound
that acts as a cellular messenger. When NO is present
in the inner lining of the blood vessels, known as the
endothelium, it causes the surrounding smooth muscle
to relax. This endothelium-dependent relaxation of the
blood vessels then supports healthy blood flow.*

14. MegaNatural®-BP
causes a relaxation
of the blood vessels
This is similar to that elicited by acetylcholine
– a known vasodilator.

15. Human Clinical Trial #1
MegaNatural®-BP was found to help maintain blood pressure
levels within the normal range.

16. Human Clinical Trial #2
MegaNatural®-BP was found to help maintain blood pressure
levels within the normal range.
GSE Placebo
Systolic
BP
Diastolic
BP
Systolic
BP
Diastolic
BP
Initial 134 ± 2 79 ± 2 133 ± 1.9 79 ± 2
Final 126 ± 2 74 ± 2 133 ± 2.3 81 ± 2
Difference -8 -5 0 +2
P 0.003 <0.05 NS NS
Power (α at
0.05)
0.86 0.50
N = 15 for both groups

17. Human Clinical Trial #3
MegaNatural®-BP was found to help maintain blood pressure
levels within the normal range in a beverage.
Results: Consumption of MegaNatural®-BP beverage for six weeks led to a significant
reduction in systolic BP compared to placebo beverage that returned to baseline after four
week discontinuation of GSE beverage. Similar findings were apparent for diastolic BP
showing 4.7% reduction in DBP that returned to baseline after discontinuation of GSE
beverage. Subjects with higher starting BP experienced greater BP reduction.

18. Publications
1. Sivaprakasapillai et.al., Effect of grape seed extract on blood pressure in
subjects with the metabolic syndrome. Journal of Metabolism Clinical and
Experimental, (2009) 58 (12), 1743-1746.
2. Edirisinghe et.al., Mechanism of the endothelium-dependent relaxation evoked
by a grape seed extract. Clinical Science (2008) 114, 331-337.
3. Robinson et.al., Effect of Grape Seed Extract in Subjects with Pre-Hypertension,
Recent Advances in Cardiovascular Disease (2007) 13th World Congress on
Heart Disease, 239-242.
4. Robinson et. al., Effect of Grape Seed Extract in Subjects with Pre-Hypertension.
Journal of Pharmacy and Nutrition Sciences(2012) 2, 155-159.

19. Normal Phase HPLC Chromatogram of MegaNatural®-BP
MegaNatural®-BP is Structurally Unique, providing 90-
95% total polyphenols
(as monomers, oligomers, and polymers).

20. GRAS Notification to FDA
Polyphenolics conducted a subchronic three month
oral toxicity study of MegaNatural® seed and skin
extracts and micronucleus assay
• FDA “No Objections”GRAS for use in food and
beverages (August 2003)
• GRAS Extension in 2007

21. 1/3 of Americans could benefit
from MegaNatural®-BP
• Nearly 1 in 3 adults has high blood pressure
• 71.8% of adults with high blood pressure are
aware of their condition
• 64.9% of people with high blood pressure do
not have it under control

22. Patents

23. Structure Function Claims
• MegaNatural®-BP is a unique form of grape seed
extract that has been clinically shown to help
maintain healthy blood pressure levels within the
normal range.
• MegaNatural®-BP, a unique form of grape seed
extract, is an antioxidant that helps support
endothelial function by maintaining healthy nitric
oxide levels that are within the normal range. This
helps support healthy vasodilation and blood flow.

24. “
”
“If a formulator begins with a branded
ingredient that has endured vigorous R&D
already, it could ultimately save time, and
give confidence because a company’s R&D
is backed by additional studies.” Anil
Shrikhande, President, Polyphenolics
NATURAL PRODUCTS INSIDER, JUNE 2014

25. Our Customers
Polyphenolics believes in forming close partnerships with
our customers and remains available to customer partners
during all phases of product development for technical
questions and support.
MegaNatural® grape seed extracts are now included in
formulations targeting heart health, sports nutrition, blood
pressure maintenance, blood sugar maintenance, and
various prevention lines for men and women from some of
the most successful supplement companies in the world.

26. www.polyphenolics.com

27. QUESTIONS?