GLAUCOMA IN PHARMACOTHERAPY

3. primary open angle
glaucoma
normal tension glaucoma
juvinile
Treatment:
lower IOP Drops, trabecular
laser,glaucoma surgery
secondary open
angle glaucoma
pigment dipersion
syndrome
pseudoexfoliation
uveitic others
primary closed
angle glaucoma
Treatment:
open drainagepathway
lens extraction,laser
peripheral iridectomy
secondary closed
angle glaucoma

8. DRUGS CLASSIFICATION
(A). Increased levelof aqueous
outflow
Trabecular outflow
1).Non - specific
adrenergic agonists
2).cholinomimetics (or)
parasympathomimetics
Uveo - scleral
outflow
prostaglandin analogues
(B). Decreased
level of aqueous
outflow
1). Beta blockers
2).Alpha 2 - agonists
3).carbonic anhydrase
inhibitors

9. (A). INCREASED LEVEL OF AQUEOUS OUTFLOW:
Aqueous
humour
formation
trabecular
outflow
stimulates
alpha-2

10. Contraction
of pupil
iris comes to
normal
position
outflow of
aqueous
humour
becomes
normal

11. increases outflow of aqueous humour
INCREASES UVEO-SCLERAL MESHWORK
widens the spaces between trabecular meshwork
decreases intraocularpressure
It secretes matrix metallo proteinase enzyme
decreases extracellularmatrix

12. Drugs (beta blockers)
stimulates beta cells on
ciliary muscles
decreases aqueous
humour production

13. :
decreases intraocular pressure
DECREASES AQUEOUS HUMOUR PRODUCTION
acts on alpha receptors
(which are present on ciliary epithelium)
Drugs : alpha 2- agonists

15. it decreases fluid secretion
DECREASES THE AQUEOUS HUMOUR OUTFLOW
decreases sodium ion (Na+) retention
decreases intraocular pressure (IOP)
CARBONIC ANHYDRASE INHIBITORS
inhibitsthe bicarbonateion (HCO3)