0665-L - Implantação do plano diretor da atenção primária à saúde - análise d...bibliotecasaude
Os projetos prioritários que estão sendo implantados em todo o estado pela Secretaria de Estado de Saúde, MG, tem por objetivo, estabelecer "a vida saudável para toda a população mineira, como um benefício direto e claramente perceptível.
0665-L - Implantação do plano diretor da atenção primária à saúde - análise d...bibliotecasaude
Os projetos prioritários que estão sendo implantados em todo o estado pela Secretaria de Estado de Saúde, MG, tem por objetivo, estabelecer "a vida saudável para toda a população mineira, como um benefício direto e claramente perceptível.
OLA APOS VISUALIZAR ENTRE EM CONTATO PARA MAIS INFORMAÇÕES. NÃO PERCA ESSA OPORTUNIDADE.
FACE: http://goo.gl/ezeZj9
FONE: (41)9914-8862
SKYPE: contatoaprovacursos@gmail.com
EMAIL: contatoaprovacursos@gmail.com
DnG SUPER50 adalah Network Marketing yang EXCELLENT, dapat menjadi satu pilihan untuk peternakan duit Anda. Dengan bergabungnya Anda, delapan benefit keunggulan DnG SUPER50 akan diperoleh pada saat Anda memutuskan untuk menjadi bagian dari industri ini, yaitu :
1. Keuntungan Eceran, Min 25%
2. Bonus Rekrut, Rp. 50.000 / Aktivasi
3. Bonus Pasangan, Rp, 40.000 / Pasang
4. Bonus Infinity Rp. 40.000 / Aktivasi
5. Bonus Royalty Infinity
6. Health Maintenance Saving
7. Bonus Reward Health Maintenance Saving
8. Bonus Profit Sharing
Tantangannya sekarang, bagaimana menjadikan rencana pemasaran ini menjadi mesin duit bagi pundi-pundi finansial Anda. Siapa-siapa yang akan direkrut menjadi start up jaringan pemasaran Anda.Ceruk pemasaran produknya dimana saja maupun sisi keunikan produknya apa saja karena produk yang unik akan menjadi sebuah kekuatan untuk berkompetisi dipasar yang dinamis. Berita hebatnya DnG SUPER50 dapat menjawab semua pertanyaan diatas karena produk-produk yang dipasarkan dihasilkan dari pabrik sendiri dibawah naungan DYNAPHARM Group Of Companies yang merupakan sebuah Group Perusahaan Internatinal yang bergerak di bidang Produksi dan Distribusi yang berpusat di Penang, Malaysia. Berdiri sejak tahun 1981, dari pusatnya Penang - Malaysia, kini DYNAPHARM Group terus mengembangkan sayapnya keberbagai negara di 5 benua. Tercatat hingga kini telah 71 Negara yang menggunakan Produk - Produk DYNAPHARM Group.
DYNAPHARM Group memiliki beberapa anak Perusahaan di berbagai belahan dunia, termasuk 4 Pabrik utama milik sendiri, yang memproduksi berbagai macam produk, yaitu :
- Pabrik Dynapharm ( M ) Sdn.Bhd. berdiri sejak tahun 1981 yang memproduksi produk-produk farmasi untuk melayani rumah sakit di Malaysia, Apotik, Klinik, Toko-Toko Obat dan diekspor ke mancanegara.
- China Herbal Medical Works, berdiri tahun 1996 yang memproduksi produk-produk herbal China dengan standard GMP ( Good Manufacturing Practice )
- Dyna Lab. Associate, berdiri sejak tahun 1996 merupakan pusat penelitian, pengembangan dan memproduksi makanan kesehatan alami.
- Dyna Cosmos Care, Sdn.Bhd. berdiri sejak tahun 1998 yang khusus memproduksi produk-produk kosmetik, perawatan kulit, rambut dan toiletries dengan standar GMP
- Ladang Ganoderma terluas di Malaysia, yang menghasilkan produk Ganoderma Lucidum berkualitas untuk pembuatan produk-produk makanan kesehatan yang alami
Visi DnG : Mewujudkan Keluarga Indonesia Yang sehat & Mandiri
Misi DnG : Sebagai Sarana Mewujudkan Keluarga Bahagia
DnG dipimpin oleh pribadi yang mempunyai Integritas, Loyalitas dan Komitmen tinggi, Mr. Oi Hoo Choi selaku CEO DnG International & Mr. Paulus Prawira selaku Managing Director Indonesia.
DnG SUPER50 diperkuat oleh D - SYSTEM yang merupakan sistem penunjang dan training dalam usaha Network Marketing DnG merupakan, ' CARA, JALAN, SARANA BELAJAR, ALAT DUPLIKASI' yang tepat yang telah terbukti hasilnya membuat banyak orang-orang dalam industi ini mengalami lompatan
OLA APOS VISUALIZAR ENTRE EM CONTATO PARA MAIS INFORMAÇÕES. NÃO PERCA ESSA OPORTUNIDADE.
FACE: http://goo.gl/ezeZj9
FONE: (41)9914-8862
SKYPE: contatoaprovacursos@gmail.com
EMAIL: contatoaprovacursos@gmail.com
DnG SUPER50 adalah Network Marketing yang EXCELLENT, dapat menjadi satu pilihan untuk peternakan duit Anda. Dengan bergabungnya Anda, delapan benefit keunggulan DnG SUPER50 akan diperoleh pada saat Anda memutuskan untuk menjadi bagian dari industri ini, yaitu :
1. Keuntungan Eceran, Min 25%
2. Bonus Rekrut, Rp. 50.000 / Aktivasi
3. Bonus Pasangan, Rp, 40.000 / Pasang
4. Bonus Infinity Rp. 40.000 / Aktivasi
5. Bonus Royalty Infinity
6. Health Maintenance Saving
7. Bonus Reward Health Maintenance Saving
8. Bonus Profit Sharing
Tantangannya sekarang, bagaimana menjadikan rencana pemasaran ini menjadi mesin duit bagi pundi-pundi finansial Anda. Siapa-siapa yang akan direkrut menjadi start up jaringan pemasaran Anda.Ceruk pemasaran produknya dimana saja maupun sisi keunikan produknya apa saja karena produk yang unik akan menjadi sebuah kekuatan untuk berkompetisi dipasar yang dinamis. Berita hebatnya DnG SUPER50 dapat menjawab semua pertanyaan diatas karena produk-produk yang dipasarkan dihasilkan dari pabrik sendiri dibawah naungan DYNAPHARM Group Of Companies yang merupakan sebuah Group Perusahaan Internatinal yang bergerak di bidang Produksi dan Distribusi yang berpusat di Penang, Malaysia. Berdiri sejak tahun 1981, dari pusatnya Penang - Malaysia, kini DYNAPHARM Group terus mengembangkan sayapnya keberbagai negara di 5 benua. Tercatat hingga kini telah 71 Negara yang menggunakan Produk - Produk DYNAPHARM Group.
DYNAPHARM Group memiliki beberapa anak Perusahaan di berbagai belahan dunia, termasuk 4 Pabrik utama milik sendiri, yang memproduksi berbagai macam produk, yaitu :
- Pabrik Dynapharm ( M ) Sdn.Bhd. berdiri sejak tahun 1981 yang memproduksi produk-produk farmasi untuk melayani rumah sakit di Malaysia, Apotik, Klinik, Toko-Toko Obat dan diekspor ke mancanegara.
- China Herbal Medical Works, berdiri tahun 1996 yang memproduksi produk-produk herbal China dengan standard GMP ( Good Manufacturing Practice )
- Dyna Lab. Associate, berdiri sejak tahun 1996 merupakan pusat penelitian, pengembangan dan memproduksi makanan kesehatan alami.
- Dyna Cosmos Care, Sdn.Bhd. berdiri sejak tahun 1998 yang khusus memproduksi produk-produk kosmetik, perawatan kulit, rambut dan toiletries dengan standar GMP
- Ladang Ganoderma terluas di Malaysia, yang menghasilkan produk Ganoderma Lucidum berkualitas untuk pembuatan produk-produk makanan kesehatan yang alami
Visi DnG : Mewujudkan Keluarga Indonesia Yang sehat & Mandiri
Misi DnG : Sebagai Sarana Mewujudkan Keluarga Bahagia
DnG dipimpin oleh pribadi yang mempunyai Integritas, Loyalitas dan Komitmen tinggi, Mr. Oi Hoo Choi selaku CEO DnG International & Mr. Paulus Prawira selaku Managing Director Indonesia.
DnG SUPER50 diperkuat oleh D - SYSTEM yang merupakan sistem penunjang dan training dalam usaha Network Marketing DnG merupakan, ' CARA, JALAN, SARANA BELAJAR, ALAT DUPLIKASI' yang tepat yang telah terbukti hasilnya membuat banyak orang-orang dalam industi ini mengalami lompatan
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
