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April 2010
www.venturefund.novartis.com




             Corporate Venture Capital


                                         Florent Gros
AGENDA


Novartis Venture Funds
Venture Drivers
Exit Drivers
European specificities
Innovative and Successful

 A Decade of Success                    Novartis Venture Fund
 14 years as a leading corporate        portfolio:
 (independent) venture capital firm     ~70 private companies
 Strong returns driven by looking
 beyond to what is “strategic to the
                                        ~$750M USD Capital Base
 industry”
                                        ~$15-20M USD per
 NVF reputation viewed as progressive
                                        investment
 & forward thinking
                                        45+ portfolio company board
 Two capital choices – Venture Fund
                                        seats
 and Option Fund
                                        Experienced team (Cambridge
 Independent decision making
                                        and Basel)
NVF Investment Criteria
    Unmet need /                         Management
    Clinical Impact                      experience




                      Innovation
                      Patient Benefit
                      Superior Returns



    Novel proprietary science            Capital
    / understanding of                   efficiency
    mechanism
Typical Investment Process

 Screen ~1000 companies and proposals per year
 Of the screened companies <1% conclude with an investment
 Lead syndicates when appropriate
 Multi-stage due diligence process with investment decision
 vested in the Novartis VC team and reviewed by independent
 board
 New investments +/- 20% stake, diluted down to +/ - 15% in
 later rounds, typically with board seat
 Follow on investments dependent on operational performance
 and financial discipline
 NVF is a long-term partner and enabler in developing the
 company and finding profitable exit
Geographic Distribution of
companies
Venture Drivers
Evolution of Total Venture
                         $Bn
            15

            14
            13
            12

             7

             6

             5

             2

             1


                      06 07 08 09   06 07 08 09   06 07 08 09   06 07 08 09   06 07 08 09


                       Seed         1st Round      2nd          Later         Recap
                                                  Round         Stage
Q1 2009 vs.
Q1 2008               -80%           -37%         -54%          -60%          -38%
 Source: NVCA, Thomson Financial
VCs Consequences….
        Lower valuations, more down-rounds and pay-to-
        play

        More scrutiny / due diligence and longer approval
Text    process

        Increased capital reserves for follow-on
        investments

        Increased focus on M&A driven by lower valuations
        and more widespread “build vs. buy”
        considerations
Corporate VCs
                                                                                                  18%

                                                                                                  16%

                                                                                                  14%

                                                                                                  12%

                                                                                                  10%

                                                                                                  8%

                                                                                                  6%

                                                                                                  4%

                                                                                                  2%


                     1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009




         Healthcare Corporate VCs seem to be backed by stronger
         strategic motivations and management commitment (and
       probably cash flows) that ensure stability and continuity even
                               in a downturn
Source: NVCA, Thomson Financial. Kauffman Fellows
Exit Drivers
Pharma has cash for biotech assets




   Biotech / medtech lack cash (> 40% have more than a
   years’ worth cash - nearly 100 publicly-traded biotechs do
   not have enough cash to last 6 months)

Source: Evaluate
Pharma deals continue to increase




Source: PharmaVentures/Pharma deals
Exit top-performers
  Top performing biotechs have raised median pre-exit
  funding of $36m and exit at a value of $250m, generating a
  median ROI of 5.4; median performers have raised
  median pre-exit $66m and exit at $133m, generating an
  ROI of 1.7
  Top performers have typically been exclusively venture
  funded pre-exit; companies with only venture funding
  represent 85% of the top performers in contrast to 49% of
  the total exited
  Top performers have a focused portfolio at exit; top
  performers 3 development and launched candidates at exit
  while the median have almost twice as many

Source: BioCentury; Windhover; McKinsey analysis
Exit Drivers


  Out- and in-licensing ARE NOT major
  performance drivers; top performers have
  licensed at the same rate as the median –
  BUT reliance on early stage alliances does
  help to be attractive for VCs
  VCs are exclusively focused on exit,
  minimum 1.7x ROI



Source: BioCentury; Windhover; McKinsey analysis
European Specificities ?
Source: PharmaVenture
Source: Rothshilds
Funding Strategy

 VC activity has contracted
 Generalist VCs have moved away leaving a fewer
 specialist VC firms
 Venture arms of big pharma now essential players
 (new in 2010: Serono, Boehringer, Sanofi, Merieux etc.)
 Some government match-fund initiatives have
 emerged (UK Innovation Fund €150m, French Innobio
 €150 mio, Max Plack)
 Large European grants through the Innovation
 Medicines Initiatives (FP7, Eureka etc). Large local
 grants available in France, Belgium, Italy. Attractive
 tax credit in France (€1 credit for €3 invested)
Not yet out of the woods, but
situation is improving
Thank You!


                       Florent Gros
                 Managing Director
             Novartis Venture Funds

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Novartis Venture Fund: A Decade of Success in Corporate Venture Capital

  • 1. April 2010 www.venturefund.novartis.com Corporate Venture Capital Florent Gros
  • 2. AGENDA Novartis Venture Funds Venture Drivers Exit Drivers European specificities
  • 3. Innovative and Successful A Decade of Success Novartis Venture Fund 14 years as a leading corporate portfolio: (independent) venture capital firm ~70 private companies Strong returns driven by looking beyond to what is “strategic to the ~$750M USD Capital Base industry” ~$15-20M USD per NVF reputation viewed as progressive investment & forward thinking 45+ portfolio company board Two capital choices – Venture Fund seats and Option Fund Experienced team (Cambridge Independent decision making and Basel)
  • 4. NVF Investment Criteria Unmet need / Management Clinical Impact experience Innovation Patient Benefit Superior Returns Novel proprietary science Capital / understanding of efficiency mechanism
  • 5. Typical Investment Process Screen ~1000 companies and proposals per year Of the screened companies <1% conclude with an investment Lead syndicates when appropriate Multi-stage due diligence process with investment decision vested in the Novartis VC team and reviewed by independent board New investments +/- 20% stake, diluted down to +/ - 15% in later rounds, typically with board seat Follow on investments dependent on operational performance and financial discipline NVF is a long-term partner and enabler in developing the company and finding profitable exit
  • 8. Evolution of Total Venture $Bn 15 14 13 12 7 6 5 2 1 06 07 08 09 06 07 08 09 06 07 08 09 06 07 08 09 06 07 08 09 Seed 1st Round 2nd Later Recap Round Stage Q1 2009 vs. Q1 2008 -80% -37% -54% -60% -38% Source: NVCA, Thomson Financial
  • 9. VCs Consequences…. Lower valuations, more down-rounds and pay-to- play More scrutiny / due diligence and longer approval Text process Increased capital reserves for follow-on investments Increased focus on M&A driven by lower valuations and more widespread “build vs. buy” considerations
  • 10. Corporate VCs 18% 16% 14% 12% 10% 8% 6% 4% 2% 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 Healthcare Corporate VCs seem to be backed by stronger strategic motivations and management commitment (and probably cash flows) that ensure stability and continuity even in a downturn Source: NVCA, Thomson Financial. Kauffman Fellows
  • 12. Pharma has cash for biotech assets Biotech / medtech lack cash (> 40% have more than a years’ worth cash - nearly 100 publicly-traded biotechs do not have enough cash to last 6 months) Source: Evaluate
  • 13. Pharma deals continue to increase Source: PharmaVentures/Pharma deals
  • 14. Exit top-performers Top performing biotechs have raised median pre-exit funding of $36m and exit at a value of $250m, generating a median ROI of 5.4; median performers have raised median pre-exit $66m and exit at $133m, generating an ROI of 1.7 Top performers have typically been exclusively venture funded pre-exit; companies with only venture funding represent 85% of the top performers in contrast to 49% of the total exited Top performers have a focused portfolio at exit; top performers 3 development and launched candidates at exit while the median have almost twice as many Source: BioCentury; Windhover; McKinsey analysis
  • 15. Exit Drivers Out- and in-licensing ARE NOT major performance drivers; top performers have licensed at the same rate as the median – BUT reliance on early stage alliances does help to be attractive for VCs VCs are exclusively focused on exit, minimum 1.7x ROI Source: BioCentury; Windhover; McKinsey analysis
  • 19. Funding Strategy VC activity has contracted Generalist VCs have moved away leaving a fewer specialist VC firms Venture arms of big pharma now essential players (new in 2010: Serono, Boehringer, Sanofi, Merieux etc.) Some government match-fund initiatives have emerged (UK Innovation Fund €150m, French Innobio €150 mio, Max Plack) Large European grants through the Innovation Medicines Initiatives (FP7, Eureka etc). Large local grants available in France, Belgium, Italy. Attractive tax credit in France (€1 credit for €3 invested)
  • 20. Not yet out of the woods, but situation is improving Thank You! Florent Gros Managing Director Novartis Venture Funds